Vol. 63 No. 2 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 2 (2017)

INTRAFRACTIONAL PROSTATE SHIFTS DURING STEREOTACTIC RADIATION THERAPY

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-2-287-293

Published 01.02.2017

Sergey Kanaev⁺⁻
Sergey Novikov⁺⁻
Roman Novikov⁺⁻
Yu. Melnik⁺⁻
N. Ilin⁺⁻
A. Filippov⁺⁻

Sergey Kanaev

N.N. Petrov Research Institute of Oncology

Sergey Novikov

N.N. Petrov Research Institute of Oncology

Roman Novikov

N.N. Petrov Research Institute of Oncology

Yu. Melnik

N.N. Petrov Research Institute of Oncology

N. Ilin

N.N. Petrov Research Institute of Oncology

A. Filippov

N.N. Petrov Research Institute of Oncology

##article.numberofdownloads## 101

##article.numberofviews## 401

PDF (Русский)

Keywords

PROSTATE CANCER
STEREOTACTIC RADIOTHERAPY
PLANNING

How to Cite

Kanaev, S., Novikov, S., Novikov, R., Melnik, Y., Ilin, N., & Filippov, A. (2017). INTRAFRACTIONAL PROSTATE SHIFTS DURING STEREOTACTIC RADIATION THERAPY. Voprosy Onkologii, 63(2), 287–293. https://doi.org/10.37469/0507-3758-2017-63-2-287-293

Abstract

In this study we analyzed prostate intrafraction motion during the course of stereotactic radiotherapy (STRT). STRT (5 fraction of 7.25Gy) was performed in 31 primary patients with prostate cancer. At least 3 gold fiducial markers were implanted in prostate of every patient 3-5 days before simulation. Prostate position on treatment table was verified with cone beam CT just before and immediately after the end of each radiotherapy session. This data help to determine prostate displacement in cranio-caudal, anterior-posterior and lateral axes. Average values of intra-fractional prostate displacement were as follows: 0,8+/-1,2mm - in cranio-caudal, 0.9+/-1,0mm - in lateral and 1.3+/-1,3mm - in anterior-posterior directions. In 5%-8,3% cases prostate displacement in cranio-caudal and lateral directions exceeded 2mm with maximal value of 5mm. In accordance with obtained average shifts we recommend following PTV margins: 1mm - in anterior-posterior and 3mm - in all other directions. In this case average intrafractional prostate shifts would not compromise dose delivery to prostate (V100 - 98%, D90 - 101%) and in comparison with standard (3mm, 5mm, 5mm, 5mm) margins would permit 16% reduction of rectum volume incorporated in 80% isodose. We propose that small average intrafractional displacement of prostate permits the use of narrower PTV margins without compromising coverage of the target and significant reduction of rectum volume covered by 80% isodose.

https://doi.org/10.37469/0507-3758-2017-63-2-287-293

##article.numberofdownloads## 101

##article.numberofviews## 401

PDF (Русский)

References

Канаев С.В., Новиков С.Н., Ильин Н.Д. и др. Опыт использования биодеградирующих спейсеров при проведении стереотаксической лучевой терапии у больных раком предстательной железы // Сборник тезисов II Всероссийского съезда по радиохирургии и стереотаксической радиотерапии. 3-4 июня, СПб. -Инфра-М, Москва. - 2016. - C. 41-42.

Новиков С.Н., Канаев С.В., Новиков РВ. и др. Вы-сокодозная брахитерапия в лечении больных раком предстательной железы / Учебное пособие, Санкт-Петербург - СПб:Издательство ГБОУ ВПО СЗГМУ им. И.И. Мечникова, 2016. - 40 с.

Alongi F, Fiorentino A., De Bari B. SBRT and extreme hypofractionation: A new era in prostate cancer treatments? // Rep Pract Oncol Radiother. - 2015 - Vol. 20 - P. 411-416.

DAmbrosio D.J., Pollack A., Harris E.E. et al. Assessment of external beam radiation technology for dose escalation and normal tissue protection in the treatment of prostate cancer // Int. J Radiat Oncol Biol Phys. - 2008. - Vol. 70. - P 671-677.

Demanes D.J., Ghilezan M.I. High-dose-rate Brachytherapy as monotherapy for prostate cancer // Brachytherapy. -2014. - Vol. 13 - P. 529-541.

