Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

SUBSTANTIATION OF THE MODEL FOR CALCULATING THE INDIVIDUAL DOSE OF CYTOSTATICS USING CT VOLUMETRY FOR ISOLATED LUNG CHEMIOPERFUSION WITH METASTASECTOMY

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-319-324

Published 01.03.2018

Yevgeniy Levchenko⁺⁻
VAN TIN⁺⁻
ChZhAN VEN⁺⁻
P. Kalinin⁺⁻
Tatyana Dubinina⁺⁻
Elvira Gumbatova⁺⁻
Nikita Levchenko⁺⁻
Lev Shevkunov⁺⁻
Andrey Mishchenko⁺⁻
Oleg Mamontov⁺⁻
Konstantin Senchik⁺⁻
Ya. Ulyanchenko⁺⁻

Yevgeniy Levchenko

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

VAN TIN

N.N. Petrov National Medical Research Center of Oncology

ChZhAN VEN

N.N. Petrov National Medical Research Center of Oncology

P. Kalinin

N.N. Petrov National Medical Research Center of Oncology

Tatyana Dubinina

N.N. Petrov National Medical Research Center of Oncology

Elvira Gumbatova

N.N. Petrov National Medical Research Center of Oncology

Nikita Levchenko

N.N. Petrov National Medical Research Center of Oncology

Lev Shevkunov

N.N. Petrov National Medical Research Center of Oncology

Andrey Mishchenko

N.N. Petrov National Medical Research Center of Oncology

Oleg Mamontov

N.N. Petrov National Medical Research Center of Oncology

Konstantin Senchik

N.N. Petrov National Medical Research Center of Oncology

Ya. Ulyanchenko

N.N. Petrov National Medical Research Center of Oncology

PDF (Русский)

Keywords

METASTATIC LUNG LESION
ISOLATED LUNG

How to Cite

Levchenko, Y., TIN, V., VEN, C., Kalinin, P., Dubinina, T., Gumbatova, E., Levchenko, N., Shevkunov, L., Mishchenko, A., Mamontov, O., Senchik, K., & Ulyanchenko, Y. (2018). SUBSTANTIATION OF THE MODEL FOR CALCULATING THE INDIVIDUAL DOSE OF CYTOSTATICS USING CT VOLUMETRY FOR ISOLATED LUNG CHEMIOPERFUSION WITH METASTASECTOMY. Voprosy Onkologii, 64(3), 319–324. https://doi.org/10.37469/0507-3758-2018-64-3-319-324

Abstract

In order to create conditions for increasing the effectiveness of treatment of patients with metastatic lung disease a new method for calculating the dose of antitumor drug for performing isolated chemo-perfusion of the lung with metasta-sectomy taking into account the anatomical features of patients and previous operations on the lung was developed. The study consisted of three stages. As a result of the first stage of the study the effectiveness of the software package was measured in the volume of lung patients based on the presence of a strong positive correlation between the volumes of left lungs (Rs = 0.91, p <0.001), right lungs (Rs = 0.94, p <0.001) during the primary and repeated CT chest. As a result of the second stage of the study a weakly positive relationship was found between the volume of right lungs and the surface area of patients’ bodies (Rs = 0.32-0.40, p <0.001) and a weakly positive relationship between the volume of left lungs and the surface area of the patients’ bodies (Rs = 0, 32-0,40, p <0,001), which confirms the inexpediency of dosing an antitumor drug for lung chemo-perfusion based on the body surface area of a patient. As a result of the third stage of the study a method for calculating the dose of melphalan and cisplatin for performing lung chemo-perfusion based on CT lung volumetry was developed.

https://doi.org/10.37469/0507-3758-2018-64-3-319-324

PDF (Русский)

References

Гафтон Г.И., Семилетова Ю.В., Сенчик К.Ю. и др. Перфузионные технологии в лечении больных меланомой кожи и саркомами мягких тканей конечностей // Вопросы онкологии. - 2015. - Т. 3. - С. 507-509.

Левченко Е.В., Сенчик К.Ю., Барчук А.С. и др. Изолированная химиоперфузия лёгкого по поводу мета стазов солидных опухолей // Онкохир. - 2012. - Т. 4. - С. 46-53.

Чиссов В.И., Трахтенберг А.Х., Пикин О.В. и др. Метастатические опухоли легких. - М., 2009. - 160 с.

Burt M.E., Liu D., Abolhoda A. et al. Isolated lung perfusion for patients with unresectable metastases from sarcoma: a phase I trial // Ann. Thorac. surg. - 2000. - Vol. 69. - P. 1542-1549.

Du Bois D., Du Bois E.F. A formula to estimate the approximate surface area if height and weight be known // Arch. Intern. Med. - 1916. - Vol. 17. - P. 863-871.

Hendriks J.M., Van Putte B.P, Grootenboers M. et al. Isolated lung perfusion for pulmonary metastases // Thorac. surg. clin. 2006. - Vol. 16. - P. 185-198.

Hendriks J.M., Grootenboers M.J., schramel F.M. et al. Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial // Ann. thorac. surg. - 2004. - Vol. 78. - P 1919-1926.

Hengst W.A., Hendriks J.M., Balduyck B. et al. Phase II Multicenter Clinical Trial of Pulmonary Metastasectomy and Isolated Lung Perfusion with Melphalan in Patients with Resectable Lung Metastases // J. thorac. oncol. - 2014. - Vol. 9 (10). - P 1547-1553.

Kouno T., Katsumata N., Mukai H. et al. standardization of the Body surface Area Formula to Calculate the Dose of Anticancer Agents in Japan // Jpn. J. Clin. oncol. - 2003. - Vol. 6. - P. 309-331.

Meeh K. oberflächenmessungen des menschlichen Körpers // Z. Biol. - 1879. - Vol. 15. - P 425-485.

Pastorino U., Buyse M., Friedel G. et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. The International 171 Registry of Lung Metastases // J. thorac. cardiovasc. surg. - 1997. - Vol. 133. - P. 37-49.

Putnam J.B. New and evolving treatment methods for pulmonary metastases // semin. Thorac. Cardiovasc. surg. - 2002. - Vol. 14. - P 49-56.

Ratto G.B., Toma s., Civalleri D. et al. Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas // J. thorac. cardiovasc. surg. - 1996. - Vol. 112. - P. 614-622.

Redlarski G., Palkowski A., Krawczuk M. Body surface area formulae: an alarming ambiguity // sci. Rep. - 2016. - Vol. 6.

schlich E., schumm M., schlich M. 3D-Body-scan als anthropometrisches Verfahren zur Bestimmung der spezifischen Körperoberfläche // Ernährungs Umschau. - 2010. - Vol. 4. P - 178-183.

schroder C., Fisher s., Pieck A.C. et al. Technique and results of hyperthermic (41 degrees C) isolated lung perfusion with high-doses of cisplatin for the treatment of surgically relapsing or unresectable lung sarcoma metastasis // Eur. j. cardiothorac. surg. - 2002. - Vol. 22. - P. 41-46.

Yu C.Y, Lin C.H., Yang YH. Human body surface area database and estimation formula // Burns. - 2010. - Vol. 36. - P. 616-629.

Van schil P.E., Hendriks J.M., Van Putte B.P. et al. Isolated lung perfusion and related techniques for the treatment of pulmonary metastases // Eur. j. cardiothoracic. surg. - 2008. - Vol. 33. - P. 487-496.

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