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Abstract
The progress in drug treatment of sarcomas is incredibly slow: primary, it is hindered by often developing resistance of tumors to standard chemotherapy with drugs in the maximum tolerated dosages. The clonal evolution of the tumor mass generates a high genetic heterogeneity of cancer cells, which underlies resistance to chemo- and radiotherapy. The consequence of such chemoresistance is local distribution and dissemination of the process, which, in turn, significantly reduces the quality of life of the patient and increases the probability of an adverse outcome of the disease. The purpose of this article is to highlight the modern understanding of the clonal evolution of tumor cells and the effect of this process on the clinical prospects of cancer patients.References
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