Vol. 63 No. 2 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 2 (2017)

FEATURES OF RECURRENCE OF BCRA-POSITIVE OVARIAN CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-2-298-303

Published 01.02.2017

Tatyana Gorodnova⁺⁻
N. Matveeva⁺⁻
Yevgeniy Imyanitov⁺⁻
Igor Berlev⁺⁻
Adiliya Urmancheeva⁺⁻
Nikolay Mikaya⁺⁻
Anna Sidoruk⁺⁻
Yekaterina Nekrasova⁺⁻
Irina Meshkova⁺⁻
Yelena Ulrikh⁺⁻
Katran Guseynov⁺⁻
Khristina Kotiv⁺⁻
Yekaterina Kuligina⁺⁻
Anna Sokolenko⁺⁻
Yu. Trifanov⁺⁻

Tatyana Gorodnova

N.N. Petrov Research Institute of Oncology

N. Matveeva

N.N. Petrov Research Institute of Oncology

Yevgeniy Imyanitov

N.N. Petrov Research Institute of Oncology, North-Western State Medical University named after I.I. Mechnikov

Igor Berlev

N.N. Petrov Research Institute of Oncology, North-Western State Medical University named after I.I. Mechnikov

Adiliya Urmancheeva

N.N. Petrov Research Institute of Oncology, North-Western State Medical University named after I.I. Mechnikov

Nikolay Mikaya

N.N. Petrov Research Institute of Oncology

Anna Sidoruk

N.N. Petrov Research Institute of Oncology, North-Western State Medical University named after I.I. Mechnikov

Yekaterina Nekrasova

N.N. Petrov Research Institute of Oncology

Irina Meshkova

N.N. Petrov Research Institute of Oncology

Yelena Ulrikh

N.N. Petrov Research Institute of Oncology, North-Western State Medical University named after I.I. Mechnikov

Katran Guseynov

N.N. Petrov Research Institute of Oncology

Khristina Kotiv

N.N. Petrov Research Institute of Oncology

Yekaterina Kuligina

N.N. Petrov Research Institute of Oncology

Anna Sokolenko

N.N. Petrov Research Institute of Oncology

Yu. Trifanov

N.N. Petrov Research Institute of Oncology

PDF (Русский)

Keywords

OVARIAN CANCER
ГЕНЫ BRCA1/2
BRCA1 GENES
RECURRENCE OF THE DISEASE
CHEMOSENSITIVITY

How to Cite

Gorodnova, T., Matveeva, N., Imyanitov, Y., Berlev, I., Urmancheeva, A., Mikaya, N., Sidoruk, A., Nekrasova, Y., Meshkova, I., Ulrikh, Y., Guseynov, K., Kotiv, K., Kuligina, Y., Sokolenko, A., & Trifanov, Y. (2017). FEATURES OF RECURRENCE OF BCRA-POSITIVE OVARIAN CANCER. Voprosy Onkologii, 63(2), 298–303. https://doi.org/10.37469/0507-3758-2017-63-2-298-303

Abstract

The study included 160 patients with advanced ovarian cancer (OC) who underwent combined treatment from January 2000 to January 2013 at the N.N. Petrov Research Institute of Oncology. Compared to non-mutated patients, BRCA-positive patients were characterized by a longer platinum-free interval (BFI) (14 months [95% CI 9.6-36.4 months] versus 8 months [95% Ci 4.8-12.4 months]; P = 0.006), with the largest median of the BFI were established using the CAP scheme - 33.5 months versus 12 months using the TCbP scheme. Half of patients with a mutation in the BRCA1 gene (20/40 (50%)) had an isolated recurrence in the pelvic area versus 35/120 (29.2%) of patients without mutations (p = 0.00001). The progression of distant foci in the first recurrence of the disease in patients with mutations was significantly lower (15/40 (37.5%) versus 84/120 (70%), p = 0.00001). In addition 85% of recurrences in BRCA-positive patients were platinum-sensitive. Only the age of patients with advanced OC was an independent prognostic factor of BFI since the start of treatment (p = 0.00001).

https://doi.org/10.37469/0507-3758-2017-63-2-298-303

PDF (Русский)

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