PREOPERATIVE SPECT-CT VISUALIZATION OF SENTINEL LYMPH NODES IN PATIENTS WITH CERVICAL CANCER: PRELIMINARY ANALYSIS OF THE DATA
##article.numberofdownloads## 46
##article.numberofviews## 160
PDF (Русский)

Keywords

CERVICAL CANCER
SENTINEL LYMPH NODES
SPECT-CT

How to Cite

Kanaev, S., Bisyarin, M., Krzhivitskiy, P., Berlev, I., Novikov, S., Melnik, Y., Mikaya, N., Kargopolova, M., & Mkrtchyan, G. (2019). PREOPERATIVE SPECT-CT VISUALIZATION OF SENTINEL LYMPH NODES IN PATIENTS WITH CERVICAL CANCER: PRELIMINARY ANALYSIS OF THE DATA. Voprosy Onkologii, 65(4), 524–531. https://doi.org/10.37469/0507-3758-2019-65-4-524-531

Abstract

Purpose: to determine preoperative SPECT-CT localization of sentinel lymph nodes (SLN) in women with cervical cancer.

Materials and methods: SPECT-CT visualization of SLN was performed in 44 women with clinical stage IB-IIB cervical cancer. SPECT-CT examinations started 120-240 min after peritumoural injections of 99mTc-radiocolloids (200-300MBq in 0.4-1ml). All visualized LNs with uptake of radiocolloids were regarded as SLN. In all women we determined topography of SLN and lymph-flow patterns.

Results: SLN were successfully visualized in 93.1% cases (41/44 women). The bilateral pattern of lymph flow was mentioned in 26 (63.4%), monolateral - in 15 (36.5%) cases. SLN localized in external iliac region in 25 (60.9%), internal iliac - in 14 (34.1%), obturator - in 22 (53.6%), presacral - in 1 (2.4%), common iliac region - in 21 (53,8%) cases. Uptake of radiocolloids in paraaortal lymph nodes was mentioned in 14 (34.1%) women

Conclusion: SPECT-CT visualization of SLN can give important information for surgery and radiotherapy planning.

https://doi.org/10.37469/0507-3758-2019-65-4-524-531
##article.numberofdownloads## 46
##article.numberofviews## 160
PDF (Русский)

References

Базаева И.Я, Горбунова В.А., Кравец О.А. и др. Химиолучевая терапия местно-распространенного рака шейки матки // Вопросы онкологии. - 2014. - Т 60. - № 2. - С. 280-287.

Канаев С.В., Новиков С.Н., Жукова Л.А. и др. Использование данных радионуклидной визуализации индивидуальных путей лимфооттока от новообразований молочной железы для планирования лучевой терапии // Вопросы онкологии. - 2011. - Т. 57. - № 5. - С. 616-621.

Канаев С.В., Новиков С.Н., Крживицкий П.И. и др. Применение ОФЭКТ-КТ для визуализации сигнальных лимфатических узлов и путей лимфооттока у больных раком языка // Вопросы онкологии. - 2019. - Т. 65. -№ 2. - С. 250-255.

Канаев С.В., Новиков С.Н. Роль радионуклидной визуализации путей лимфооттока при определении показаний к облучению парастернальных лимфоузлов // Вопросы онкологии. - 2015. - Т. 61. - № 5. - С. 737-744.

Каргополова М.В., Максимов С.Я., Берлев И.В. и др. Возможности и пределы современных методов диагностики отдаленных метастазов местнораспространенных форм рака шейки матки // Журнал акушерства и женских болезней. - 2013. - Т. LXII. - № 2. - С. 172-178.

Крживицкий П.И., Канаев С.В., Новиков С.Н., Ильин Н.Д., Новиков Р.В. Применение ОФЭКТ-КТ для визуализации сигнальных лимфатических узлов и путей лимфооттока у больных раком предстательной железы // Вопросы онкологии. - 2016. - Т 62. - № 2. - С. 272276.