Gez E., Cytron S., Ben Yosef R. et al. Application of an interstitial and biodegradable balloon system for prostate-rectum separation during prostate cancer radiotherapy: a prospective multi-center study // Radiat Oncol. - 2013. - Vol. 8. - P. 96.

Gunnlaugsson A., Kjellen E., Hagberg O., Thellenberg-Karlsson C., Widmark A., Nilsson P. Change in prostate volume during extreme hypo-fractionation analysed with MRI // Radiat Oncol. - 2014. - Vol. 9. - P. 22.

Fuller D.B. Prostate stereotactic body radiotherapy -methods, rationale, outcomes, and future directions // Chapter in Stereotactic body therapy. A practical guide. A Gaya, Mahadeva A. Sprinfler-Verlag, London - 2015. - P. 195-224.

Hoskin P.J., Colombo A., Henry A. et al. GEC/ESTRO recommendations on high dose rate afterloading brachytherapy for localised prostate cancer: An update // Radiother. Oncol. - 2013. - Vol. 107. - Р 325-332.

Kim D.V.N., Straka C., L. Cho C., Timmerman R.D. Stereotactic body radiation therapy for prostate cancer: review of experience of a multicenter phase I/II dose-escalation study // Front Oncol. - 2014. - Vol. 26. - №4. - P 319.

Martinez A.A., Gonzalez J., Ye H., Ghilezan M., Shetty S., Kernen K., Gustafson G., Krauss D., Vicini F., Kestin L. Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy // Int J Radiat Oncol Biol Phys. - 2011. - Vol. 79(2). - P. 363-370.

Skarsgard D., Cadman P., El-Gayed A., Pearcey R., Tai P., Pervez N., Wu J. Planning target volume margins for prostate radiotherapy using daily electronic portal imaging and implanted fiducial markers // Radiat Oncol. -2010. - Vol. 5. - P 52.

Stroom J.C., de Boer H.C., Huizenga H., Visser A.G. Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability // Int. J. Radiat. Oncol. Biol. Phys. - 1999. - Vol. 43(4). -P. 905-919.

van Herk M., Remeijer P, Rasch C., Lebesque J.V. The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy // Int. J. Radiat. Oncol. Biol. Phys. - 2000. - Vol. 47(4). - P 1121-1135.

Viani G.A., Stefano E.J., Afonso S.L. Higher-than-conventional radiation doses in localized prostate cance r treatment: a meta-analysis of randomized, controlled trials // Int. J. Radiat. Oncol. Biol. Phys. - 2009. - Vol. 74(5). - P. 1405-1418.

Xie Y, Djajaputra D., King C.R. et al. Intrafractional motion of the prostate during hypofractionated radiotherapy // Int. J. Radiat. Oncol. Biol. Phys. - 2008. - Vol. 72(1). - P 236-246.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

