Vol. 69 No. 3 (2023), CLINICAL CASES

Vol. 69 No. 3 (2023)

Experience with multitargeted antitumor vaccine in a child with diffuse midline glioma, H3 K27M-mutant

CLINICAL CASES

https://doi.org/10.37469/0507-3758-2023-69-3-555-564

Published 30.06.2023

Svetlana Kulyova ⁺⁻
Ksenia Borokshinova ⁺⁻
Irina Baldueva
Tatiana Nekhaeva
Anna Artemyeva
Natalia Efremova
Natalya Emelyanova ⁺⁻
Alexei Novik
Sergey Novikov⁺⁻
Mikhail Girshovich
Evgeny Senchurov ⁺⁻
Elvira Gumbatova ⁺⁻
Rina Khabarova
Elena Mikhailova
Yulia Semenova ⁺⁻
Gaziz Sakhautdinov ⁺⁻

Svetlana Kulyova

д.м.н., доцент, заведующий детским онкологическим отделением, ведущий научный сотрудник научного отдела инновационных методов терапевтической онкологии и реабилитации, профессор учебно-методического отдела ФГБУ «НМИЦ онкологии им. Н. Н. Петрова» Министерства здравоохранения Российской Федерации, заведующий кафедрой онкологии, детской онкологии и лучевой терапии ФГБУ «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации, главный детский специалист онколог Комитета по здравоохранению Санкт-Петербурга.

https://orcid.org/0000-0003-0390-8498

Ksenia Borokshinova

НМИЦ онкологии им. Н.Н.Петрова

https://orcid.org/0000-0002-5004-1543

Irina Baldueva

https://orcid.org/0000-0002-7472-4613

Tatiana Nekhaeva

https://orcid.org/0000-0002-7826-4861

Anna Artemyeva

https://orcid.org/0000-0002-2948-397X

Natalia Efremova

https://orcid.org/0000-0002-3533-2721

Natalya Emelyanova

научный сотрудник научного отдела онкоиммунологии ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России

https://orcid.org/0000-0002-0125-9263

Alexei Novik

https://orcid.org/0000-0002-2430-4709

Sergey Novikov

ФГБУ «НМИЦ онкологии им. Н.Н. Петрова»

https://orcid.org/0000-0002-7185-1967

Mikhail Girshovich

https://orcid.org/0000-0002-7925-9570

Evgeny Senchurov

ФГБУ «НМИЦ онкологии им. Н. Н. Петрова»

https://orcid.org/0000-0002-6742-5754

Elvira Gumbatova

ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России

https://orcid.org/0000-0002-9489-8311

Rina Khabarova

https://orcid.org/0000-0002-6433-8487

Elena Mikhailova

https://orcid.org/0000-0003-1081-5118

Yulia Semenova

ФГБУ «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации

https://orcid.org/0000-0002-7600-4732

Gaziz Sakhautdinov

врач детский онколог ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России, аспирант кафедры онкологии, детской онкологии и лучевой терапии ФГБУ «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации

https://orcid.org/0000-0003-4795-6969

##article.numberofdownloads## 389

##article.numberofviews## 727

pdf (Русский)

Keywords

children
diffuse midline glioma
H3 K27M-mutant
dendritic cell vaccine

How to Cite

Kulyova , S., Borokshinova , K., Baldueva , I., Nekhaeva , T., Artemyeva , A., Efremova , N., Emelyanova , N., Novik , A., Novikov, S., Girshovich , M., Senchurov , E., Gumbatova , E., Khabarova , R., Mikhailova , E., Semenova , Y., & Sakhautdinov , G. (2023). Experience with multitargeted antitumor vaccine in a child with diffuse midline glioma, H3 K27M-mutant. Voprosy Onkologii, 69(3), 555–564. https://doi.org/10.37469/0507-3758-2023-69-3-555-564

Abstract

Diffuse high-grade glioma is the most common highly malignant primary brain tumor with an extremely aggressive growth and an unfavorable prognosis.

The article describes a clinical case of a 10-year-old child with diffuse midline glioma, H3 K27M-mutant, who after standard chemoradiotherapy is designed as a maintenance therapy for a dendritic cell vaccine based on immunogenic carcinotesticular and GD2 antigens (CTA+ (cancer-testis antigen) GD2+ (ganglioside) vaccine). Tumor lysate was represented by glioblastoma cell culture with 96% GD2 expression. GM-CSF (granulocyte-macrophage colony-stimulating factor), IL4 (interleukin 4) and FNOα (tumor necrosis factor α) were used as the growth and differentiation factors of dendritic cells derived from peripheral blood monocytes.

Multitargeted immunotherapy with CTA+GD2+ vaccine apriori solves the evolution problem of phenotypic heterogeneity and has greater clinical and immunological efficacy in high-grade gliomas with their gradual immunoediting.

https://doi.org/10.37469/0507-3758-2023-69-3-555-564

##article.numberofdownloads## 389

##article.numberofviews## 727

pdf (Русский)

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