Vol. 63 No. 5 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 5 (2017)

THE PATH TO PERSONALIZED TREATMENT OF BREAST CANCER PATIENTS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-5-719-723

Published 01.05.2017

Oleg Kit⁺⁻
Yuliana Shatova⁺⁻
Yelena Frantsiyants⁺⁻
Inna Novikova⁺⁻
Yelena Zlatnik⁺⁻
Larisa Vashchenko⁺⁻
Lyubov Vladimirova⁺⁻
Yelena Dzhenkova⁺⁻
Nadezhda Nikolaeva⁺⁻

Oleg Kit

Rostov Research Institute of Oncology

Yuliana Shatova

Rostov Research Institute of Oncology

Yelena Frantsiyants

Rostov Research Institute of Oncology

Inna Novikova

Rostov Research Institute of Oncology

Yelena Zlatnik

Rostov Research Institute of Oncology

Larisa Vashchenko

Rostov Research Institute of Oncology

Lyubov Vladimirova

Rostov Research Institute of Oncology

Yelena Dzhenkova

Rostov Research Institute of Oncology

Nadezhda Nikolaeva

Rostov Research Institute of Oncology

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Keywords

BREAST CANCER
PERSONALIZED TREATMENT

How to Cite

Kit, O., Shatova, Y., Frantsiyants, Y., Novikova, I., Zlatnik, Y., Vashchenko, L., Vladimirova, L., Dzhenkova, Y., & Nikolaeva, N. (2017). THE PATH TO PERSONALIZED TREATMENT OF BREAST CANCER PATIENTS. Voprosy Onkologii, 63(5), 719–723. https://doi.org/10.37469/0507-3758-2017-63-5-719-723

Abstract

Risk factors, p53, bcl-2, Topo2α, E-cadgerin, androgen receptor's expression, estrodiol, estron, testosterone, progesterone, prolactin, estrogen methabolitis, sex-steroid connecting globulin, growth factors: VEGF, EGF, TGFß1, IGF1, IGF2, plasmin, plasminogen, u-PA, t-PA, PAI-1 levels in the tumor and perifocal tissue, population and subpopulation structure of the lymphocytes in peripheral blood, tumor and perifocal tissue, ploidy and cell cycle estimating among the 850 patients with different biologic breast cancer subtypes were tested. «Statistica 7.0» and MedCalc (version 9.3.5.0) were used for the statistical analysis. The results showed that it was impossible to analyze breast cancer only as a biological subtype according to the typical IGC. It was needed to use and other external and internal factors, determine biologic tumor behavior in complex with menstrual state of a woman. Only such way allowed developing the preventive services according tumor biological characteristics and patient's individual parameters and going to really personalized treatment and improving its results.

https://doi.org/10.37469/0507-3758-2017-63-5-719-723

##article.numberofdownloads## 34

##article.numberofviews## 123

PDF (Русский)

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