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Abstract
Liposarcomas are malignant tumors of mesenchymal origin and are one of the most common human soft tissue sarcomas. Primary mediastinal liposarcomas, first mentioned in 1939, account for less than 1% of all mediastinal tumors, whereas primary mediastinal liposarcomas account for approximately 1% of liposarcomas of all localizations. Mediastinal liposarcomas are a heterogeneous group of tumors with different morphology, which are often characterized by aggressive disease course leading to patient’s death. Differentiated liposarcoma, the most common subtype of primary liposarcomas of the anterior mediastinum, is a low-grade tumor characterized by proliferation of mature adipose tissue mixed with scattered atypical lipoblastic cells. In the current article, we present a clinical observation of a patient with giant lymphosarcoma of the anterior mediastinum who has undergone viral pneumonia. The long-term existence of the tumor before treatment was the peculiarity of the present case. In our opinion, this observation is of interest for the diagnosing and determination of treatment approach in patients with orphan mediastinal tumors.
References
Suster DI, Suster S. Liposarcomas of the mediastinum // Mediastinum 2020;4:27. doi:10.21037/med-20-42
Fu Z, Yang K, Yang X et al. Primary intrathoracic liposarcoma: a clinical analysis of 31 cases // Cancer Commun (Lond). 2019;39(1):15. doi:10.1186/s40880-019-0358-8
Kozonis M.C, Wiggers R.F, Golden H.M. Primary liposarcoma of the mediastinum // Ann Intern Med. 1951;35(3):703–10. doi:10.7326/0003-4819-35-3-703
Лазутин Ю.Н., Карташов С.З., Зинькович С.А. и др. Современные подходы к лечению больных с опухолями средостения // Известия самарского научного центра Российской академии наук. 2009;11(5–2):468–471 [Lazutin YuN, Kartashov SZ, Zinkovich SA et al. Modern approaches to treatment of patients with tumors of mediastinum // Proceedings of the Samara Scientific Center of the Russian Academy of Sciences. 2009;11(5–2):468–471 (In Russ.)].
WHO Classification of Tumours. Soft Tissue and Bone Tumours. 5th Edition. 2020.
Hahn HP, Fletcher CD. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases // Am J Surg Pathol. 2007;31(12):1868–74. doi:10.1097/PAS.0b013e318093f925
Anand Rajan KD, Subbarao KC, Agarwala S, Gupta SD. Mediastinal liposarcoma of mixed type in childhood: a report of a case with unusual histologic features // Indian J Pathol Microbiol. 2010;53(3):525–8. doi:10.4103/0377-4929.68297
Munden RF, Nesbitt JC, Kemp BL et al. Primary liposarcoma of the mediastinum // AJR Am J Roentgenol. 2000;175(5):1340. doi:10.2214/ajr.175.5.1751340
Inaba H, Furuta Y, Usuda R et al. Liposarcoma originating in the neck and the mediastinum after removal of mediastinal lipoma // Kyobu Geka. 2004;57(10):935–40.
Carter BW, Benveniste MF, Marom EM. Diagnostic approach to the anterior/prevascular mediastinum for radiologists // Mediastinum. 2019;3:18. doi:10.21037/med.2018.12.03
Punpale A, Pramesh CS, Jambhekar N et al. Giant mediastinal liposarcoma: a case report // Ann Thorac Cardiovasc Surg. 2006;12(6):425–7.
Lott-Limbach AA, Wakely PE.Jr. Mediastinal sarcomas: experience using fine needle aspiration cytopathology // Mediastinum. 2020;4:14. doi:10.21037/med-20-30.
Феденко А.А. Липосаркомы: морфологические подтипы, факторы прогноза и терапевтические опции // Современная онкология. 2016;18(3):52–58 [Fedenko AA. Liposarcomas: morphological subtypes, prognostic factors and therapeutic options // Journal of Modern Oncology. 2016;18(3):52–58 (In Russ.)].
Suster DI. The role of molecular pathology in mediastinal sarcomas // Mediastinum. 2020;4:33. doi:10.21037/med-20-39
Boland JM, Colby TV, Folpe AL. Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features // Am J Surg Pathol. 2012;36(9):1395–403. doi:10.1097/PAS.0b013e3182562bc1
Hirai S, Hamanaka Y, Mitsui N et al. Surgical resection of primary liposarcoma of the anterior mediastinum // Ann Thorac Cardiovasc Surg. 2008;14(1):38–41.
Paquette M, Truong PT, Hart J еt al. Primary sarcoma of the mediastinum: a report of 16 cases referred to the British Columbia Cancer Agency // J Thorac Oncol. 2010;5(6):898–906. doi:10.1097/jto.0b013e3181d8fe80
Okuno M, Kawashima M, Miura K et al. Resection of giant mediastinal liposarcoma using the hemi-clamshell incision // Gen Thorac Cardiovasc Surg. 2010;58(12):654–6. doi:10.1007/s11748-010-0584-0
Decker JR, de Hoyos AL, Decamp MM. Successful thoracoscopic resection of a large mediastinal liposarcoma // Ann Thorac Surg. 2011;92(4):1499–501. doi:10.1016/j.athoracsur.2011.02.051
Hamanaka K, Ohashi M, Nakamura T. Primary mediastinal dedifferentiated liposarcoma resected by lateral thoracotomy with video‐assisted thoracoscopic surgery // J Surg Case Rep. 2016;2016(1):rjv163. doi:10.1093/jscr/rjv163
Miura K, Hamanaka К, Matsuoka S et al. Primary mediastinal dedifferentiated liposarcoma: Five case reports and a review // Thorac Cancer. 2018;9(12):1733–1740. doi:10.1111/1759-7714.12888
Jones RL, Fisher C, Al‐Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy // Eur J Cancer. 2005;41(18):2853–60. doi:10.1016/j.ejca.2005.07.023
Setola E, Noujaim J, Benson C et al. Eribulin in advanced liposarcoma and leiomyosarcoma. Expert Rev Anticancer Ther. 2017;17(8):717–723. doi:10.1080/14737140.2017.1344098
Волков А.Ю., Неред С.Н., Любченко Л.Н. Забрюшинные неорганные липосаркомы; современный взгляд на проблему // Сибирский онкологический журнал. 2019;18(5):86–96 [Volkov AYu, Nered SN, Lyubchenko LN. Retroperitoneal non-organ liposarcomas: The modern concept. Siberian journal of oncology. 2019;18(5):86–96 (In Russ.)]. doi:10.21294/1814-4861-2019-18-5-86-96
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