Ключевые слова
Как цитировать
Аннотация
Мультиформная глиобластома (GBM) - наиболее распространенная и инвазивная низкодифференцированная опухоль мозга, характеризующаяся практически 100 %-ным рецидивированием и неблагоприятным прогнозом для пациентов. Цель настоящего обзора - анализ исследований и экспериментальных результатов последних лет (базы данных Scopus, Web of Science, Pubmed), касающихся характерных для глиобластомы соматических мутаций, аберрантной регуляции экспрессии генов сигнальных путей, в т.ч., EGFR, TGFß, а также маркеров прогрессирования GBM. Отдельно обсуждаются молекулярно-генетические субтипы глиобластом и результаты NGS-исследований.Библиографические ссылки
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