EFFECT OF ε-AMINOCAPROIC ACID ON THE GROWTH OF AN INOCULATED ASCITIC AND SOLID EHRLICH TUMOR OF MICE
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Keywords

ε-AMINOCAPROIC ACID
EHRLICH TUMOR
ANTITUMOR ACTIVITY
MICE

How to Cite

Anikin, I., Gubareva, Y., Maydin, M., & Tyndyk, M. (2017). EFFECT OF ε-AMINOCAPROIC ACID ON THE GROWTH OF AN INOCULATED ASCITIC AND SOLID EHRLICH TUMOR OF MICE. Voprosy Onkologii, 63(6), 942–945. https://doi.org/10.37469/0507-3758-2017-63-6-942-945

Abstract

The antitumor activity of the antifibrinolytic drug ε-aminocaproic acid (ACC) in the therapeutic form (5% ACC solution in physiological solution instead of drinking water) was studied in the ascitic and solid Ehrlich tumor. ACC did not affect the growth of ascitic, as well as a solid Ehrlich tumor, when the drug was administered 72 hours after the tumor inoculation. At the same time, when it was administered 7 days after tumor inoculation, the drug had a statistically significant antitumor effect on the tumor nodes formed (8-10 mm in diameter). ACC antitumor effect allows to assume that it influences tumor stroma rather than the parenchyma. This effect is not fully understood and needs further study.
https://doi.org/10.37469/0507-3758-2017-63-6-942-945
PDF (Русский)

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