Vol. 63 No. 4 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 4 (2017)

DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-4-614-621

Published 01.04.2017

Igor Berlev⁺⁻
Yekaterina Nekrasova⁺⁻
Gayk Mkrtchyan⁺⁻
Yevgeniya Bezhanova⁺⁻
Katran Guseynov⁺⁻
Yelena Ulrikh⁺⁻
Viktoriya Bashlyk⁺⁻
Anna Artemeva⁺⁻
Tatyana Semiglazova⁺⁻
Aleksandra Kondakova⁺⁻
Andrey Mishchenko⁺⁻
Nikolay Mikaya⁺⁻
Adiliya Urmancheeva⁺⁻
Nikolay Bondarev⁺⁻
O. Smirnova⁺⁻

Igor Berlev

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Yekaterina Nekrasova

N.N. Petrov Research Institute of Oncology

Gayk Mkrtchyan

N.N. Petrov Research Institute of Oncology

Yevgeniya Bezhanova

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Katran Guseynov

N.N. Petrov Research Institute of Oncology

Yelena Ulrikh

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Viktoriya Bashlyk

N.N. Petrov Research Institute of Oncology

Anna Artemeva

N.N. Petrov Research Institute of Oncology

Tatyana Semiglazova

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Aleksandra Kondakova

N.N. Petrov Research Institute of Oncology

Andrey Mishchenko

N.N. Petrov Research Institute of Oncology

Nikolay Mikaya

N.N. Petrov Research Institute of Oncology

Adiliya Urmancheeva

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Nikolay Bondarev

N.N. Petrov Research Institute of Oncology

O. Smirnova

N.N. Petrov Research Institute of Oncology

PDF (Русский)

Keywords

LOCALLY ADVANCED CERVICAL CANCER
DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY
PATHOMORPHOLOGICAL RESPONSE
YPCR
CR

How to Cite

Berlev, I., Nekrasova, Y., Mkrtchyan, G., Bezhanova, Y., Guseynov, K., Ulrikh, Y., Bashlyk, V., Artemeva, A., Semiglazova, T., Kondakova, A., Mishchenko, A., Mikaya, N., Urmancheeva, A., Bondarev, N., & Smirnova, O. (2017). DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES. Voprosy Onkologii, 63(4), 614–621. https://doi.org/10.37469/0507-3758-2017-63-4-614-621

Abstract

In 24 patients (mean age 48 years) with locally advanced cervical cancer there were studied the efficacy and toxicity of 3 cycles of neoadjuvant dose-intensive chemotherapy with cisplatin (75 mg/m²) and doxorubicin (35 mg/m²) administered intravenously on the first day of a two- week cycle with the support of colony-stimulating factors. An important criterion for the inclusion in this study of patients with locally advanced cervical cancer (T1b2-2bN0-1M0) was the absence of infiltration of the anterior parameters according to the gynecological examination and MRI studies. An objective response to treatment was registered in 72.7 % of cases. Progression of the disease was not detected in any case. Conducting neoadjuvant drug therapy allowed performing radical surgical intervention in 95.4 % of patients. The pathomorphlogical response of tumor of varying severity was 40.9 %. In 9.1 % complete clinical regression of tumor was confirmed by a complete pathomor-phological response (CR). The dose-intensive regimen of chemotherapy did not lead to a significant increase of complications on the drug and surgical stages. An analysis showed that dose-intensive neoadjuvant chemotherapy is a highly effective method in treatment for locally advanced cervical cancer.

https://doi.org/10.37469/0507-3758-2017-63-4-614-621

PDF (Русский)

References

Ашрафян Л.А., Антонова И.Б., Алешикова О.И. и др. Диагностические критерии и факторы прогноза эффективности неоадьювантной химиотерапии местнораспространенного рака шейки матки (IIb-IIIb стадии) // Опухоли женской репродуктивной системы. - 2007. - № 4. - С. 63-71.

Ашрафян Л.А., Антонова И.Б., Алешикова О.И. и др. Хирургический этап как один из основных компонентов в комплексном лечении рака шейки матки IIb-IIIb стадии // Рос. онкол. журн. - 2007. - № 3. - С. 21-25.

Ермакова Н.А. Роль химиотерапии на различных этапах лечения рака шейки матки // Практическая онкология. - 2002. - Т. 3. - № 3. - С. 2011-2019.

Коломиец Л.А., Чуруксаева О.Н. Роль химиотерапии в лечении местно-распространенных форм рака шейки матки // Сибирский онкологический журнал. - 2006. -Т. 17. - № 1. - С. 61-63.

Кузнецов В.В., Лебедев А.И., Горхов К.Ю. и др. Хирургия инвазивного рака шейки матки //Практическая онкогинекология: избранные лекции / под ред. А.Ф. Урманчеевой и др. - СПб., 2008. - С. 142-147.

