Ключевые слова
Как цитировать
Аннотация
Злокачественная опухоль представляет собой многокомпонентную пространственно сложно организованную систему, которая характеризуется индивидуальными особенностями для каждого пациента. Создание клеточной модели in vitro, максимально приближенной по структуре и свойствам к естественной опухолевой системе, позволит приблизиться к решению таких практических и теоретических задач современной онкологии, как выявление биологических закономерностей опухолевого роста, особенностей поведения клеток иммунной системы, тестирование потенциальных противоопухолевых препаратов, определение эффективности методов химио-, радио-, фотодинамической, таргетной и иммунотерапии. Такой моделью могут служить трёхмерные клеточные структуры - сфероиды (тумороиды). В обзоре представлены данные об особенностях трехмерного клеточного моделирования, характеристиках существующих 3D моделей и их пригодности в экспериментальных и клинических исследованиях.
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