BINDING OF 3H-DMBA WITH BIOPOLYMERS OF MOTHER AND FETUS TISSUES IN RATS DURING TRANSPLACENTAL CARCINOGENESIS

ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-5-683-687

Published 01.05.2018

Sergey Ivanov⁺⁻
Valeriy Aleksandrov⁺⁻
Aleksandr Semenov⁺⁻
Viktor Bespalov⁺⁻

Sergey Ivanov

Russian Research Centre for Radiology and Surgical Technologies

Valeriy Aleksandrov

N.N. Petrov Research Institute of Oncology, ITMO University

Aleksandr Semenov

Russian Research Centre for Radiology and Surgical Technologies, N.N. Petrov Research Institute of Oncology

Viktor Bespalov

N.N. Petrov Research Institute of Oncology, ITMO University

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Keywords

TRANSPLACENTAL CARCINOGENESIS
12-DIMETHYLBENZ[A]ANTHRACENE
TARGET ORGANS
LIPIDS
NUCLEIC ACIDS
PROTEINS

How to Cite

Ivanov, S., Aleksandrov, V., Semenov, A., & Bespalov, V. (2018). BINDING OF 3H-DMBA WITH BIOPOLYMERS OF MOTHER AND FETUS TISSUES IN RATS DURING TRANSPLACENTAL CARCINOGENESIS. Voprosy Onkologii, 64(5), 683–687. https://doi.org/10.37469/0507-3758-2018-64-5-683-687

Abstract

The aim of the study was to establish regularities of activated 3H-7,12-dimetilbenz(a)antratcene (DMBA) translocation in the major biopolymers of target and non-target organs at the initiation stage of transplacental carcinogenesis. DMBA was administered i.p. to rats on the 21th day of the pregnancy. Analysis of liver and kidney tissues of mothers, as well as liver, kidney, and brain of offspring was performed at temporal points of 1 hr to 14 days after single carcinogen administration. A regular, but transient non-specific accumulation of DMBA-radioactivity in the lipid fraction mainly embryonic tissues was observed during the first 6 hrs after administration of the labeled carcinogen. By 6 hrs, the maximum increase of label in RNA of embryonic brain and kidney (target organ for tumor induction) was observed and then, from 6 to 12 hrs, an increase occurred in the number of radioactive DNA adducts of fetus that was maintained for 24 hrs in these tissues. Increased accumulation of label in proteins of embryonic kidney was recorded from 6 to 24 hrs, and brain - from 12 to 24 hrs after administration of 3H-DMBA and on the 7th day in proteins of these organs of newborn rats.

https://doi.org/10.37469/0507-3758-2018-64-5-683-687

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##article.numberofviews## 117

PDF (Русский)

References

Кит О.И., Кириченко Е.Ю., Кириченко Ю.Г. и др. Длинные некодирующие РНК, ассоциированные с канцерогенезом: биологическое значение и перспективы применения в диагностике // Клин. лаб. диагностика. - 2016. - Т. 61. - № 1. - С. 13-16.

Строев Е.А., Макарова В.Г, Матвеева И.В. Практикум по биологической химии. - М.: МИА, 2012.

Autrup H. Transplacental transfer of genotoxins and transplacental carcinogenesis // Env. Health Perspect. - 1993. - Vol. 101. - Suppl. 2. - P. 33-38.

Catto J.W.F., Alcaraz A., Bjartell A.S. et al. MicroRNA in prostate, bladder, and kidney cancer: a systematic review // European Urology. - 2011. - Vol. 59. - № 5. - P. 671681.

Devanesan P.D., RamaKrishna N.V., Padmavathi N.S. et al. Identification and quantitation of 7,12-dimethylbenz-[a]anthracene-DNA adducts formed in mouse skin // Chem. Res. Toxicol. -1993. - Vol. 6. - № 3. - P. 364-371.

Diwan B.A., Rice J.M. Effect of stage of development on frequency and pathogenesis of kidney tumors induced in Noble (Nb) rats exposed prenatally or neonatally to N-nitrosoethylurea // Carcinogenesis. - 1995. - Vol. 16. -№ 9. - P. 2023-2028.

Gutscher T., Diederichs S. The hallmark of cancer. A long non-coding RNA point of view // RNA Biology. - 2012. -Vol. 9. - № 6. - P. 703-719.

Hung C.-H., Chiu Y-C., Chen C.-H., Hu T.-H. MicroRNAs in hepatocellular carcinoma: carcinogenesis, progression, and therapeutic target // BioMed Res. International. - 2014. - Vol. 2014. - Article ID 486407. - P. 1-11. - DOI: 10.1155/2014/486407

Iyama T., Wilson III D.M. DNA repair mechanisms in dividing and non-dividing cells // DNA repair (Amst). - 2013. - Vol. 12. - № 8. - P 620-636.

Moller H.G., Rasmussen A.P, Andersen H.H. et al. A systemic review of microRNA in glioblasroma multiforme: Micro-modulators in the mesenchymal mode of migration and invasion // Molec. Neurobiol. - 2013. - Vol. 47. - № 1. - P. 131-144.

Niazi S.K., Hussain M. Disposition kinetics of 7,12-dimethylbenz(a)anthracene in rats // Biopharmaceutics Drug Disposition. - 1992. - Vol. 13. - P. 591-596.

Rice J.M., Wilbourn J.D. Tumors of the nervous system in carcinogenic hazard identification // Toxicol. Pathology. -2000. - Vol. 28. - № 1. - P. 2002-2014.

Takahashi H., Carninci P. Widespread genome transcription: New possibilities for RNA therapies // Biochem. Biophys. Res. Commun. - 2014. - Vol. 452. - № 2. - P. 294-301.

Todorovic R., Ariese F., Denavasan P et al. Determination of benzo[a]pyrene- and 7, 12-dimethylbenz[a]anthracene-DNA adducts formed in rat mammary glands // Chem. Res. Toxicol. - 1997. - Vol. 10. - № 9. - P 941-947.

Veskoukis A.S., Nsansakis A.M., Kouretas D. Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration // Cell Stress Chaperones. - 2012. - Vol. 17. -№ 1. - P 11-21.

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