Vol. 66 No. 3 (2020), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 66 No. 3 (2020)

CHANGES IN THE IMMUNE STATUS OF PATIENTS WITH METASTATIC SOLID TUMORS DURING STEREOTACTIC RADIATION THERAPY

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2020-66-3-277-282

Published 01.03.2020

Anton Zozulya⁺⁻
Sergey Novikov⁺⁻
Irina Baldueva⁺⁻
D. Girdyuk⁺⁻
Natalya Yemelyanova⁺⁻
Yelena Tyuryaeva⁺⁻
E. Fedosova⁺⁻
F. Antipov⁺⁻
A. Navoloka⁺⁻
Sergey Kanaev⁺⁻
Aleksey Belyaev⁺⁻

Anton Zozulya

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Sergey Novikov

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Irina Baldueva

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

D. Girdyuk

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Natalya Yemelyanova

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Yelena Tyuryaeva

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

E. Fedosova

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

F. Antipov

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

A. Navoloka

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Sergey Kanaev

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia

Aleksey Belyaev

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia, I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

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Keywords

METASTATIC TUMOR PROCESS
STEREOTACTIC BODY RADIATION THERAPY (SBRT)
IMMUNOTHERAPY
IMMUNE STATUS
ACTIVATION OF T-LYMPHOCYTES

How to Cite

Zozulya, A., Novikov, S., Baldueva, I., Girdyuk, D., Yemelyanova, N., Tyuryaeva, Y., Fedosova, E., Antipov, F., Navoloka, A., Kanaev, S., & Belyaev, A. (2020). CHANGES IN THE IMMUNE STATUS OF PATIENTS WITH METASTATIC SOLID TUMORS DURING STEREOTACTIC RADIATION THERAPY. Voprosy Onkologii, 66(3), 277–282. https://doi.org/10.37469/0507-3758-2020-66-3-277-282

Abstract

Purpose. To evaluate immunological status in patients with metastatic forms of solid tumors before and at different intervals after stereotactic body radiation therapy (SBRT) of metastatic lesions. Materials and methods. A quantitative assessment and analysis of blood immunological parameters was conducted before irradiation, after 3-4 weeks and 6-8 weeks after SBRT in patients with malignant tumors with oligometastases in the liver and lungs. All peripheral blood samples were analyzed by flow cytometry. Statistical analysis was performed using Friedman and Nemenyi criteria. Results. 3-4 weeks after the end of SBRT, we observed statistically significant increase of T-lymphocytes (CD3+CD19-); T-helpers (CD3+CD4+); activated T-helpers (CD3+CD4+HLA-DR+); activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) and decrease of B-lymphocytes (CD3-CD19+). Subsequently, after 6-8 weeks after the end of irradiation we detected decrease of T-lymphocytes (CD3+CD19-) and continuing increase in activated T-helpers (CD3+CD4+HLA-DR+) and activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+). Conclusion. Thus, revealed dynamics of immunological parameters indicates the induction of the T-cell link of antitumor immunity against decreasing of indicators of humoral immunity.

https://doi.org/10.37469/0507-3758-2020-66-3-277-282

##article.numberofdownloads## 33

##article.numberofviews## 295

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