How to Cite
Abstract
The morphological method was used to study the structural characteristics of intracellular and remotely located microvessels during the growth of glioblastoma implanted in the right hemisphere of the rat brain. The studies were carried out for 6 hours to 18 days after the implantation of the tumor. An increase in the proportion (in %) of microvessels with a wide diameter was recorded both in the tumor itself and in remote areas of the tissue of both hemispheres of the brain. A similar trend of changes took place in the dynamics of microvascular areas on sections of the ear of rats that do not have a common blood circulation with the brain. The data obtained make it possible to justify the expediency of further identification of remote tests to assess the parameters of the tumor and the therapeutic measures being developed.
Key words: glioblastoma, morphometry, diameter of microvessels.
References
Яковенко Ю.Г. Глиобластомы: современное состояние проблемы // Медицинский вестник Юга России. 2019;10(4):28–35 [Yakovenko YuG. Glioblastomas: the current state of the problem // Meditsinskii vestnik Yuga Rossii. 2019;10(4):28–35 (In Russ.)].
Brown TJ, Brennan MC, Li M et al. Association of the extent of resection with survival in glioblastoma: a systematic review and meta-analysis // JAMA oncology. 2016;2(11):1460–1469.
Бывальцев В.А., Степанов И.А., Белых Е.Г. и др. Молекулярные аспекты ангиогенеза в глиобластомах головного мозга // Вопросы онкологии. 2017;63(1):19–27 [Byvaltsev VA, Stepanov IA, Belykh EG et al. Molecular aspects of angiogenesis in brain glioblastomas // Voprosy onkologii. 2017;63(1):19–27 (In Russ.)].
Черток В.М., Захарчук Н.В., Черток А.Г. Клеточно-молекулярные механизмы регуляции ангиогенеза в головном мозге // Журнал неврологии и психиатрии им. С.С.Корсакова. Спецвыпуски. 2017;117(8):43–55. doi:10.17116/jnevro20171178243-55 [Chertok VM, Zakharchuk NV, Chertok AG. The cellular and molecular mechanisms of angiogenesis regulation in the brain // S.S. Korsakov Journal of Neurology and Psychiatry // Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova. 2017;117(8):43–55 (In Russ.)]. doi:10.17116/jnevro20171178243-55
Darland DC, Massingham LJ, Smith SR et al. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival // Developmental biology. 2003;264(1):275–88. doi:10.1016/j.ydbio.2003.08.015
Staton CA, Reed MW, Brown NJ. A critical analysis of current in vitro and in vivo angiogenesis assays // International journal of experimental pathology. 2009;90(3):195–221. doi:10.1111/j.1365-2613.2008.00633.x
Lacroix M, Abi-Said D, Fourney DR et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival // Journal of neurosurgery. 2001;95(2):190–8. doi:10.3171/jns.2001.95.2.0190
Gilbert MR, Dignam JJ, Armstrong TS et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma // New England Journal of Medicine. 2014;370(8):699–708. doi:10.1056/NEJMoa1308573
Giakoumettis D, Kritis A, Foroglou N. C6 cell line: the gold standard in glioma research // Hippokratia. 2018;22(3):105–112.
Костеников Н.А., Дубровская В.Ф., Кованько Е.Г. и др. Динамика изменений структурных параметров периваскулярной инвазии глиомы С6 (экспериментальное исследование) // Вопросы онкологии. 2021;67(1):144–149 [Kostenikov NA, Dubrovskaya VF, Kovan’ko EG et al. Glioma C6 perivascular changes of invasion structural parameters variation (research study) // Voprosy onkologii. 2021;67(1):144–149 (In Russ.)].
Петров С.В., Райхлин Н.Т., Ахметов Т.Р. и др. Руководство по иммуногистохимической диагностике опухолей человека. Казань: DESIGNstudio RED, 2012 [Petrov SV, Raikhlin NT, Akhmetov TR et al. Manual on immunohistochemical diagnostics of human tumors. Kazan: DESIGNstudio RED, 2012 (In Russ.)].
Майбородин И.В., Красильников С.Э., Козяков А.Е. и др. Целесообразность изучения опухолевого ангиогенеза, как прогностического фактора развития рака // Новости хирургии. 2015;23(3):339–347 [Maiborodin IV, Krasilnikov SE, Kozjakov AE et al. The Feasibility of Tumor-Related Angiogenesis Study as a Prognostic Factor for Cancer Development // Novosti Khirurgii. 2015;23(3):339–347 (In Russ.)].
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2021