СОЗДАНИЕ ТРЁХМЕРНЫХ КЛЕТОЧНЫХ МОДЕЛЕЙ ДЛЯ РЕШЕНИЯ ТЕОРЕТИЧЕСКИХ И ПРАКТИЧЕСКИХ ЗАДАЧ СОВРЕМЕННОЙ ОНКОЛОГИИ
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Ключевые слова

СФЕРОИДЫ
ТУМОРОИДЫ
СОЛИДНЫЕ ОПУХОЛИ

Аннотация

Злокачественная опухоль представляет собой многокомпонентную пространственно сложно организованную систему, которая характеризуется индивидуальными особенностями для каждого пациента. Создание клеточной модели in vitro, максимально приближенной по структуре и свойствам к естественной опухолевой системе, позволит приблизиться к решению таких практических и теоретических задач современной онкологии, как выявление биологических закономерностей опухолевого роста, особенностей поведения клеток иммунной системы, тестирование потенциальных противоопухолевых препаратов, определение эффективности методов химио-, радио-, фотодинамической, таргетной и иммунотерапии. Такой моделью могут служить трёхмерные клеточные структуры - сфероиды (тумороиды). В обзоре представлены данные об особенностях трехмерного клеточного моделирования, характеристиках существующих 3D моделей и их пригодности в экспериментальных и клинических исследованиях.

https://doi.org/10.37469/0507-3758-2019-65-5-629-637
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