Vol. 66 No. 4 (2020), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 66 No. 4 (2020)

COMBINED DIAGNOSTICS OF LUNG CANCER USING EXHALED BREATH ANALSYSIS AND SPUTUM CYTOLOGY

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2020-66-4-381-384

Published 01.04.2020

A. Arseniev⁺⁻
A. Nefedova⁺⁻
A. Ganeeva⁺⁻
A. Nefedov⁺⁻
S. Novikov⁺⁻
Anton Barchuk⁺⁻
S. Kanaev⁺⁻
I. Jahatspanian⁺⁻
A. Gubal⁺⁻
A. Kononov⁺⁻
S. Tarkov⁺⁻
N. Aristidov⁺⁻

A. Arseniev

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Nefedova

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Ganeeva

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Nefedov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Novikov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

Anton Barchuk

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Kanaev

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

I. Jahatspanian

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Gubal

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Kononov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Tarkov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

N. Aristidov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

##article.numberofdownloads## 42

##article.numberofviews## 227

PDF (Русский)

Keywords

SCREENING
LUNG CANCER
GAS ANALYZER
EXHALED BREATH
SPUTUM CYTOLOGY

How to Cite

Arseniev, A., Nefedova, A., Ganeeva, A., Nefedov, A., Novikov, S., Barchuk, A., Kanaev, S., Jahatspanian, I., Gubal, A., Kononov, A., Tarkov, S., & Aristidov, N. (2020). COMBINED DIAGNOSTICS OF LUNG CANCER USING EXHALED BREATH ANALSYSIS AND SPUTUM CYTOLOGY. Voprosy Onkologii, 66(4), 381–384. https://doi.org/10.37469/0507-3758-2020-66-4-381-384

Abstract

In this article we summarize our own experience of lung cancer diagnostics using exhaled breath analysis with a non-selective method using metal oxide chemoresistor gas sensors with cross-sensitivity combined with the sputum cytology. Volatile organic compounds of exhaled breath change the conductivity of the sensor, the resulting pulse is displayed as a peak on the graph, the area of which is used as test results. The combination of two diagnostic techniques in 204 participants demonstrated the possibility of non-invasively detecting the disease at an early stage. The sensitivity, specificity and accuracy of the breath analysis was 91.2%, 100% and 93.4%, respectively. The combination of the breath test and the sputum cytology compared to the breath test alone showed statistically significant (p = 0.03) increase in sensitivity to 96.8% (95% CI: 80.9% -99%) with acceptable decrease in specificity to 93.4% (95% CI: 88% -96%). The convenience of analysis and realtime measurements show some promise for the early detection.

https://doi.org/10.37469/0507-3758-2020-66-4-381-384

##article.numberofdownloads## 42

##article.numberofviews## 227

PDF (Русский)

References

Барчук А.А., Арсеньев А.И., Левченко Е.В. и др. Автоматизированная количественная цитометрия в диагностике рака лёгкого // Вопросы онкологии. - 2011. - Т. 57. - № 1. - С. 36-42.

Мерабишвили В.М. Онкологическая служба в Санкт-Петербурге и районах города (заболеваемость, смертность, выживаемость) / Ежегодник Популяционного ракового регистра. - СПб.: ИПК Коста, 2017. - 240 с.

Nakhleh M.K., Amal H., Jeries R. Diagnosis and Classification of 17 Diseases from 1404 Subjectsvia Pattern Analysis of Exhaled Molecules // ACS Nano. - 2017. - Vol. 11(1). - P. 112-125.

Nardi-Agmon I., Abud-Hawa M., Liran O. et al. Exhaled Breath Analysis for Monitoring Response to Treatment in Advanced Lung Cancer // J. Thorac. Oncol. - 2016. - Vol. 11. - Р. 827-837.

Wu G., Wang E., Li J. Clinical value of liquid-based cytologic test in sputum examination of patients with lung cancer // ZhongguoFei Ai ZaZhi - 2006. - Vol. 9(2). - Р. 192-195.

Wu G.X., Raz D.J. Lung Cancer Screening // Cancer Treat. Res. - 2016. - Vol. 170. - Р. 1-23.

