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摘要
Первичные опухоли могут метастазировать почти во все ткани организма, но некоторые опухоли, такие как рак молочной железы, рак предстательной железы, рак легких, рак щитовидной железы и рак почки преимущественно метастазируют в кости. Кость является третьей по частоте локализации метастазирования после легких и печени. Клинические проявления костных метастазов включают боль, снижение подвижности, патологические переломы и т. д., которые в совокупности называются событиями, связанными со скелетом (skeletal-related events, SREs). Появление метастазов в кости ухудшает качество жизни пациентов и сокращают период выживаемости. В настоящее время, механизм метастазирования опухолевых клеток в кости не полностью ясен. Последние исследования показывают, что возникновение вторичных изменений в скелете связано с характеристикой опухолевых клеток, костным микроокружением и взаимодействием между ними. В данном литературном обзоре проведён анализ различных видов метастазов в кости, характеристик опухолевых клеток, специфичности костного микроокружения и взаимодействие между ними, что может обеспечить теоретическую основу для поиска новых подходов в профилактике и лечении костных метастазов. Для подготовки обзора проведен поиск литературы по базам данных Scopus, Web of Science, Medline, PubMed, CyberLeninka, РИНЦ и CNKI. При анализе использованы источники, индексируемые в базах данных Scopus и Web of Science (93%), РИНЦ и CNKI (7%). Более 50% работ опубликовано за последние 5 лет. Использовано 83 источника для написания данного литературного обзора.
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