Ключевые слова
Как цитировать
Аннотация
Прогресс в лекарственном лечении сарком невероятно медленный: в первую очередь ему препятствует часто развивающаяся устойчивость опухолей к стандартной химиотерапии препаратами в максимально переносимых дозах. Клональная эволюция опухолевых клеток порождает их высокую генетическую гетерогенность, лежащую в основе устойчивости к химио- и лучевой терапии. Следствием такой химиорезистентности является местное распространение и диссеминация процесса, что, в свою очередь, существенно снижает качество жизни пациента и повышает вероятность неблагоприятного исхода заболевания. Цель данной статьи - осветить современные представления о клональной эволюции опухолевых клеток и влияние этого процесса на перспективы терапии пациентов с саркомами.
Библиографические ссылки
Bui N.Q., Wang D.S., Hiniker S.M. Contemporary management of metastatic soft tissue sarcoma // Curr Probl Cancer. - 2019. - DOI: 10.1016/j.currproblcancer.2019.06.005
McGranahan N., Swanton C. Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future // Cell. - 2017. - Vol. 168(4). - P. 613-628. - 10.1016/j. Cell.2017.01.018. DOI: 10.1016/j.cell.2017.01.018
Nowell P.C. The clonal evolution of tumor cell populations // Science. - 1976. - Vol. 194(4260). - P. 23-28. - DOI: 10.1126/science.959840
Kreso A., Dick J.E. Evolution of the cancer stem cell model // Cell Stem Cell. - 2014. - Vol. 14(3). - P. 275-291. - DOI: 10.1016/j.stem.2014.02.006
Ellsworth D.L., Blackburn H.L., Shriver C.D. et al. Single-cell sequencing and tumorigenesis: improved understanding of tumor evolutionand metastasis // Clin. Transl. Med. - 2017. - Vol. 6(1). - P. 15. - DOI: 10.1186/s40169-017-0145-6
Yates L.R., Gerstung M., Knappskog S. et al. Subclonal diversification of primary breast cancer revealed by multiregion sequencing // Nat Med. - 2015. - Vol. 21. - P. 751-759. - DOI: 10.1038/nm.3886
Boutros P.C., Fraser M., Harding N.J. et al. Spatial genomic heterogeneity within localized, multifocal prostate cancer // Nat Genet. - 2015. - Vol. 47. - P. 736-745. - DOI: 10.1038/ng.3315
Harbst K., Lauss M., Cirenajwis H. et al. Multiregion whole-exome sequencing uncovers the genetic evolution and mutational heterogeneity of early-stage metastatic melanoma // Cancer Res. - 2016. - Vol. 76. - P. 4765-4774. - DOI: 10.1158/0008-5472
Kang H., Salomon M.P., Sottoriva A. et al. Many private mutations originate from the first few divisions of a human colorectal adenoma // J Pathol. - 2015. - Vol. 237. - P. 355-362. - DOI: 10.1002/path.4581
Yachida S., Jones S., Bozic I. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer // Nature. - 2010. - Vol. 467. - P. 1114-1117. - DOI: 10.1038/nature09515
Li Y., Xu X., Song L. et al. Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer // GigaScience. - 2012. - Vol. 1. - P. 12. - DOI: 10.1186/2047-217X-1-12
Zhang J., Fujimoto J., Zhang J. et al. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing // Science. - 2014. - Vol. 346. - P. 256-259. - DOI: 10.1126/science.1256930
Alexandrov L.B., Nik-Zainal S., Wedge D.C. et al. SigNatures of mutational processes in human cancer // Nature. - 2013. - Vol. 500(7463). - P. 415-421. - DOI: 10.1038/nature12477
Davis A., Gao R., Navin N. Tumor evolution: Linear, branching, neutral or punctuated? // Biochimica et biophysica acta. Reviews on cancer. - 2017. - Vol. 1867(2). - P. 151-161. - DOI: 10.1016/j.bbcan.2017.01.003
McPherson A., Roth A., Laks E. et al. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer // Nat Genet. - 2016. - Vol. 48(7). - P. 758-767. - DOI: 10.1038/ng.3573
Gerlinger M., Horswell S., Larkin J. et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing // Nat Genet. - 2014. - Vol. 46. - P. 225-233. - DOI: 10.1038/ng.2891
Baumhoer D. The clonal evolution of osteosarcomas // Pathologe. - 2016. - Vol. 37(Suppl 2). - P. 163-168. - DOI: 10.1007/s00292-016-0200-x
Hofvander J., Viklund B., Isaksson A. et al. Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years // Nature communications. - 2018. - Vol. 9(1). - P. 3662. - DOI: 10.1038/s41467-018-06098-0
