ОЦЕНКА ЭФФЕКТИВНОСТИ СОВРЕМЕННОЙ ИММУНОТЕРАПИИ
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Ключевые слова

МОДУЛЯТОРЫ ИММУННОГО СИНАПСА
ПСЕВДОПРОГРЕССИРОВАНИЕ
ГИПЕРПРОГРЕССИРОВАНИЕ

Аннотация

Ингибиторы контрольных точек иммунного ответа являются наиболее перспективной опцией лечения для многих гистологических подтипов злокачественных новообразований, обеспечивая длительный объективный ответ и увеличение общей выживаемости. В настоящее время появляется все больше данных о специфической гетерогенности клинических и радиологических ответов на фоне иммунотерапии, таких как псевдопрогрессирование и гипепрогрессирование. Учитывая данные феномены, перед клиницистом встает серьезный вопрос о необходимости выделения определенной когорты пациентов, для которых терапия иммуноонкологическими препаратами будет максимально эффективной и безопасной. Данный обзор демонстрирует результаты исследований, описывающие упомянутые феномены.
https://doi.org/10.37469/0507-3758-2020-66-3-211-217
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