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Abstract
The aim of the study was to assess the ability of tumor cells of invasive breast carcinoma of a non-specific type (IC NST) which forming various morphological structures to modulate their nearest microenvironment. Material and methods. An analysis was carried out of the data on the expression of the immune system (cytokines, including chemokines, and their receptors, pattern-recognizing molecules and growth factors) genes placed in the GEO database (Gene Expression Omnibus, number GSE80754). Results. The largest number of overexpressing genes that functionally provide parenchymal-stromal relationships is observed in discrete tumor cells. The spectrum of genes that contributed to the polarization in Th2 type of the immuno-inflammatory response was a characteristic for tumor cells building trabecular structures. Cells of tubular structures are characterized by overexpression of the IL15 gene, which attracts NK cells. Alveolar and solid structures do not have a pronounced ability to modulate their microenvironment. Conclusion. Tumor elements of various morphological structures of IC NST are characterized by functional heterogeneity in their ability to influence the type of immuno-inflam-matory reactions in their microenvironment.
References
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