СONTRIBUTION OF POLYMORPHIC VARIATION OF ТP53 AND XRCC1 GENES TO THE SUSCEPTIBILITY TO BREAST CANCER FOR WOMEN OF KYRGYZ AND BELARUSIAN NATIONALITY - A COMPARATIVE STUDY ON MULTIFACTOR DIMENSIONALITY REDUCTION METHODS
Vol. 64 No. 1 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH
Vol. 64 No. 1 (2018)

СONTRIBUTION OF POLYMORPHIC VARIATION OF ТP53 AND XRCC1 GENES TO THE SUSCEPTIBILITY TO BREAST CANCER FOR WOMEN OF KYRGYZ AND BELARUSIAN NATIONALITY - A COMPARATIVE STUDY ON MULTIFACTOR DIMENSIONALITY REDUCTION METHODS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH
https://doi.org/10.37469/0507-3758-2018-64-1-95-101
Published 01.01.2018
Nazira Aldasheva
Kyrgyz-Russian Slavic UniversitY
Vyacheslav Kipen
Scientific Practical Centre of the State Committee of Forensic Expertises
Zhaynagul Isakova
Institute of Molecular Biology and Medicine
Sergey Melnov
Belarusian Research Center «Ecology»
Raisa Smolyakova
N.N. Alexandrov Republican Scientific Practical Center of Oncology and Medical RadiologY
Elnura Talaybekova
Institute of Molecular Biology and Medicine
Kyyal Makieva
National Center of OncologY
A. Aldashev
Institute of Molecular Biology and Medicine
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Keywords

BREAST CANCER
ODDS RATIO
POLYMORPHISM
REPAIR
CONTROL OF CELL CYCLE
KYRGYZ POPULATION
BELARUSIAN POPULATION
ETHNIC CHARACTERISTICS
TP53
XRCC1
MULTIFACTOR DIMENSIONALITY REDUCTION

How to Cite

Aldasheva, N., Kipen, V., Isakova, Z., Melnov, S., Smolyakova, R., Talaybekova, E., Makieva, K., & Aldashev, A. (2018). СONTRIBUTION OF POLYMORPHIC VARIATION OF ТP53 AND XRCC1 GENES TO THE SUSCEPTIBILITY TO BREAST CANCER FOR WOMEN OF KYRGYZ AND BELARUSIAN NATIONALITY - A COMPARATIVE STUDY ON MULTIFACTOR DIMENSIONALITY REDUCTION METHODS. Voprosy Onkologii, 64(1), 95–101. https://doi.org/10.37469/0507-3758-2018-64-1-95-101
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Abstract

Basing on Multifactor Dimensionality Reduction method we showed that polymorphic variants p.Q399R (rs25487, XRCC1) and p.P72R (rs1042522, TP53) correlated with increased risk of breast cancer for women from the Kyrgyz Republic and the Republic of Belarus. Cohort for investigation included patients with clinically verified breast cancer: 117 women from the Kyrgyz Republic (nationality - Kyrgyz) and 169 - of the Republic of Belarus (nationality - Belarusians). Group for comparison included (healthy patients without history of cancer pathology at the time of blood sampling) 102 patients from the Kyrgyz Republic, 185 - from the Republic of Belarus. Respectively genotyping of polymorphic variants p.Q399R (rs25487, XRCC1) and p.P72R (rs1042522, TP53) was done by PCR-RFLP. Analysis of the intergenic interactions conducted with MDR 3.0.2 software. Both ethnic groups showed an increase of breast cancer risk in the presence of alleles for SNPs Gln p.Q399R (XRCC1) in the heterozygous state: for the group “Kyrgyz” - OR=2,78 (95% CI=[1,60-4,82]), p=0,001; for the group “Belarusians” - OR=1,85 (95% СІ=[1Д1-2,82], p=0,004. Carriers with combination of alleles Gln (p.Q399R, XRCC1) and Pro (p.P72R, TP53) showed statistically significance increases of breast cancer risk as for patients from the Kyrgyz Republic (OR=2,89, 95% CI=[1,33-6,31]), so as for patients from the Republic of Belarus (OR=3,01, 95% CI=[0,79-11,56]).

https://doi.org/10.37469/0507-3758-2018-64-1-95-101
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