Andrey Arsenev, Sergey Novikov, Aleksey Barchuk, Sergey Kanaev, Anton Barchuk, S. Tarkov, Andrey Nefedov, K. Kostitsyn, K. Gagua, A. Nefedova, Nikolay Aristidov, LUNG CANCER DIAGNOSIS: NON-INVASIVE AND INVASIVE METHODS , Voprosy onkologii : Vol. 66 No. 1 (2020)
Roksana Ulyanova, A. Chernaya, Petr Krivorotko, Sergey Novikov, Sergey Kanaev, Anna Artemeva, L. Shevkunov, Stanislav Tyatkov, Vsevolod Danilov, DIFFERENTIAL DIAGNOSTICS OF BREAST PATHOLOGY USING CONTRAST ENHANCEMENT PATTERNS IN CONTRAST-ENHANCED SPECTRAL MAMMOGRAPHY , Voprosy onkologii : Vol. 66 No. 3 (2020)
Svetlana Kulyova , Ksenia Borokshinova , Irina Baldueva , Tatiana Nekhaeva , Anna Artemyeva , Natalia Efremova , Natalya Emelyanova , Alexei Novik , Sergey Novikov, Mikhail Girshovich , Evgeny Senchurov , Elvira Gumbatova , Rina Khabarova , Elena Mikhailova , Yulia Semenova , Gaziz Sakhautdinov , Experience with multitargeted antitumor vaccine in a child with diffuse midline glioma, H3 K27M-mutant , Voprosy onkologii : Vol. 69 No. 3 (2023)
Viktoriia Mortada, Peter Krivorotko, Vladimir Semiglazov, Roman Pesotsky, Alexander Emelyanov, Makhmud Mortada, Nikolay Amirov, Valentin Channov, Tengiz Tabagua, Larisa Gigolaeva, Sergey Yerechshenko, Alexander Komyahov, Kirill Nikolaev, Konstantin Zernov, Elena Ziltsova, Alexander Bessonov, Yana Bondarchuk, Diana Enaldieva, Vladislav Semiglazov, Katerina Busko, Sergey Novikov, Sergey Kanaev, Alexey Belyaev, Breast cancer. De-Escalating Breast Cancer Surgery. , Voprosy onkologii : Vol. 68 No. 3 (2022)
Petr Krivorotko, Konstantin Zernov, Ruslan Paltuev, Anna Artemeva, Yelena Turkevich, Yekaterina Busko, Vladislav Semiglazov, Sergey Novikov, Sergey Kanaev, Vladimir Semiglazov, Ye. Trufanova, Garik Dashyan, Zhanna Bryantseva, Vladimir Vorotnikov, Tengiz Tabagua, Aleksandr Komyakhov, Aleksandr Bessonov, Larisa Gigolaeva, Antonina Chernaya, Kseniya Beloborodova, Yelena Zhiltsova, Olga Ivanova, Vadim Ivanov, Kirill Nikolaev, R. Donskikh, SENTINEL LYMPH NODE BIOPSY IN EARLY BREAST CANCER: THE EXPERIENCE OF THE N.N. PETROV RESEARCH INSTITUTE OF ONCOLOGY , Voprosy onkologii : Vol. 63 No. 2 (2017)
Antonina Chernaya, Tatyana Shumakova, Yekaterina Busko, Nadezhda Popova, Anna Artemeva, Petr Krivorotko, Pavel Krzhivitskiy, Sergey Novikov, Sergey Kanaev, Viktoriya Bashlyk, MAMMOGRAPHY AND MAMMOSCINTIGRAPHY WITH 99M TC-MIBI IN THE DIAGNOSIS OF MULTICENTRIC BREAST CANCER , Voprosy onkologii : Vol. 63 No. 6 (2017)
Grigoriy Zinovev, Georgiy Gafton, Sergey Novikov, Ivan Gafton, Yekaterina Busko, Roman Kadyrleev, I. Grinenko, A. Elmurzaev, RESULTS OF TREATMENT OF LOCALLY RECURRING SOFT TISSUES SARCOMAS OF EXTREMITIES , Voprosy onkologii : Vol. 64 No. 3 (2018)
Игорь Чумаченко, Roman Murashko, Arthur Keshabyan, Petr Krivorotko, Sergey Novikov, Benefits of Intraoperative Radiation Therapy in the combined treatment of breast cancer , Voprosy onkologii : Vol. 69 No. 1 (2023)
Sergey Novikov, Roman Novikov, Nikolay Ilin, Yuriy Merezhko, Ekaterina Samartseva, Andrey Arseniev, Vladimir Protoschak, Vasiliy Karandashov, The first experience of clinical application of an animal collagen-based spacer of domestic production to optimize the radiation treatment for prostate cancer: indications, technique and complications , Voprosy onkologii : Vol. 68 No. 6 (2022)
Anton Zozulya, Sergey Novikov, Irina Baldueva, D. Girdyuk, Natalya Yemelyanova, Yelena Tyuryaeva, E. Fedosova, F. Antipov, A. Navoloka, Sergey Kanaev, Aleksey Belyaev, CHANGES IN THE IMMUNE STATUS OF PATIENTS WITH METASTATIC SOLID TUMORS DURING STEREOTACTIC RADIATION THERAPY , Voprosy onkologii : Vol. 66 No. 3 (2020)

1 2 3 4 > >>

INTRAFRACTIONAL PROSTATE SHIFTS DURING STEREOTACTIC RADIATION THERAPY

Keywords

How to Cite

Abstract

References

Most read articles by the same author(s)

Similar Articles