Крживицкий П.И., Канаев С.В., Новиков С.Н. и др. Использование ОФЭКТ-КТ для визуализации сигнальных лимфатических узлов у больных раком молочной железы // Вопросы онкологии. - 2015. - Т. 61. - № 4. - С. 624-628.

Криворотько П.В., Канаев С.В., Семиглазов В.Ф. и др. Методологические проблемы биопсии сигнальных лимфатических узлов у больных раком молочной железы // Вопросы онкологии. - 2015. - Т. 61. - № 3. - С. 418-424.

Новиков С.Н., Канаев С.В., Каргаполова М.В. и др. Лучевая терапия рака шейки матки // «Рак шейки матки» под ред.И.В. Берлева, А.Ф. Урманчеевой. Эко-Вектор, 2018. -437. - С. 17/437.

Чернышова А.Л., Коломиец Л.А., Синилкин И.Г., Чернов В.И., Ляпунов А.Ю. Оптимизация подходов к выбору объема хирургического лечения у больных раком шейки матки (роль исследования сторожевых лимфоузлов) // Вопросы онкологии. - 2016. - Т. 62. - № 6. - С. 807-811.

Чернышова А.Л., Ляпунов А.Ю., Коломиец Л.А., Чернов В.И., Синилкин И.Г Определение сторожевых лимфатических узлов при хирургическом лечении рака шейки матки // Сибирский онкологический журнал. - 2012. - № 3. - С. 28-33.

Asiri M.A., Tunio M.A., Mohamed R., et al. Is extended-field concurrent chemoradiation an option for radiologic negative paraaortic lymph node, locally advanced cervical cancer? // Cancer Manag Res. - 2014. - Vol. 6. - P. 339-348.

Atri M, Zhang Z, Dehdashti F, et al. Utility of PET-CT to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: results of ACRIN6671/GOG0233 trial // Gynecol. Oncol. - 201. - Vol. 142(3). - P. 413-419.

Chantalat E., Vidal F, Leguevaque P. et al. Cervical cancer with paraaortic involvement: do patients truly benefit from tailored chemoradiation therapy? A retrospective study on 8 French centers // Eur. J. Obstet. Gynecol. Reprod. Biol. - 2015. - Vol. 193. - P. 118-122.

Cibula D., Potter R., Raspollini M.R. et al. Cervical cancer guidelines. - ESGO, 2018. http://www.sign.ac.uk/guide-lines/fulltext/50/annexoldb.html.

Diaz J.P., Gemignani M.L., Pandit-Taskar N. et al. Sentinel lymph node biopsy in the management of early-stage cervical carcinoma // Gynecol. Oncol. - 2011. - Vol. 120. - P. 347-352.

Gouy S., Morice P., Narducci F et al. Nodal-staging surgery for locally advanced cervical cancer in the era of PET // Lancet Oncol. - 2012. - Vol. 13(5). - P. 212-220.

Haie C., Pejovic M.H., Gerbaulet A. et al. Is prophylactic para-aortic irradiation worthwhile in the treatment of advanced cervical carcinoma? Results of a controlled clinical trial of the EORTC radiotherapy group // Radiother. Oncol. - 1988. - Vol. 11. - P. 101-112.

Hansen H.V., Loft A., Berthelsen A.K. et al. Survival outcomes in patients with cervical cancer after inclusion of PET/CT in staging procedures // Eur. J. Nucl. Med. Mol. Imaging. - 2015. - Vol. 42(12). - P. 1833-1837.

Hwang L., Bailey A., Lea J., Albuquerque K. Para-aortic nodal metastases in cervical cancer: a blind spot in the International Federation of Gynecology and Obstetrics staging system: current diagnosis and management // Future Oncol. - 2015. - Vol. 11(2). - P. 309-322.

Jiade J.Lu., Luther W.Brady., H.-P.Heilman., M.Molls., C. Nieder Decision making in radiation oncology. - Springer Press: New-York, 2011. - Vol.2. - P.661-701.

