Vol. 65 No. 2 (2019), ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

Vol. 65 No. 2 (2019)

METHODS OF CREATION OF ORTHOTOPIC MODELS OF HUMAN COLON CANCER IN IMMUNODEFICIENT ANIMALS

ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-2-303-307

Published 01.02.2019

Oleg Kit⁺⁻
Anna Goncharova⁺⁻
Yekaterina Lukbanova⁺⁻

Oleg Kit

Rostov Research Institute of Oncology

Anna Goncharova

Rostov Research Institute of Oncology

Yekaterina Lukbanova

Rostov Research Institute of Oncology

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Keywords

XENOGRAFT
COLON CANCER
ORTHOTOPIC TUMOR MODELS
REVIEW

How to Cite

Kit, O., Goncharova, A., & Lukbanova, Y. (2019). METHODS OF CREATION OF ORTHOTOPIC MODELS OF HUMAN COLON CANCER IN IMMUNODEFICIENT ANIMALS. Voprosy Onkologii, 65(2), 303–307. https://doi.org/10.37469/0507-3758-2019-65-2-303-307

Abstract

Colon cancer has long been considered an important and actual problem in oncology. Studies performed on animal models are significant for understanding molecular patterns of the disease development and developing new antitumor drugs. Such models are the most adequate tool for evaluating the cancer treatment strategy and a resource with enormous potential for studying tumorigenesis mechanisms. In this review, we analyzed the recent data on methods of modeling the process of development of malignant tumors in the human intestine on immuno-deficient animals and considered advantages and disadvantages of different model variants.

https://doi.org/10.37469/0507-3758-2019-65-2-303-307

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##article.numberofviews## 144

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References

Идиятуллина Э.Т., Павлов В.Н., Yuan Y, Cai B. Современные представления о лечении колоректального рака с метастазами // Медицинский вестник Башкортостана. - 2017. - Т. 12. - № 5. - С. 124-127

Кит О.И. Проблема колоректального рака в начале XXI века: достижения и перспективы // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - 2013. - Т 23. - №. 3. - С. 65-71

Федоров В.Э., Поделякин К.А. Эпидемиологические аспекты колоректального рака // Медицинский альманах. - 2017. - №. 4. - С. 145-148

Трещалина Е.М. Иммунодефицитные мыши Balb/c Nude и моделирование различных вариантов опухолевого роста для доклинических исследований // Российский биотерапевтический журнал. - 2017. - Т 16. - № 3. - С. 6-13

Холоденко Р.В., Доронин И.И., Холоденко И.В. Опухолевые модели в изучении онкологических заболеваний // Иммунология. - 2013. - Т. 34. - №. 5. - С. 282286

Хромова Н.В., Копнин П.Б., Копнин Б.П. Стимуляция гемангиогенеза, лимфангиогенеза и васкулогенной мимикрии при различных нарушениях функции опухолевого супрессора р53 в ксенографтах рака ободочной кишки // Онкологическая колопроктология. - 2011. -№. 2. - С. 37-43

Scholz C.C., Berger D.P., Winterhalter B.R. et al. Correlation of drug response in patients and in the clonogenic assay with solid human tumor xenografts. Eur. J. Cancer. 1990; 26: 901-905. (90)90196-Z. DOI: 10.1016/0277-5379

Bhullar J.S., Makarawo T., Subhas G. et al. A true orthotopic gastric cancer murine model using electrocoagulation. J Am Coll Surg. 2013; 217: 64-70. DOI: 10.1016/j.jamcollsurg.2013.01.062

Johnson J.I., Decker S., Zaharevitz D. et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer. 2001; 84: 1424-1431. DOI: 10.1054/bjoc.2001.1796

Miller S., Senior P.V., Prakash M.V. et al. Leukocyte populations and IL-6 in the tumor microenvironment of an orthotopic colorectal cancer model Acta Biochim Biophys Sin (Shanghai). 2016; 48(4): 334-341. gmw002. DOI: 10.1093/abbs/

Donelli M.G., Rosso R., Garattini S. Selective chemotherapy in relation to the site of tumor transplantation. Int. J. Cancer. 1967; 2: 421-424. DOI: 10.1002/ijc.2910020503

Wilmanns C., Fan D., O’Brian C. et al. Modulation of doxorubicin sensitivity and level of P-glycoprotein expression in human colon carcinoma cells by ectopic and orthotopic environments in nude mice. Int. J. Oncol. 1993; 3: 413-422. DOI: 10.3892/ijo.3.3.413

Porru M., Artuso S., Salvati E. et al. Targeting G-Quadru-plex DNA structures by EMICORON has a strong antitumor efficacy against advanced models of human colon cancer. Mol Cancer Ther. 2015; 14(11): 2541-2551. DOI: 10.1158/1535-7163

Evans J.P., Winiarski B.K., Sutton P.A. et al. The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer Oncotarget. 2018; 9(43): 27104-27116. DOI: 10.18632/oncotarget.25497

Hite N., Klinger A., Hellmers L. et al. An optimal orthotopic mouse model for human colorectal cancer primary tumor growth and spontaneous metastasis. dis colon rectum. 2018; 61(6): 698-705. DOI: 10.1097/DCR.0000000000001096

