Vol. 69 No. 3 (2023), ORIGINAL ARTICLES. C. CLINICAL RESEARCH

Vol. 69 No. 3 (2023)

Results of treatment of patients with nasopharyngeal malignancies after superselective chemoembolization of tumor vessels

ORIGINAL ARTICLES. C. CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2023-69-3-487-496

Published 30.06.2023

Aleksandr Mitrofanov ⁺⁻
Zamira Radzhabova
Saydakhmed Radzhabov⁺⁻
Maxim Kotov⁺⁻
Olga Pnomareva⁺⁻
Mikhail Girshovich⁺⁻
Ekaterina Kostromina⁺⁻
Veronika Klimenko⁺⁻

Aleksandr Mitrofanov

НМИЦ онкологии им.Н.Н.Петрова

https://orcid.org/0000-0001-7490-4019

Zamira Radzhabova

https://orcid.org/0000-0002-6895-0497

Saydakhmed Radzhabov

Polenov Neurosurgical Research Institute – branch of the Almazov National Medical Research Centre, St. Petersburg, Russian Federation

https://orcid.org/0000-0002-9596-6507

Maxim Kotov

ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова» Минздрава России, Санкт-Петербург

https://orcid.org/0000-0002-2586-1240

Olga Pnomareva

National Medical Research Centre of Oncology n.a. N.N. Petrov, Saint Petersburg, Russia

https://orcid.org/0000-0002-7004-9630

Mikhail Girshovich

National Medical Research Centre of Oncology n.a. N.N. Petrov, Saint Petersburg, Russia

https://orcid.org/0000-0002-7925-9570

Ekaterina Kostromina

National Medical Research Centre of Oncology n.a. N.N. Petrov, Saint Petersburg, Russia

https://orcid.org/0000-0002-4245-687X

Veronika Klimenko

National Medical Research Centre of Oncology n.a. N.N. Petrov, Saint Petersburg, Russia

https://orcid.org/0000-0003-1079-4492

pdf (Русский)

Keywords

head and neck cancer
chemoembolization
combined tumor treatment
locally advanced nasopharyngeal carcinoma (NPC)

How to Cite

Mitrofanov , A., Radzhabova, Z., Radzhabov, S., Kotov, M., Pnomareva, O., Girshovich, M., Kostromina, E., & Klimenko, V. (2023). Results of treatment of patients with nasopharyngeal malignancies after superselective chemoembolization of tumor vessels. Voprosy Onkologii, 69(3), 487–496. https://doi.org/10.37469/0507-3758-2023-69-3-487-496

Abstract

Objective. Evaluate the effectiveness of superselective chemoembolization of tumor vessels in combination with chemotherapy and radiation therapy in patients with locally advanced malignant tumors of nasopharynx (NC).

Methods. A retrospective study with prospective follow-up was conducted, divided into two groups: in the СE+CRT group, the first stage was superselective chemoembolization of tumor vessels followed by combined chemoradiotherapy (CRT), adjuvant chemotherapy (AT), in the CRT group - CRT followed by AT. Effectiveness was evaluated by event-free survival (EFS) and overall survival (OS) 1 and 2 years after treatment.

Results. The study included 71 patients(28 patients with CE+CRT, 43 CRT). Average follow–up time for EFS was 29 months (IQR 12 - 50 months). One-year EFS was 88.7%(95%CI [69.0 – 96.2]) in the CE+CRT group, 76.5% (95%CI [60.8 – 86.6]) in the CRT group (p<0.01). One–year OS for the CE+CRT group was 96.3% (95%CI [76.5 - 99.5]), CRT group - 83.7% (95%CI [68.9 – 91.9])(p=0.03). Male sex is an independent clinical factor influencing the reduction of EFS (HR 3,734; 95%CI [1,262 – 11,050];p=0.02).

Conclusions. Our results show that chemoembolization of nasopharyngeal malignant tumor vessels provides an acceptable response rate in patients with locally advanced nasopharyngeal tumors and allows for chemotherapy in full doses, remote chemoradiotherapy in radical doses without long breaks. Further studies are needed to assess local control of nasopharyngeal tumors after treatment.

https://doi.org/10.37469/0507-3758-2023-69-3-487-496

pdf (Русский)

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