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The distribution of APOE 4 allele (rs 429358, C) was analyzed in healthy women (N=454) and patients with ovarian serous adenocarcinoma (N=114) in order to identify genetic predisposition to the disease. We determined the prognostic indicators of the E4 allele as a marker: odds ratio (OR) and AUC (Area Under Curve) - an area under the ROC curve. It was shown that APOE 4 allele was significantly associated with ovarian serous adenocarcinoma (p = 0,003; 0R=1,94; AUC=0,55). The Е4 genotypes frequency was significantly increased among patients (p = 0.02; 0R=1,8). Separate analysis of the two age subgroups (over 46 years and younger) found that the chance of developing ovarian serous adenocarcinoma was significantly increased for older women (p = 0,006; OR = 2,24, AUC = 0,76). Possible associations of APOE 4 with the ovarian serous adenocarcinoma in women of reproductive age deserve further studying.References
Иванова Т. И., Полуэктова Г. В., Хорохорина В. А. и др. Влияние генотипов APOE на биохимические показатели метаболизма железа и липидов у больных неопластическими заболеваниями эндометрия и здоровых женщин//Исследования и практика в медицине. -2014. -Т. 1 (1). -C. 35-44.
Иванова Т. И., Крикунова Л. И., Рябченко Н. И. и др. Способ определения риска развития рака тела матки. Патент РФ № 2558059, зарегистр. 10.07.2015.
Каприн А. Д., Старинский В. В. Злокачественные новообразования в России в 2014 году (заболеваемость и смертность). -Г.: ГНИОИ им. П.А. Герцена филиал ФГБУ «НГИРЦ» Гинздрава России, 2016. -250 с.
Козлов А. И., Боринская С. А., Санина Е. Д. «Экономный Генотип» £4/£4 по гену AРОЕ и риск метаболических нарушений в популяциях уральских народов//Экологическая генетика. -2011. -Т. 2 (9). -C. 17-23.
Соколенко А. П., Иевлева А. Г., Гитюшкина Н. В. и др. Синдром наследственного рака молочной железы и яичников в Российской Федерации//ACTA NATURAE. -2010. -Т. 2 (4). -C. 35-39.
Chen Y-C., Pohl G., Wang T.-L. et al. Apolipoprotein E is required for cell proliferation and survival in ovarian cancer//Cancer Research. -2005. -Vol. 1. -Р 331-337.
Corder E.H., Saunders A.M., Strittmatter W.J. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families//Science. -1993. -Vol. 5123. -P. 921-923.
Hough C.D., Sherman-Baust C.A., Pizer E.S. et al. Advances in brief large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer//Gynecologic Oncology. -2000. -Vol. 60. -P. 6281-6287.
Huvila J., Brandt A., Rojas C.R. et al. Gene expression profiling of endometrial adenocarcinomas reveals increased apolipoprotein E expression in poorly differentiated tumors//International Journal of Gynecological Cancer. -2009. -Vol. 19. -P. 1226-1231.
Ivanova T.I., Krikunova L.I., Ryabchenko N.I. et al. Association of the apolipoprotein E 2 allele with concurrent occurrence of endometrial hyperplasia and endometrial carcinoma//Oxidative Medicine and Cellular Longevity. -2015. -Vol. 2015. -P. e 593658.
Jofre-Monseny L., Minihane A.-M., Rimbach G. Impact of apoE genotype on oxidative stress, inflammation and disease risk//Molecular Nutrition & Food Research. -2008. -Vol. 52. -P. 131-145.
Kondrashova T.V., Neriishi K., Ban S. et al. Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers//Biochimica et Biophysica Acta -Molecular Basis of Disease. -2006. -Vol. 1762. -P 59-65.
Kuchenbaecker K.B., Ramus S.J., Tyrer J. et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer//Nat Genet. -2015. -Vol. 47 -P 164-171.
Kulminski A.M., Arbeev K.G., Culminskaya I. et al. Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the apolipoprotein E4 allele on lifespan//PLoS genetics. -2014. -Vol. 10. -P e10041411.
Nguyen D., Dhanasekaran P., Nickel M. et al. Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4//Biochemistry. -2010. -Vol. 49. -P. 10881-10889.
Porrata-Doria T., Matta J.L., Acevedo S.F. Apolipoprotein E allelic frequency altered in women with early-onset breast cancer//Breast cancer: Basic and clinical Research. -2010. -Vol. 4. -P 43-48.
Scarbrough P.M., Weber R.P, Iversen E.S. et al. A crosscancer genetic association analysis of the DNA repair and DNA damage signaling pathways for lung, ovary, prostate, breast and colorectal cancer//Cancer Epidemiol Biomarkers Prev. -2015. -Vol. 25. -P 193-200.
Slattery M.L., Swenney C., Murtaugh M. et al. Associations between apoE genotype and colon and rectal cancer//Carcinogenesis. -2005. -Vol. 26. -P. 1422-1429.
Surekha D., Vishnupriya S., Sailaja K. et al. Influence of apolipoprotein E gene polymorphism on the risk for breast cancer//International Journal of Human Genetics. -2008. -Vol. 8. -P. 277-282.
Trompet S., Jukema J.W., Katan M.B. et al. Apolipoprotein E genotype, plasma cholesterol, and cancer: a Mendelian randomization study//American Journal of Epidemiology. -2009. -Vol. 170. -P. 1415-1421.
Uchoa M.F., Moser V.A., Pike C.J. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors//Frontiers in Neuroendocrinology. 2016. (43). C. 60-82.
Watson M.A., Gay L., Stebbings W.S. et al. Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis//Clinical science. -2003. -Vol. 104. -P. 537-545.
Winham S.J., Pirie A., Chen YA. et al. Investigation of exomic variants associated with overall survival in ovarian cancer//Cancer Epidemiol Biomarkers Prev. -2016. -Vol. 25. -P. 446-454.
Zhou T.-B. Signaling pathways of prohibitin and its role in diseases//Journal of receptor and signal transduction research. -2013. -Vol. 33. -P 73-78.
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