Геньшенина А.П., Гоисеенко Т.И., Ушакова Н.Д. Возможности оптимизации предоперационной полихимиотерапии у больных инвазивным раком шейки матки // Злокачественные опухоли. - 2014. - № 3. - С. 30-36.

Новикова Е.Г. Опухоли женских половых органов / Новикова Е.Г., В.А. Антипов, О.В. Чулкова и др. // Онкология. Национальное руководство / под ред. акад. РАГН В.И. Чиссова, акад. РАН и РАГН Н.И. Давыдова. - Г.: ГЭОТАР-Гедиа, 2008. - С. 812-827.

Cаевец В.В., Важенина А.В., Жарова А.В. и др. Особенности многокомпонентного лечения местно-распространенного рака шейки матки с учетом гистологического строения опухоли // Злокачественные опухоли. - 2014. - № 3. - С. 40-45.

Чуруксаева О.Н., Коломиец Л.А. Неоадъювантная химиотерапия с включением гемцитабина в лечении местнораспространенного рака шейки матки // Вестник РОНЦ им Н.Н. Блохина РАГН. - 2010. - Т. 21. - № 2. - С. 75-81.

Чуруксаева О.Н., Коломиец Л.А. Неоадъювантная химиотерапия при лечении местнораспространенного рака шейки матки // Сибирский онкологический журнал. - 2013. - Т. 56. - № 2. - С. 18-24.

Gong L., Zhang J.-W., Yin R.-T. et al. Safety and Efficacy of Neoadjuvant Chemotherapy Followed by Radical Sur gery Versus Radical Surgery Alone in Locally Advanced Cervical Cancer Patients // Int. J. Gynecol. Cancer. - 2016. - Vol. 26. - № 4. - P 722-728.

Panici P.B., Greggy S., Colombo A. et al. Neoadjuvant сhеmotherapy and Radical Surgery Versus Exclusive Radiotherapy in Locally Advanced Squamous Cell Cervical Cancer: Results From the Italian Multicenter Randomized Study // J. Clin. Oncol. - 2002. - Vol. 20. - P. 179-188.

Panici P.B., Zullo M.A., Muzii L. et al. The role of neoadjuvant chemotherapy followed by radical surgery in the treatment of locally advanced cervical cancer // Eur. J. Gynecol Oncol. - 2003. - Vol. 24. - P 467-470.

Panici P.B., Bellati F., Pastore M. An update in neoadjuvant chemotherapy in cervical cancer // Gynecol. Oncol. - 2007. - Vol. 107. - Issue 1. - Suppl. P. S20-S22.

Panici P.B., Palaia I., Marchetti C. et al. Dose-Dense Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: A Phase II Study // Oncology. - 2015. - № 89. - P. 103-110.

Rob L., Skapa P., Robova H. Fertility-sparing surgery in patients with cervical cancer. // Lancet Oncol. - 2011. -Vol. 12. - P. 192-200.

Robova H., Pluta M., Hrehorcak M. et al. High dose density chemotherapy followed by simple trachelectomy: full-term pregnancy // Int. J. Gynecol. Cancer. - 2008. - Vol. 18. - P. 1367-1371.

Robova H., Rob L., Halaska M.J. et al. Review of neoadjuvant chemotherapy and trachelectomy: which cervical cancer patients would be suitable for neoadjuvant chemotherapy followed by fertility-sparing surgery // Curr. Oncol. Rep. - 2015. - Vol. 17. - Iss. 5. - P. 446-450.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© АННМО «Вопросы онкологии», Copyright (c) 2017

Most read articles by the same author(s)

