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Abstract
Among the factors determining the relapse/persistence of papillary thyroid cancer in children and adolescents the most important are the age of the patient (p= 0.003), the presence of concomitant background pathology (p <0.001), minimal extrathyroid spread (p=0.048), the presence of metastases in the lateral group (level II-IV) of the lymph nodes of the neck (p <0.001), expressed intratumor fibrosis (p = 0.016), microscopic invasion of lymphatic (p<0.001) and blood (p=0.014) vessels. Of the additional features determining the risk of recurrence of the disease metastatic index (MI) is of the importance, which refers to the ratio of the number of lymph nodes with metastases to the total number of detected lymph nodes minus the number of lymph nodes with metastases +1 as well as the qualitative characteristics of metastases in the lymph nodes (micro-, macro- and metastases with extranodal growth). The results of a comprehensive study of tumor and its metastases in the central lymph nodes of the neck (level VI) are recommended to be taken into account for the personalization of treatment regimens of patients of this age group.References
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