Shah S.P., Roth A., Goya R. et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers // Nature. - 2012. - Vol. 486(7403). - P 395-359. - DOI: 10.1038/nature10933
Beird H.C., Wu C.C., Ingram D.R. et al. Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin // Cold Spring Harb Mol Case Stud. - 2018. - Vol. 4(2). - DOI: 10.1101/mcs.a002386
Williams M.J., Werner B., Barnes C.P., Graham T.A., Sottoriva A. Identification of neutral tumor evolution across cancer types // Nat Genet. - 2016. - Vol. 48(3). - P. 238-244. - DOI: 10.1038/ng.3489
Sottoriva A., Kang H., Ma Z. et al. Bang model of human colorectal tumor growth // Nat Genet. - 2015. - Vol. 47. - P. 209-216. - DOI: 10.1038/ng.3214
Zhang C.Z., Spektor A., Cornils H. et al. Chromothripsis from DNA damage in micronuclei // Nature. - 2015. - Vol. 522(7555). - P. 179-184. - DOI: 10.1038/na-ture14493
Wang Y, Waters J., Leung M.L. et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing // Nature. - 2014. - Vol. 512 - P. 155-160. - DOI: 10.1038/nature13600
Saito T., Niida A., Uchi R. et al. A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer // Nature Communications. - 2018. - Vol. 9(1). - P. 2884. - DOI: 10.1038/s41467-018-05226-0
Walther C., Mayrhofer M., Nilsson J. et al. Genetic heterogeneity in rhabdomyosarcoma revealed by SNP array analysis // Genes Chromosomes Cancer. - 2016. - Vol. 55(1). - P 3-15. - DOI: 10.1002/gcc.22285
Abeshouse A., Adebamowo C., Adebamowo S. et al. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas // Cell. - 2017. - Vol. 171. P. 950-965. - DOI: 10.1016/j.cell.2017.10.014
Perry J.A., Kiezun A., Tonzi P. et.al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma // Proc Natl Acad Sci USA. - 2014. - Vol. 111(51). - E. 5564-5573. - DOI: 10.1073/pnas.1419260111
Martin J.W., Chilton-MacNeill S., Koti M. et al. Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma // PLoS ONE. - 2014. - Vol. 9(5). - E95843. - DOI: 10.1371/journal.pone.0095843
Kovac M., Blattmann C., Ribi S. et al. Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency // Nat Commun. - 2015. - Vol. 6. - P 8940. - DOI: 10.1038/ncomms9940
Rye I.H., Trinh A., Saetersdal A.B. et al. Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors // Mol Oncol. - 2018. - Vol. 12(11). - P. 1838-1855. - DOI: 10.1002/1878-0261.12375
Kandoth C., McLellan M.D., Vandin F. et al. Mutational landscape and significance across 12 major cancer types // Nature. - 2013. - Vol. 502. - P. 333-339. - DOI: 10.1038/nature12634
Gay L., Baker A.M., Graham T.A. Tumour Cell Heterogeneity. // F1000Research. - 2016. - Vol. 5. - F1000 Faculty Rev-238. - DOI: 10.12688/f1000research.7210.1
Lee M.C., Lopez-Diaz F.J., Khan S.Y et al. Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing // Proc Natl Acad Sci USA. - 2014. - Vol. 111(44). - E. 4726-4735. - DOI: 10.1073/pnas.1404656111
Phipps A.I., Limburg P.J., Baron J.A. et al. Association between molecular subtypes of colorectal cancer and patient survival // Gastroenterology. - 2015. - Vol. 148(1). - P 77-87. - DOI: 10.1053/j.gastro.2014.09.038
Allison K.H., Sledge G.W. Heterogeneity and cancer // Oncology (Williston Park). -2014. - Vol. 28. - P 772-778.
Stanta G., Bonin S. Overview on Clinical Relevance of Intra-Tumor Heterogeneity // Frontiers in medicine. - 2018. - Vol. 5. - P. 85. - DOI: 10.3389/fmed.2018.00085
Lawrence M.S., Stojanov P., Polak P. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes // Nature. - 2013. - Vol. 499(7457). - P. 214-218. - DOI: 10.1038/nature12213
Landau D.A., Carter S.L., Stojanov P et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia // Cell. - 2013. - Vol. 152(4). - P 714-726. - DOI: 10.1016/j.cell.2013.01.019
Enriquez-Navas P.M., Wojtkowiak J.W., Gatenby R.A. Application of evolutionary principles to cancer therapy // Cancer Res. - 2015. - Vol. 75(22). - P. 4675-4680. - DOI: 10.1158/0008-5472.CAN-15-1337
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