Vol. 63 No. 4 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 4 (2017)

DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-4-614-621

Published 01.04.2017

Igor Berlev⁺⁻
Yekaterina Nekrasova⁺⁻
Gayk Mkrtchyan⁺⁻
Yevgeniya Bezhanova⁺⁻
Katran Guseynov⁺⁻
Yelena Ulrikh⁺⁻
Viktoriya Bashlyk⁺⁻
Anna Artemeva⁺⁻
Tatyana Semiglazova⁺⁻
Aleksandra Kondakova⁺⁻
Andrey Mishchenko⁺⁻
Nikolay Mikaya⁺⁻
Adiliya Urmancheeva⁺⁻
Nikolay Bondarev⁺⁻
O. Smirnova⁺⁻

Igor Berlev

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Yekaterina Nekrasova

N.N. Petrov Research Institute of Oncology

Gayk Mkrtchyan

N.N. Petrov Research Institute of Oncology

Yevgeniya Bezhanova

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Katran Guseynov

N.N. Petrov Research Institute of Oncology

Yelena Ulrikh

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Viktoriya Bashlyk

N.N. Petrov Research Institute of Oncology

Anna Artemeva

N.N. Petrov Research Institute of Oncology

Tatyana Semiglazova

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Aleksandra Kondakova

N.N. Petrov Research Institute of Oncology

Andrey Mishchenko

N.N. Petrov Research Institute of Oncology

Nikolay Mikaya

N.N. Petrov Research Institute of Oncology

Adiliya Urmancheeva

N.N. Petrov Research Institute of Oncology, U. Mechnikov North-West State Medical University

Nikolay Bondarev

N.N. Petrov Research Institute of Oncology

O. Smirnova

N.N. Petrov Research Institute of Oncology

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Keywords

LOCALLY ADVANCED CERVICAL CANCER
DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY
PATHOMORPHOLOGICAL RESPONSE
YPCR
CR

How to Cite

Berlev, I., Nekrasova, Y., Mkrtchyan, G., Bezhanova, Y., Guseynov, K., Ulrikh, Y., Bashlyk, V., Artemeva, A., Semiglazova, T., Kondakova, A., Mishchenko, A., Mikaya, N., Urmancheeva, A., Bondarev, N., & Smirnova, O. (2017). DOSE-INTENSIVE NEOADJUVANT CHEMOTHERAPY IN COMBINED TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER: THE EXPERIENCE AND PERSPECTIVES. Voprosy Onkologii, 63(4), 614–621. https://doi.org/10.37469/0507-3758-2017-63-4-614-621

Abstract

In 24 patients (mean age 48 years) with locally advanced cervical cancer there were studied the efficacy and toxicity of 3 cycles of neoadjuvant dose-intensive chemotherapy with cisplatin (75 mg/m²) and doxorubicin (35 mg/m²) administered intravenously on the first day of a two- week cycle with the support of colony-stimulating factors. An important criterion for the inclusion in this study of patients with locally advanced cervical cancer (T1b2-2bN0-1M0) was the absence of infiltration of the anterior parameters according to the gynecological examination and MRI studies. An objective response to treatment was registered in 72.7 % of cases. Progression of the disease was not detected in any case. Conducting neoadjuvant drug therapy allowed performing radical surgical intervention in 95.4 % of patients. The pathomorphlogical response of tumor of varying severity was 40.9 %. In 9.1 % complete clinical regression of tumor was confirmed by a complete pathomor-phological response (CR). The dose-intensive regimen of chemotherapy did not lead to a significant increase of complications on the drug and surgical stages. An analysis showed that dose-intensive neoadjuvant chemotherapy is a highly effective method in treatment for locally advanced cervical cancer.

https://doi.org/10.37469/0507-3758-2017-63-4-614-621

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##article.numberofviews## 259

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