Vol. 63 No. 6 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 6 (2017)

IMPROVEMENT OF CERVICAL CANCER SCREENING USING DETERMINATION OF MICRORNA IN CYTOLOGICAL PREPARATIONS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-6-855-861

Published 01.06.2017

Yelena Bakhidze⁺⁻
Anastasiya Malek⁺⁻
Alla Mikhetko⁺⁻
Mikhail Ivanov⁺⁻
Roman Samsonov⁺⁻
Igor Berlev⁺⁻
P. Arkhangelskaya⁺⁻

Yelena Bakhidze

N.N. Petrov National Medical Research Center of Oncolog, yU. Mechnikov North-West State Medical University

Anastasiya Malek

N.N. Petrov National Medical Research Center of Oncolog, N.N. Petrov National Medical Research Center of Oncology

Alla Mikhetko

N.N. Petrov National Medical Research Center of Oncolog

Mikhail Ivanov

N.N. Petrov National Medical Research Center of Oncology

Roman Samsonov

N.N. Petrov National Medical Research Center of Oncolog

Igor Berlev

N.N. Petrov National Medical Research Center of Oncolog

P. Arkhangelskaya

N.N. Petrov National Medical Research Center of Oncolog, yU. Mechnikov North-West State Medical University

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Keywords

MICRORNA
CERVICAL INTRAEPITHELIAL NEOPLASIA
DIAGNOSIS

How to Cite

Bakhidze, Y., Malek, A., Mikhetko, A., Ivanov, M., Samsonov, R., Berlev, I., & Arkhangelskaya, P. (2017). IMPROVEMENT OF CERVICAL CANCER SCREENING USING DETERMINATION OF MICRORNA IN CYTOLOGICAL PREPARATIONS. Voprosy Onkologii, 63(6), 855–861. https://doi.org/10.37469/0507-3758-2017-63-6-855-861

Abstract

The sensitivity of cytological screening of cervical cancer, despite the ongoing technical improvements, remains quite low. It was showed that among women with smears, regarded as questionable cytological data of ASCUS, from 5% to 10%, in fact, they had severe dysplasia. The use of new molecular diagnostic methods can improve the effectiveness of screening of cervical cancer by improving the accuracy of diagnosis of the degree of dysplasia. Neoplastic transformation of the cervix epithelium is accompanied by specific changes in the profile of siRNA expression, the evaluation of which has a great diagnostic potential. In this study, the expression of 18 miRNA was analyzed. The correlation of the expression of five miRNAs (miR-375, miR-20a, miR-196b, miR145 and miR-126) with the degree of neoplasia of the cervix was established, which allowed them to be recommended for further investigation for the purpose of introduction as a diagnostic test at the stage of cytological screening.

https://doi.org/10.37469/0507-3758-2017-63-6-855-861

##article.numberofdownloads## 34

##article.numberofviews## 97

PDF (Русский)

References

Каприн А.Д. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). - М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2017. - 250 с.

Botezatu A., Goia-Rusanu C.D., Iancu I.V. et al. Quantitative analysis of the relationship between microRNA124a, -34b and -203 gene methylation and cervical oncogenesis // Mol. Med. Rep. - 2011. - Vol. 4. - № 1. - P. 121128.

Castellsague X., Pawlita M., Roura E., Marqal N. Prospective seroepidemiologic study on the role of human papillomavirus and other infections in cervical carcinogenesis: evidence from the cohort // Int. J. Cancer. - 2014. - Vol. 135(2). - P. 440-452.

Di Leva G., Garofalo M., Croce C. M. MicroRNAs in cancer // Annu. Rev. Pathol. - 2014. - Vol. 9. - P. 287-314.

Fang H., Shuang D., Yi Z., Sheng H., Liu Y. Up-regulated microRNA-155 expression is associated with poor prognosis in cervical cancer patients // Biomed Pharmacother. - 2016. - Vol. 83. - P. 64-69.

Han Y., Xu G.X., Lu H. et al. Dysregulation of miRNA-21 and their potential as biomarkers for the diagnosis of cervical cancer // Int. J. Clin. Exp. Pathol. - 2015. - Vol. 8. - № 6. - P. 7131-7139.

Hao M., Zhao W., Zhang L. et al. Low folate levels are associated with methylation-mediated transcriptional repression of miR-203 and miR-375 during cervical carcinogenesis // Oncol. Lett. - 2016. - Vol. 11(6). - P. 3863-3869.

Heejeong Lee, Kyu Rae Kim et al. MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix // World J. Surg. Oncol. - 2014. - Vol. 12. - P. 334.

Huang TH., Chu T.Y Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer // Oncogene. - 2014. - Vol. 33(28). - P. 3636-3647.

Gao D., Zhang Y., Zhu M. et al. miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China // PLoS One. - 2016. - Vol. 11(10).

Gocze K., Gombos K., Kovacs K. et al. MicroRNA expressions in HPV-induced cervical dysplasia and cancer // Anticancer Res. - 2015. - Vol. 35. - № 1. - P. 523-530.

Pedroza-Torres A., Lopez-Urrutia E., Garcia-Castillo V. et al. MicroRNAs in cervical cancer: evidences for a miRNA profile deregulated by HPV and its impact on radioresistance // Molecules. - 2014. - Vol. 19. - № 5. - P. 6263-6281.

Ribeiro J., Marinho-Dias J., Monteiro P. et al. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development // Biomed. Res. Int. - 2015. - Vol. 2015. - P 304584.

Shen Y., Li Y., Ye F. et al. Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues // Exp. Mol. Med. - 2011. - Vol. 43(6). - P. 358-366.

Tian Q., Li Y., Wang F. et al. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women // J. Natl. Cancer Inst. - 2014. - Vol. 106. - № 9. - DOI: 10.1093/jnci/dju241

Wang X., Tang S., Le S.Y et al. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth // PLoS One. - 2008. - Vol. 3 (7).

Wang X., Wang H.K., Li Y et al. MicroRNAs are biomarkers of oncogenic human papillomavirus infections // Proc. Natl. Acad. Sci U. S. A. - 2014. - Vol. 111. - № 11. - P. 4262-4267.

Wang L., Chang L., Li Z. et al. miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway // Med. Oncol. - 2014. - Vol. 31(5). - P. 934.

Wang L., Yu J., Xu J. et al. The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues // Gene. - 2015. - Vol. 554. - № 1. - P. 1-8.

Xin F., Liu P., Ma C-F A circulating serum miRNA panel as early detection biomarkers of cervical intraepithelial neoplasia // Eur. Rev. Med. Pharmacol. Sci. - 2016. - Vol. 20 (23). - P. 4846-4851.

Yang Y, Xie YJ., Xu Q. et al. Down-regulation of miR-1246 in cervical cancer tissues and its clinical significance // Gynecol. Oncol. - 2015. - Vol. 138 (3). - P. 683-688.

Zheng W., Liu Z., Zhang W., Hu X. miR-31 functions as an oncogene in cervical cancer // Arch Gynecol. Obstet. - 2015. - Vol. 292(5). - P. 1083-1089.

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