Zhang Y, Gao G., Liu H. et al. Identification of Volatile Biomarkers of Gastric Cancer Cells and Ultrasensitive Electrochemical Detection Based on Sensing Interface of Au-Ag Alloy Coated MWCNTs // Theranostics. - 2014. - Vol. 4. - Р. 154-162.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

Andrey Arsenev, Sergey Novikov, Aleksey Barchuk, Sergey Kanaev, Anton Barchuk, S. Tarkov, Andrey Nefedov, K. Kostitsyn, K. Gagua, A. Nefedova, Nikolay Aristidov, LUNG CANCER DIAGNOSIS: NON-INVASIVE AND INVASIVE METHODS , Voprosy onkologii : Vol. 66 No. 1 (2020)
Ivan Stilidi, Sergey Nered, Aleksey Kalinin, Olesya Rossomakhina, Anton Barchuk, EFFICIENCY OF ADJUVANT XELOX CHEMOTHERAPY FOR PATIENTS WITH RESECTABLE GASTRIC IN RUSSIA (SINGLE INSTITUTION RETROSPECTIVE STUDY) , Voprosy onkologii : Vol. 65 No. 2 (2019)
Vladimir Semiglazov, E. Zhiltsova, Petr Krivorotko, S. Kanaev, E. Trufanova, P. Krzhivitskiy, Aleksandr Komyakhov, T. Tabagua, K. Nikolaev, A. Bessonov, V. Ivanov, Larisa Gigolaeva, O. Ivanova, K. Zernov, G. Dashyan, R. Paltuev, V. Semiglazov, A. Emelyanov, E. Busko, A. Chernaya, A. Artemyeva, S. Nonikov, EXPERIENCE OF SENTINEL LYMPH NODE BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY , Voprosy onkologii : Vol. 66 No. 4 (2020)
Vakhtang Merabishvili, Iuliia Iurkova, Aleksandr Shcherbakov, Evgenii Levchenko, Anton Barchuk, Nikolai Krotov, Elvira Merabishvili, Lung cancer (C33, 34). Morbidity, mortality, accuracy of registration, localization and histological structure (population study) , Voprosy onkologii : Vol. 67 No. 3 (2021)
Аndrey Аrseniev , Sergey Novikov, Sergey Kanaev, Evgeny Arsenyev, Sergey Tarkov , Anton Barchuk , Yuliya Melnik, Andrey Nefedov , Roman Novikov, Anton Zozulya , Ketevan Gagua , Nikolay Aristidov , Filipp Antipov , Yuri Merezhko , Nikolay Ilyin , Vascular mechanisms in the radiobiological effects from high-dose radiotherapy (literature review) , Voprosy onkologii : Vol. 69 No. 2 (2023)
Andrey Arsenyev , Sergey Kanaev , Evgeny Arsenyev, Sergey Tarkov , Anton Barchuk , Yulia Melnik, Andrey Nefedov, Roman Novikov , Ketevan Gagua , Nikolay Aristidov , Nikolay Ilyin , Philip Antipov , Yuri Merezhko , Anton Zozulya , Sergey Novikov , Linear-quadratic model in the description of the mechanisms of high-dose radiation therapy , Voprosy onkologii : Vol. 68 No. 6 (2022)
Аndrey Аrseniev , Andrey Nefedov , Sergey Novikov , Anton Barchuk , Sergey Tarkov , Sergey Kanaev , Kirill Kostitsyn , Alina Nefedova , Ketevan Gagua , Nikolay Aristidov , Surgical management options in lung cancer with malignant pleural disease , Voprosy onkologii : Vol. 68 No. 2 (2022)
Anton Barchuk, A. Atroshchenko, V. Gaydukov, P. Vinogradov, Sergey Tarakanov, Sergey Kanaev, Andrey Arsenev, Yuriy Komarov, Mikhail Kharitonov, Aleksey Barchuk, Vakhtang Merabishvili, Vladimir Kuznetsov, Vladimir Trofimov, Nataliya Gusarova, Igor Kotsyuba, Aleksey Belyaev, Maksim Podolskiy, A. Nefedova, AUTOMATED DIAGNOSIS IN A POPULATION-BASED SCREENING FOR LUNG CANCER , Voprosy onkologii : Vol. 63 No. 2 (2017)
Andrey Arseniev , Sergey Novikov, Sergey Kanaev , Evgeny Arseniev, Sergey Tarkov, Anton Barchuk, Yulia Melnik, Andrey Nefedov, Roman Novikov, Anton Zozulya, Nikolay Aristidov, Filipp Antipov, Yuriy Merezhko, Nikolay Ilyin, Zhanna Bryantseva, Irina Akulova , The Non-Targeted Abscopal Effect in High Dose-Rate Radiobiology , Voprosy onkologii : Vol. 69 No. 4 (2023)
Anton Barchuk, K. Gagua, S. Tarkov, A. Nefedova, Andrey Nefedov, Aleksandr Shcherbakov, Aleksey Barchuk, Sergey Kanaev, Viktor Gombolevskiy, Aleksey Belyaev, Andrey Arsenev, K. Kostitsyn, THE EFFECTIVENESS OF SCREENING FOR CANCER , Voprosy onkologii : Vol. 63 No. 4 (2017)

1 2 3 > >>