Roksana Ulyanova, A. Chernaya, Petr Krivorotko, Sergey Novikov, Sergey Kanaev, Anna Artemeva, L. Shevkunov, Stanislav Tyatkov, Vsevolod Danilov, DIFFERENTIAL DIAGNOSTICS OF BREAST PATHOLOGY USING CONTRAST ENHANCEMENT PATTERNS IN CONTRAST-ENHANCED SPECTRAL MAMMOGRAPHY , Voprosy onkologii : Vol. 66 No. 3 (2020)
Boris Kasparov, Tatyana Semiglazova, Denis Kovlen, Gennadiy Ponomarenko, Valeriya Klyuge, Anton Krutov, Vladislav Osetnik, M. Tynkasova, Kristina Kondrateva, O. Zaozerskiy, Vladislav Semiglazov, A. Nosov, Aleksey Belyaev, REHABILITATION OF PATIENTS WITH PROSTATE CANCER , Voprosy onkologii : Vol. 66 No. 2 (2020)
Tatyana Semiglazova, Yevgeniya Tsyrlina, Artem Poltoratskiy, Yekaterina Busko, Vladislav Semiglazov, Anna Artemeva, Sergey Ivanov, Lev Bershteyn, Vladimir Anisimov, Aleksey Belyaev, Vladimir Semiglazov, V. Kostorov, Aleksey Novik, Boris Kasparov, Mikhail Osipov, Petr Krivorotko, Veronika Klimenko, Garik Dashyan, Ruslan Paltuev, Yelena Zhiltsova, Tengiz Tabagua, Aleksandr Komyakhov, Kirill Nikolaev, Viktoriya Bashlyk, Roman Donskikh, V. Apollonova, MELATONIN AND METFORMIN IN NEOADJUVANT HORMONOTHERAPY IN LOCALLY ADVANCED BREAST CANCER , Voprosy onkologii : Vol. 64 No. 5 (2018)
Valentina Chulkova, Yelena Pestereva, Elvira Karpova, Nelli Khrustaleva, Tatyana Semiglazova, M. Rogachev, Aleksey Belyaev, EMOTIONAL BURNOUT AND ISSUES OF PROFESSIONAL PSYCHOLOGICAL TRAINING OF ONCOLOGISTS , Voprosy onkologii : Vol. 66 No. 2 (2020)
Ekaterina Busko , Elvira Lyubimskaya , Kseniya Kozubova , Victoriya Smirnova, Anna Artemeva, Ekaterina Kostromina, Roman Kadyrleev , Indira Kurganskaya , Pavel Grishko , Grigory Zinovev , Vladimir Ryazanov , Sergey Bagnenko , Ilya Burovick , A Rare Case Report: Cavernous Hemangioma of the Breast. Ultrasound and Mammography Features, Challenges in Differential Diagnosis , Voprosy onkologii : Vol. 69 No. 4 (2023)
Mariia Urezkova , Tatyana Semiglazova , Anna Artemyeva , Asel Kudaybergenova , Vladislav Semiglazov , Petr Krivorotko, Vladimir Semiglazov , Results of FISH study of HER2 in triple-positive breast cancer , Voprosy onkologii : Vol. 69 No. 2 (2023)
Aleksandr Emelianov, Petr Krivorotko, Elena Zhiltsova, Aleksandr Komiakhov, Ekaterina Busko, Pavel Krzhivitskii, Anna Artemeva, Antonina Chernaia, Sergei Novikov, Larisa Gigolaeva, Tengiz Tabagua, Kirill Nikolaev, Roman Pesotskii, Viktoriia Mortada, Nikolai Amirov, Valentin Channov, Sergei Ereshchenko, Roman Donskikh, Konstantin Zernov, Vladimir Semiglazov, Axillary surgery after neoadjuvant chemotherapy in breast cancer patients downstaging from cN+ to ycN0 , Voprosy onkologii : Vol. 68 No. 3 (2022)
Tatiana Gorodnova, Anna Sokolenko, Kh.B Kotiv , Alexandr Ivantsov, Maria Yakovleva , Olga Lavrinovich, Nikolay Mikaya, Zaur Ibragimov, Yurii Trifanov, Nikolay Bondarev , Olga Smirnova, Konstantin Guseinov, Elena Bakhidze, Irina Meshkova, Elena Konstantinova, Adel Urmancheeva, Igor Berlev, Alexei Belyaev, Evgeny Imyanitov, The prospective randomized trial evaluating the efficacy of the mitomycin C and cisplatin regimen (MP) versus standard first-line chemotherapy in patients with advanced BRCA1/2-associated ovarian cancer (NCT04747717) , Voprosy onkologii : Vol. 68 No. 5 (2022)
Anton Zozulia, Irina Baldueva, Anna Artemeva, Sergei Novikov, Anastasiia Muravtseva, Dmitrii Girdiuk, Natalia Emelianova, Elena Tiuriaeva, Elena Fedosova, Filipp Antipov, Andrei Arsenev, Mikhail Girshovich, Sergei Kanaev, Aleksei Beliaev, Changes of immune status in patients with different PD-L1 expression after stereotactic body radiation therapy of oligometastasis , Voprosy onkologii : Vol. 67 No. 6 (2021)
Tatyana Rogovskaya, Anna Sidoruk, Irina Meshkova, Yekaterina Nekrasova, Zaur Ibragimov, Igor Berlev, Adiliya Urmancheeva, LYMPHOCYSTS AFTER LAPAROSCOPIC AND OPEN HYSTERECTOMY WITH PELVIC LYMPHADENECTOMY FOR ENDOMETRIAL CANCER , Voprosy onkologii : Vol. 63 No. 3 (2017)

1 2 3 4 5 6 > >>