Keywords
How to Cite
Abstract
Introduction. Oral cancer (RPR), currently occupies a leading position in the structure of malignant neoplasms of the head and neck.
Observation. Two clinical cases of pregnancy-associated RPR are presented, and the aggressive course of the disease, which led to fatal outcomes in both cases, is demonstrated.
Conclusions. The presence of pregnancy significantly worsens the course and prognosis of RPR in patients. It was revealed that this oncopathology in pregnant women is accompanied by resistance to standard methods and treatment regimens. This group of patients needs to develop new methodological approaches in antitumor treatment based on an in-depth analysis of the molecular genetic characteristics of the tumor, hormonal background in general and its effect on the tumor process during pregnancy. Such a personalized approach will improve the results of treatment of young patients during pregnancy.
References
Под ред. A.Д. Кaпринa, В.В. Стaринского, A.О. Шaхзaдовой Состояние онкологической помощи нaселению России в 2021 году. М.: МНИОИ им. П.A. Герценa − филиaл ФГБУ «НМИЦ рaдиологии» Минздрaвa России. 2022:239 [Kaprin AD, Starinsky VV, Shakhzadova AO, eds. The state of oncological care to the population of Russia in 2021. Moscow: P.A. Herzen Moscow State Medical Research Institute - branch of the Federal State Budgetary Institution «NMHC of Radiology» of the Ministry of Health of Russia. 2022:239 (In Russ.)].
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human Papillomaviruses. Lyon (FR): International Agency for Research on Cancer; 2007.
Tommasino M. The human papillomavirus family and its role in carcinogenesis. Semin Cancer Biol. 2014;26:13-21. https://doi.org/10.1016/j.semcancer.2013.11.002.
zur Hausen H. Papillomavirus infections--a major cause of human cancers. In Infections Causing Human Cancer. Weinheim, Germany: Wiley-VCH Verlag; 2006:145-243.
Dalianis T. Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review). Int J Oncol. 2014;44(6):1799-805. https://doi.org/10.3892/ijo.2014.2355.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Biological agents. IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt B):1-441.
Чернышова А.Л., Коломиец Л.А., Черняков А.А., и др. Особенности течения меланомы на фоне беременности. Вопросы онкологии. 2023;69(2):322-7 [Chernyshova AL, Kolomiets LA, Chernyakov AA, et al. Features of the course of melanoma during pregnancy. Voprosy Onkologii. 2023;69(2):322-7 (In Russ.)]. https://doi.org/10.37469/0507-3758-2023-69-2-322-327.
Pentheroudakis G, Pavlidis N. Cancer and pregnancy: poena magna, not anymore. Eur J Cancer. 2006;42(2):126-40. https://doi.org/10.1016/j.ejca.2005.10.014.
Le Guevelou J, Lebars S, Kammerer E, et al. Head and neck cancer during pregnancy. Head Neck. 2019;41(10):3719-3732. https://doi.org/10.1002/hed.25877.
Javitt MC. Cancer in pregnancy: overview and epidemiology. Abdom Radiol (NY). 2023;48(5):1559-1563. https://doi.org/10.1007/s00261-022-03633-y.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2023