Vol. 65 No. 3 (2019), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 65 No. 3 (2019)

COMBINED TREATMENT OF LOCALLY ADVANCED NONSMALL CELL LUNG CANCER AND MOLECULAR ASPECTS OF CHEMORESISTANCE

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-3-393-398

Published 01.03.2019

Sergey Miller⁺⁻
Yevgeniy Rodionov⁺⁻
Sergey Tuzikov⁺⁻
Leonid Yefteev⁺⁻
Yevgeniy Yumov⁺⁻
Matvey Tsyganov⁺⁻
Nikolay Litvyakov⁺⁻
Irina Frolova⁺⁻
Nadezhda Cherdyntseva⁺⁻
Svetlana Velichko⁺⁻
Aleksey Goldberg⁺⁻

Sergey Miller

Cancer Research Institute, Tomsk NRMC

Yevgeniy Rodionov

Cancer Research Institute, Tomsk NRMC, Siberian State Medical University

Sergey Tuzikov

Cancer Research Institute, Tomsk NRMC, Siberian State Medical University

Leonid Yefteev

Cancer Research Institute, Tomsk NRMC

Yevgeniy Yumov

Buryat Republican oncological dispensary

Matvey Tsyganov

Cancer Research Institute, Tomsk NRMC

Nikolay Litvyakov

Cancer Research Institute, Tomsk NRMC, National Research Tomsk State University

Irina Frolova

Cancer Research Institute, Tomsk NRMC

Nadezhda Cherdyntseva

Cancer Research Institute, Tomsk NRMC, National Research Tomsk State University

Svetlana Velichko

Cancer Research Institute, Tomsk NRMC

Aleksey Goldberg

Cancer Research Institute, Tomsk NRMC

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Keywords

COMBINED TREATMENT
NON-SMALL CELL LUNG CANCER
NEOADJUVANT CHEMOTHERAPY
CHEMORESISTANCE
MONORESISTANCE GENES
ABC-TRANSPORTERS

How to Cite

Miller, S., Rodionov, Y., Tuzikov, S., Yefteev, L., Yumov, Y., Tsyganov, M., Litvyakov, N., Frolova, I., Cherdyntseva, N., Velichko, S., & Goldberg, A. (2019). COMBINED TREATMENT OF LOCALLY ADVANCED NONSMALL CELL LUNG CANCER AND MOLECULAR ASPECTS OF CHEMORESISTANCE. Voprosy Onkologii, 65(3), 393–398. https://doi.org/10.37469/0507-3758-2019-65-3-393-398

Abstract

We analyzed the results of treatment of 68 patients with NSCLC stage III, of which the main group included 36 patients with perioperative chemotherapy vinorelbin / carboplatin. The control group included 32 patients who underwent only surgical treatment. The correlation of monoresistance and multidrug resistance (MDR) genes expression with clinical and morphological parameters of tumor process and with the frequency of distant metastasis was studied. Results. The three - year relapse-free and overall survival in the study group was 60.0±13.8% and 80.0±8.5 %, in the control group-35.7±25.4% and 50.0±18.9%, respectively. The relationship between the expression genes of the studied MDR genes and monoresistance with the main clinical and morphological parameters of patients and the frequency of metastasis was established. Conclusion. The results of the study show a higher efficiency of combined treatment of NSCLC due to a significant reduction in the number of long-term metastases and local recurrences and, accordingly, improved overall and relapse-free survival. Monoresistance anMDR genes play an important role in NSCLC chemoresistance, so the study of the expression level of these genes is important for the planning of personalized treatment.

https://doi.org/10.37469/0507-3758-2019-65-3-393-398

##article.numberofdownloads## 38

##article.numberofviews## 606

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