Glioma C6 perivascular changes of invasion structural parameters variation (research study).
Vol. 67 No. 1 (2021), ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH
Vol. 67 No. 1 (2021)

Glioma C6 perivascular changes of invasion structural parameters variation (research study).

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH
https://doi.org/10.37469/0507-3758-2021-67-1-144-149
Published 03.03.2022
Nikolay Kostenikov
Granov Russian Research Center of Radiology and Surgical Technologies
Violetta Dubrovskaya
Granov Russian Research Center of Radiology and Surgical Technologies
Elena Kovanko
Granov Russian Research Center of Radiology and Surgical Technologies
Olga Mirolyubova
Granov Russian Research Center of Radiology and Surgical Technologies
Marina Mukhina
Granov Russian Research Center of Radiology and Surgical Technologies
Yury Ilyushchenko
Granov Russian Research Center of Radiology and Surgical Technologies
Andrei Stanzhevsky
Granov Russian Research Center of Radiology and Surgical Technologies
Dmitry Maistrenko
Granov Russian Research Center of Radiology and Surgical Technologies
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Keywords

glioblastoma
microvessels
morphometry
peritumoral zones

How to Cite

Kostenikov, N., Dubrovskaya, V., Kovanko, E., Mirolyubova, O., Mukhina, M., Ilyushchenko, Y., Stanzhevsky, A., & Maistrenko, D. (2022). Glioma C6 perivascular changes of invasion structural parameters variation (research study). Voprosy Onkologii, 67(1), 144–149. https://doi.org/10.37469/0507-3758-2021-67-1-144-149
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Abstract

A comparative study of the structural characteristics of microvessels with a perivascular arrangement of tumor cells and microvessels with normal structure located in the peritumoral zones of an intracranially implanted glioblastoma ("glioma C6") was conducted. The study was performed on rats. Morphometric method was used to determine the area, internal diameter and length of microvessels for 21 days after the introduction of tumor cells into the brain of rats. Changes in the structure of microvessels with glioblastoma cells were registered throughout the entire observation period. The active role of perivascularly located tumor cells in the transformation of the structure and properties of microvessels involved in the process of glioblastoma invasion into brain tissue is considered.

Key words: glioblastoma, microvessels, morphometry, peritumoral zones.

https://doi.org/10.37469/0507-3758-2021-67-1-144-149
##article.numberofdownloads## 30
##article.numberofviews## 146
pdf (Русский)

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