Liao H.-W., Hung M.-C. Intracaecal orthotopic colorectal cancer xenograft mouse model. Bio Protoc. 2017; 7(11): DOI: 10.21769/BioProtoc.2311

Talmadge J.E., Singh R.K., Fidler I.J., Raz A. Murine models to evaluate novel and conventional therapeutic strategies for cancer. The American Journal of Pathology. 2007; 170(3): 793-804. DOI: 10.2353/ajpath.2007.060929

Costa M.J., Kudaravalli J., Liu W.H. et al. A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics. PLoS One. 2018; 13(3):e0194688. DOI: 10.1371/journal.pone.0194688

Palucka A.K., Coussens L.M. The basis of oncoimmu-nology. Cell. 2016; 164:1233-1247. 10.1016/j. Cell.2016.01.049. DOI: 10.1016/j.cell.2016.01.049

Fesnak A.D., June C.H., Levine B.L. Engineered T-cells: the promise and challenges of cancer immunotherapy. Nat Rev Cancer. 2016; 16:566-581. DOI: 10.1038/nrc.2016.97

Zhao X., Li L., Starr T.K., Subramanian S. Tumor location impacts immune response in mouse models of colon cancer. Oncotarget, 2017; 8(33): 54775-54787. DOI: 10.18632/oncotarget.18423

Wege A.K. Humanized mouse models for the preclinical assessment of cancer immunotherapy. BioDrugs. 2018; 32(3): 245-266. DOI: 10.1007/s40259-018-0275-4

Mukohyama J., Shimono X., Yamashita K., et al. Effect of xenotransplantation site on MicroRNA expression of human colon cancer stem cells. Anticancer Res. 2016; 36(7):3679-86.

Lal N., White B.S., Goussous G. et al. Are Independently associated with reduced immune infiltration and reactivity in colorectal cancer. Clin Cancer Res. 2018; 24(1): 224-233. DOI: 10.1158/1078-0432.CCR-17-1090

Metildi C.A., Kaushal S., Snyder C.S. et al. Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model J Surg Res. 2013; 179(1): 87-93. DOI: 10.1016/j.jss.2012.08.052

Priolli D.G., Abrantes A.M., Neves S. et al. A novel model of distal colon cancer in athymic mice.Acta Cir Bras. 2012; 27: 355-360. DOI: 10.1590/S0102-86502012000600001

Wang J., Chen C., Wang S. et al. Bufalin Inhibits HCT116 colon cancer cells and its orthotopic xenograft tumor in mice model through genes related to apoptotic and PTEN/AKT pathways. Gastroenterol. Res. Pract. 2015; 457193. DOI: 10.1155/2015/457193

Bhullar J.S., Subhas G., Silberberg B. et al. A novel nonoperative orthotopic colorectal cancer murine model using electrocoagulation. J Am Coll Surg 2011; 213: 54-60; discussion 60-61. DOI: 10.1016/j.jamcollsurg.2011.02.022

Park J.Y., Murakami T., Lee J.Y. et al. Fluorescent-antibody targeting of insulin-like growth factor-1 receptor visualizes metastatic human colon cancer in orthotopic mouse models. PLoS One. 2016; 11(1): DOI: 10.1371/journal.pone.0146504

Mittal V.K., Bhullar J.S., Jayant K. Animal models of human colorectal cancer: Current status, uses and limitations. World Journal Gastroenterology. 2015; 21(41): 1185411861. DOI: 10.3748/wjg.v21.i41.11854

Fu X.Y., Besterman J.M., Monosov A., Hoffman R.M. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci USA. 1991; 88: 93459349. DOI: 10.1073/pnas.89.12.5645

Metildi C.A., Kaushal S., Luiken G.A. et al. Fluorescently-la-beled chimeric anti-CEA antibody improves detection and resection of human colon cancer in an orthotopic nude mouse model. J Surg Oncol. 2014; 109(5): 451-458. DOI: 10.1002/jso.23507

Fumagallia A., Drosta J., Suijkerbuijka S.J. et al. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids Proc Natl Acad Sci U S A. 2017;114(12): E2357-E2364. DOI: 10.1073/pnas.1701219114

Matano M., Date S., Shimokawa M. et al. Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med. 2015; 21(3):2562-62. DOI: 10.1038/nm.3802

Zigmond E., Halpern Z., Elinav E. et al. Utilization of murine colonoscopy for orthotopic implantation of colorectal cancer. PLoS One 2011; 6: e28858. DOI: 10.1371/journal.pone.0028858

Takahashi T., Morotomi M., Nomoto K. A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells. Cancer Sci 2004; 95: 514-519 DOI: 10.1371/journal.pone.0079453

Kishimoto H., Momiyama M., Aki R., et al. Development of a clinicallyprecise mouse model of rectal cancer. PLoS One 2013; 8: e79453 DOI: 10.1371/journal.pone.0079453

Андронова Н.В., Ситдикова С.М., Морозова Л.Ф. и др. Моделирование ортотопического роста рака почки человека с перевиваемым штаммом РПоч1 на иммунодефицитных мышах // Российский биотерапевтический журнал. - 2017. - Т. 16. - №. 1. - С 51-60.

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