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Аннотация
«Часовые» гены (ЧГ) являются центральными компонентами генерации циркадных циклов (ЦЦ) в организме, обеспечивающих соответствие его состояния времени суток. Нарушения этого соответствия как со стороны внешних условий (сменная работа, избыточное ночное освещение, смена часовых поясов), так и со стороны изменений в ЦЦ организма, в том числе на уровне ЧГ, являются факторами риска развития опухолей, в первую очередь рака молочной железы (РМЖ). Рассмотрены обзоры и результаты мета-анализа эпидемиологических данных и экспериментальных работ по этой проблеме, опубликованные за последние 5 лет. Наиболее значимым феноменом является существенное повышение риска РМЖ у женщин, имеющих сменный характер работы. Представляется перспективной разработка схем применения мелатонина, позволяющих синхронизировать ЦЦ в опухоли и организме так, чтобы совместить по времени суток максимумы чувствительности опухоли к терапии и резистентности организма к ее возможным побочным эффектам.
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