Vol. 64 No. 6 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 6 (2018)

BIOPHISICAL MODEL OF ISOLATED LUNG CHEMOPERFUSION AND PHARMACOKINETICS OF CISPLATIN

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-6-782-787

Published 01.06.2018

Aleksandr Mikhnin⁺⁻
Yevgeniy Levchenko⁺⁻
Oleg Mamontov⁺⁻
P. Kalinin⁺⁻
K. Senchik⁺⁻
ChZhAN VEN⁺⁻
VAN TIN⁺⁻
A. Myasnikov⁺⁻

Aleksandr Mikhnin

N.N. Petrov National Medical Cancer Research Centre of Oncology, I.I. Mechnikov North-West State Medical University

Yevgeniy Levchenko

N.N. Petrov National Medical Cancer Research Centre of Oncology, I.I. Mechnikov North-West State Medical University

Oleg Mamontov

N.N. Petrov National Medical Cancer Research Centre of Oncology

P. Kalinin

N.N. Petrov National Medical Cancer Research Centre of Oncology

K. Senchik

N.N. Petrov National Medical Cancer Research Centre of Oncology

ChZhAN VEN

N.N. Petrov National Medical Cancer Research Centre of Oncology

VAN TIN

N.N. Petrov National Medical Cancer Research Centre of Oncology

A. Myasnikov

Saint-Petersburg State University

PDF (Русский)

Keywords

ISOLATED LUNG CHEMOPERFUSION
BIOPHYSICAL MODEL
CISPLATIN
CT-VOLUMETRY OF THE LUNG
DIFFUSION MODEL OF PERFUSION

How to Cite

Mikhnin, A., Levchenko, Y., Mamontov, O., Kalinin, P., Senchik, K., VEN, C., TIN, V., & Myasnikov, A. (2018). BIOPHISICAL MODEL OF ISOLATED LUNG CHEMOPERFUSION AND PHARMACOKINETICS OF CISPLATIN. Voprosy Onkologii, 64(6), 782–787. https://doi.org/10.37469/0507-3758-2018-64-6-782-787

Abstract

The individualization of cytostatic agent dose is an actual problem in isolated lung chemoperfusion (ILP). Hitherto it has been carried out according to anthropometric data, in particular, the surface area of the body. A biophysical model of ILP based on diffusion cisplatin transfer in the lung is proposed. The model indicates to get the individual drug dose according to physical lung volume, which can be measured by CT-volumetry. Cisplatin pharmacokinetics and model compliance with actual data are considered on the material of 28 ILP. Estimates of lung interstitial and vascular space volumes and diffusion characteristic of capillary membrane are obtained.

https://doi.org/10.37469/0507-3758-2018-64-6-782-787

PDF (Русский)

References

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