Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

RADIATION BOOST AFTER WHOLE-BREAST IRRADIATION: DOSIMETRIC COMPARISON OF HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY AND IRRADIATION WITH ELECTRONS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-303-309

Published 01.03.2018

Sergey Kanaev⁺⁻
Ye. Bykova⁺⁻
I. Akulova⁺⁻
Nadezhda Popova⁺⁻
Pavel Krzhivitskiy⁺⁻
Petr Krivorotko⁺⁻
Olga Ponomareva⁺⁻
Zhanna Bryantseva⁺⁻
Sergey Novikov⁺⁻
Yu. Melnik⁺⁻

Sergey Kanaev

N.N. Petrov National Medical Research Center of Oncology

Ye. Bykova

N.N. Petrov National Medical Research Center of Oncology

I. Akulova

N.N. Petrov National Medical Research Center of Oncology

Nadezhda Popova

N.N. Petrov National Medical Research Center of Oncology

Pavel Krzhivitskiy

N.N. Petrov National Medical Research Center of Oncology

Petr Krivorotko

N.N. Petrov National Medical Research Center of Oncology

Olga Ponomareva

N.N. Petrov National Medical Research Center of Oncology

Zhanna Bryantseva

N.N. Petrov National Medical Research Center of Oncology

Sergey Novikov

N.N. Petrov National Medical Research Center of Oncology

Yu. Melnik

N.N. Petrov National Medical Research Center of Oncology

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Keywords

BREAST CANCER
RADIATION THERAPY

How to Cite

Kanaev, S., Bykova, Y., Akulova, I., Popova, N., Krzhivitskiy, P., Krivorotko, P., Ponomareva, O., Bryantseva, Z., Novikov, S., & Melnik, Y. (2018). RADIATION BOOST AFTER WHOLE-BREAST IRRADIATION: DOSIMETRIC COMPARISON OF HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY AND IRRADIATION WITH ELECTRONS. Voprosy Onkologii, 64(3), 303–309. https://doi.org/10.37469/0507-3758-2018-64-3-303-309

Abstract

Purpose: dosimetric comparison of high dose rate interstitial brachytherapy (HDR) and irradiation with electrons for radiation boost after whole-breast irradiation.

Material and methods: in 62 patients with рТ1N0М0-рТ2№М0 breast cancer we used HDR brachytherapy for delivering boost to tumor bed. In all cases insertion of plastic needles was performed under CT control with subsequent 3D planning. Pre-insertion CT were used for 3D planning of boost delivery with electrons.

Results: Boost delivery with HDR brachytherapy had several important advantages when compared with boost with electrons. HDR brachytherapy demonstrated more accurate irradiation of tumor bed: D90 HDR - 93,1 % (69,1 % - 118 %), D90 electrons - 86,2 % (47,6 % - 104,1 %). Boost delivery with HDR brachytherapy help to minimize radiation burden to left main coronary artery - Dmax electrons - 14.8 % (0.2 %-71.8%), Dmax HDR - 5.2 % (0.7 %-14.2 %). Radiation burden to left anterior descending artery is also decreasing: Dmax electrons - 21.9 % (0.8 %-94.1 %), Dmax HDR - 10.5 % (1.9 %-31.5 %). Radiation dose absorbed in ip-silateral lung also significantly lower with HDR brachytherapy: Dmed electrons - 6,5 % (0,5 % - 19,3 %), Dmed HDR - 2,3 % (0,8 % - 10,8 %).

Conclusions: the present dosimetric analysis indicated that boost delivery with HDR brachytherapy is more accurate than irradiation with electrons.

https://doi.org/10.37469/0507-3758-2018-64-3-303-309

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##article.numberofviews## 199

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RADIATION BOOST AFTER WHOLE-BREAST IRRADIATION: DOSIMETRIC COMPARISON OF HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY AND IRRADIATION WITH ELECTRONS

Keywords

How to Cite

Abstract

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