Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

CLINICAL EXPERIENCE OF USING BRACHYTHERAPY WITH HIGH DOSE RATE SOURCES FOR MONOTHERAPY IN PROSTATE CANCER PATIENTS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-366-373

Published 01.03.2018

Sergey Novikov⁺⁻
Sergey Kanaev⁺⁻
Roman Novikov⁺⁻
N. Ilin⁺⁻
M. Gotovchikova⁺⁻
M. Girshovich⁺⁻

Sergey Novikov

N.N. Petrov National Medical Research Center of Oncology

Sergey Kanaev

N.N. Petrov National Medical Research Center of Oncology

Roman Novikov

N.N. Petrov National Medical Research Center of Oncology

N. Ilin

N.N. Petrov National Medical Research Center of Oncology

M. Gotovchikova

N.N. Petrov National Medical Research Center of Oncology

M. Girshovich

N.N. Petrov National Medical Research Center of Oncology

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Keywords

PROSTATE CANCER
RADIOTHERAPY
HIGH-DOSE RATE BRACHYTHERAPY

How to Cite

Novikov, S., Kanaev, S., Novikov, R., Ilin, N., Gotovchikova, M., & Girshovich, M. (2018). CLINICAL EXPERIENCE OF USING BRACHYTHERAPY WITH HIGH DOSE RATE SOURCES FOR MONOTHERAPY IN PROSTATE CANCER PATIENTS. Voprosy Onkologii, 64(3), 366–373. https://doi.org/10.37469/0507-3758-2018-64-3-366-373

Abstract

The aim of the study: to evaluate efficacy and toxicity of interstitial high-dose-rate prostate brachytherapy when it was used as monotherapy for low-, intermediate risk prostate cancer.

Material and methods: 198 primary patients with low-, intermediate risk prostate cancer that were treated from 1.07.2012 to 01.07.2017 were included in the study. Two fractions of 13Gy were used in 67 men, 3 fractions of 11.5Gy -in the remaining 131 patients. The reported end points were overall/cancer-specific survival, biochemical control rates according to Phoenix definition. Toxicity was scored according to the RTOG scale.

Results: The median follow-up time was 28.7 [19.3; 36.6] (10.9-58.9) months. The 3-year biochemical control (nadir+2) was reached in 94.1% cases. Late grade III genito-urinary toxicity was represented by urethral strictures in 1.6% of evaluated patients. Grade III rectal toxicity was not mentioned. IIEF score before treatment was below 16 in 28.8% patients and after brachytherapy - in 52.9% cases.

Conclusion: high dose rate brachytherapy can be effectively and safely used for monotherapy of patients with low-, intermediate risk prostate cancer.

https://doi.org/10.37469/0507-3758-2018-64-3-366-373

##article.numberofdownloads## 36

##article.numberofviews## 182

PDF (Русский)

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