Perminova , A., Kohanenko , N., Khanevich , M., & Zinkovskaya , A. (2023). Differential Diagnosis of Metastatic Lesions in the Pancreas in Patients with Renal Cell Carcinoma and Focal Chronic Pancreatitis: A Clinical Observation. Voprosy Onkologii, 69(2), 328–333. https://doi.org/10.37469/0507-3758-2023-69-2-328-333

Abstract

An observation of a 62-year-old patient with metastatic pancreatic lesion with renal cell carcinoma 15 years after radical nephrectomy on the right is presented. The disease was successfully diagnosed non-surgically: a fine needle puncture biopsy was performed followed by immunohistochemical examination of the drug, thus the diagnosis was verified and focal chronic pancreatitis was excluded. The patient underwent drug antitumor therapy, which she endured well, a partial response was achieved.

Keywords: renal cell carcinoma, renal cell carcinoma, focal pancreatitis, pancreatic carcinoma, pseudocyst of the pancreatic head, immunohistochemical study.

The authors confirm the absence of conflicts of interest.

https://doi.org/10.37469/0507-3758-2023-69-2-328-333

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References

Ballarin R, Spaggiari M, Cautero N, et al. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol. 2011;17(43):4747–4756. doi:10.3748/wjg.v17.i43.4747.

Eidt S, Jergas M, Schmidt R, et al. Metastasis to the pancreas — an indication for pancreatic resection? Langenbecks Arch Surg. 2007;392(5):539–542. doi:10.1007/s00423-007-0148-7.

Hegerova L, Griebeler ML, Reynolds JP, et al. Metastasis to the thyroid gland: report of a large series from the Mayo Clinic. Am J Clin Oncol. 2015;38(4):338–342. doi:10.1097/COC.0b013e31829d1d09.

Zerbi A, Ortolano E, Balzano G, et al. Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol. 2008;15(4):1161–1168. doi:10.1245/s10434-007-9782-0.

Chi TY, Sang XT, Mao YL, et al. [Diagnosis and treatment of pancreatic metastasis from renal cell carcinoma]. Zhonghua Zhong Liu Za Zhi. 2008;30(10):793–796.

Shaun Kian Hong C, Khoon Leong C. Metastatic renal cell carcinoma to the pancreas: a review. Arch Pathol Lab Med. 2016;140(6):598–602. doi:10.5858/arpa.2015-0135-RS.

Hoshino Y, Shinozaki H, Kimura Y, et al. Pancreatic metastases from renal cell carcinoma: a case report and literature review of the clinical and radiological characteristics. World J SurgOncol. 2013;11:289. doi:10.1186/1477-7819-11-289.

Wente MN, Kleeff J, Esposito I, et al. Renal cell metastasis into the pancreas: a single-center experience and overview of the literature. Pancreas. 2005;30(3):218–222. doi:10.1097/01.mpa.0000153337.58105.47.

Sellner F, Tykalsky N, De Santis M, et al. Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann SurgOncol. 2006;13(1): 75–85. doi:10.1245/ASO.2006.03.064.

Wu C, Zhou Z, Ye X, et al. Synchronous renal cell carcinoma metastasis to the contralateral adrenal gland and pancreas: A case report with 7-year follow-up subsequent to surgical therapy. Oncol Lett. 2016;11(6):4144–4146. doi:10.3892/ol.2016.4510.

Al Abdrabalnabi AA, AlQattan AS, Algarni S, et al. Metastatic renal cell carcinoma to the pancreas, thyroid, & subcutaneous tissue 13 years after Radical nephrectomy: A case report. Int J Surg Case Rep. 2019;60:183–185. doi:10.1016/j.ijscr.2019.05.031.

Gajendra S, Sachdev R, Mohapatra I, et al. Metastatic renal cell carcinoma: an unusual cause of bleeding pancreatic mass. J Clin Diagn Res. 2015;9(9):ED15–17. doi:10.7860/JCDR/2015/14350.6519.

Ballarin R, Spaggiari M, Cautero N, et al. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol. 2011;17(43):4747–4756. doi:10.3748/wjg.v17.i43.4747.

Vieira de Ribeiro AJ, Sandim V, Ornellas AA, et al. Differencial proteome of clear-cell renal cell carcinoma (ccRCC) tissues. Int Braz J Urol. 2013;39(1):83–94. doi:10.1590/S1677-5538.IBJU.2013.01.11.

Fikatas P, Klein F, Andreou A. Long-term survival after surgical treatment of renal cell carcinoma metastasis within the pancreas. Anticancer Res. 2016;36(8):4273–4278.

Yoshinaga S, Suzuki H, Oda I, et al. Role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for diagnosis of solid pancreatic masses. Dig Endosc. 2011;23(Suppl. 1):29-33. doi:10.1111/j.1443-1661.2011.01112.x.

Wolf S, Obolonczyk L, Sworczak K, et al. Renal cell carcinoma metastases to the pancreas and the thyroid gland 19 years after the primary tumour. Prz Gastroenterol. 2015;10(3):185–189. doi:10.5114/pg.2015.49000.

Shi HY, Zhao XS, Miao F. Metastases to the pancreas: computed tomography imaging spectrum and clinical features: a retrospective study of 18 patients with 36 metastases. Medicine (Baltimore). 2015;94(23):e913. doi:10.1097/MD.0000000000000913.

Vincenzi M, Pasquotti G, Polverosi R, et al. Imaging of pancreatic metastases from renal cell carcinoma. Cancer Imaging. 2014;14(1):5. doi:10.1186/1470-7330-14-5.

Ghavamian R, Klein KA, Stephens DH, et al. Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin Proc. 2000;75(6):581–585. doi:10.4065/75.6.581.

Palmowski M, Hacke N, Satzl S, et al. Metastasis to the pancreas: characterization by morphology and contrast enhancement features on CT and MRI. Pancreatology. 2008;8(2):199–203. doi:10.1159/000128556.

Yun HS, Min YW, Lee MJ, et al. Clinicoradiologic characteristics and outcomes of metastatic cancer to the pancreas and double primary pancreatic cancer. Clin Res Hepatol Gastroenterol. 2013;37(2):182–188. doi:10.1016/j.clinre.2012.05.013.

Pitman MB, Deshpande V. Endoscopic ultrasound-guided fine needle aspiration cytology of the pancreas: a morphological and multimodal approach to the diagnosis of solid and cystic mass lesions. Cytopathology. 2007;18(6):331–347. doi:10.1111/j.1365-2303.2007.00457.x.

El Hajj II, LeBlanc JK, Sherman S, et al. Endoscopic ultrasound-guided biopsy of pancreatic metastases: a large single-center experience. Pancreas. 2013;42(3):524–530. doi:10.1097/MPA.0b013e31826b3acf.

Hoshino Y, Shinozaki H, Kimura Y, et al. Pancreatic metastases from renal cell carcinoma: A case report and literature review of the clinical and radiological characteristics. World J Surg Oncol. 2013;11:289. doi:10.1186/1477-7819-11-289.

Ballarin R, Spaggiari M, Cautero N, et al. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol. 2011;17(43):47474756. doi:10.3748/wjg.v17.i43.4747.

Strobel O, Hackert T, Hartwig W, et al. Survival data justifies resection for pancreatic metastases. Ann Surg Oncol. 2009;16(12):3340–3349. doi:10.1245/s10434-009-0682-3.

Singer EA, Gupta GN, Srinivasan R. Update on targeted therapies for clear cell renal cell carcinoma. Curr Opin Oncol. 2011;23(3):283–289. doi:10.1097/CCO.0b013e32834479c0.

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