СОВРЕМЕННАЯ ТЕРАПИЯ РЕЦИДИВОВ И РЕЗИСТЕНТНЫХ ФОРМ ЛИМФОМЫ ХОДЖКИНА
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Ключевые слова

ЛИМФОМА ХОДЖКИНА
ТЕРАПИЯ РЕЦИДИВОВ И РЕЗИСТЕНТНЫХ ФОРМ

Аннотация

Несмотря на успехи химиотерапии первой линии классической лимфомы Ходжкина, у части пациентов развивается рецидив или рефрактерное течение заболевания. стандартом лечения рецидива в течение последних лет по-прежнему является терапия «спасения» с последующей высокодозной химиотерапией и аутологичной трансплантацией гемопоэтических стволовых клеток крови. Брентуксимаб ведотин, совершивший настоящую революцию в лечении пациентов с лимфомой Ходжкина, показал свою высокую эффективность не только в лечении рецидива, но и в качестве поддерживающей опции после аутологичной трансплантации в группе пациентов высокого риска. В эру новых агентов для пациентов с рецидивом после аутологичной трансплантации костного мозга существует несколько терапевтических подходов в виде моно- и полихимиотерапии, конъюгата моноклонального антитела брентуксимаб, иммунотерапии «check-point» ингибиторами ниволумаб и пембролизумаб. Аллогенная трансплантация может быть рассмотрена у молодых пациентов с химиочувствительной опухолью при наличии донора костного мозга. Выбор терапевтического подхода должен всегда осуществляться с учетом возраста, сопутствующих заболеваний, предшествующего лечения, предпочтений пациента и лекарственных возможностей.
https://doi.org/10.37469/0507-3758-2018-64-3-419-428
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