Ключевые слова
Как цитировать
Аннотация
Особый интерес вызывают исследования по применению дистанционной лучевой терапии или химиолучевой терапии в сочетании с локальной гипертермией, результаты которых свидетельствуют о повышении непосредственной эффективности лучевой терапии за счет выраженной регрессии опухоли, а также увеличении длительности безрецидивного периода для ряда локализаций. Молекулярные механизмы эффективности локальной гипертермии в составе комбинированного лечения у больных злокачественными новообразованиями с метаболическими нарушениями недостаточно изучены. Эти механизмы могут быть ассоциированы с изменениями на уровне клетки (особенности системы репарации ДНК в опухоли при ожирении; miRNA в опухоли, ассоциированные с терморадиорезистентностью на фоне ожирения; стволовые клетки в опухоли на фоне ожирения, циркулирующие опухолевые клетки), а также с внеклеточными факторами, которые в свою очередь можно разделить на растворимые компоненты биологических жидкостей (например, плазмы крови, асцитической жидкости) и внеклеточные везикулы. Проблемы при проведении терапии больных злокачественными новообразованиями с метаболическими нарушениями связаны с отсутствием клинических рекомендаций по использованию локальной гипертермии, с недостаточной разработанностью методических подходов (способов и техник нагрева, длительностью сеанса, необходимыми температурам и количеством процедур), а также с не изученностью факторов прогноза эффективности комбинированного лечения.
Библиографические ссылки
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