Jung J., Park G., Kim Y.S. Definitive extended-field intensity-modulated radiotherapy with chemotherapy for cervical cancer with para-aortic nodal metastasis // Anticancer Res. - 2014. - Vol. 34(8). - P. 4361-4366.

Kasuya G., Toita T., Furutani K. et al. Distribution patterns of metastatic pelvic lymph nodes assessed by CT/MRI in patients withuterine cervical cancer // Radiat. Oncol. -2013. - Vol. 8. - P. 139.

Laifer-Narin S.L., Genestine W.F., Okechukwu N.C. et al. The role of computed tomography and magnetic resonance imaging in gynecologic oncology // PET Clin. -2018. - Vol. 13(2). - P. 124-141.

Liang J.A., Chen S.W., Hung YC. et al. Low-dose, prophylactic, extended-field, intensity-modulated radiotherapy plus concurrent weekly cisplatin for patients with stage IB2-IIIB cervical cancer, positive pelvic lymph nodes, and negative para-aortic lymph nodes // Int. J. Gynecol. Cancer. - 2014. - Vol. 24. - P. 901-907.

Liu B., Gao S., Li S. A comprehensive comparison of CT, MRI, positron emission tomography or positron emission tomography/CT, and diffusion weighted imaging-MRI for detecting the lymph nodes metastases in patients with cervical cancer: a meta-analysis based on 67 studies // Gynecol. Obstet. Investig. - 2017. - Vol. 82(3). - P. 209-222.

Marnitz S., Kohler C., Bongardt S. et al. Topographic distribution of sentinel lymph nodes in patients with cervical cancer // Gynecol. Oncol. - 2006. - Vol. 103. - P. 35-44.

Potter R, Georg P., Dimopoulos J.C.A. et al. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer // Radiotherapy and Oncology. -2011. - Vol. 100. - Issue 1. - P 116-123.

Ptter R., Tanderup K., Kirisits C. et al. The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies // Clinical and Translational Radiation Oncology. - 2018. - Vol. 9. - P. 48-60.

Rotman M., Choi K., Guse C. et al. Prophylactic irradiation of the para-aortic lymph node chain in stage IIB and bulky stage IB carcinoma of the cervix, initial treatment results of RTOG7920 // Int. J. Radiat. Oncol. Biol. Phys. - 1990. - Vol. 19. - P 513-521.

Rotman M., Sedlis A., Piedmonte M.R. et al. A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features: follow-up of a gynecologic oncology group study // Int. J. Radiat. Oncol. Biol. Phys. - 2006. - Vol. 65. - P 169-176.

Salvo G., Ramirez PT, Levenback C.F. et al. Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer // Gynecol. Oncol. - 2017. - Vol. 145. - P 96-101.

Sapienza L.G., Gomes M.J.L., Calsavara V.F. et al. Does para-aortic irradiation reduce the risk of distant metastasis in advanced cervical cancer? A systematic review and meta-analysis of randomized clinical trials // Gynecol. Oncol. - 2017. - Vol. 144(2). - P 312-317.

Sedlis A., Bundy B.N., Rotman M.Z. et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study // Gynecol. Oncol. - 1999. - Vol. 73. - P 177-183.

Small W. Jr, Mell L.K., Anderson P et al. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer // Int. J. Radiat. Oncol. Biol. Phys. - 2008. - Vol. 71. - P 428-434.

Vandeperre A., Van Limbergen E., Leunen K. et al. Paraaortic lymph node metastases in locally advanced cervical cancer: comparison between surgical staging and imaging // Gynecol. Oncol. - 2015. - Vol. 138(2). - P 299-303.

Yap M.L., Cuartero J., Yan J. et al. The role of elective para-aortic lymph node irradiation in patients with locally advanced cervical cancer // Clin. Oncol. (R Coll Radiol). - 2014. - Vol. 26(12). - P 797-803.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© АННМО «Вопросы онкологии», Copyright (c) 2019