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Abstract
The important role of the thyroid axis in the body's response to various endogenous and exogenous factors is beyond doubt. The data on the effect of tumor growth on the functional activity of the thyroid gland are inconsistent. A modifying effect of chronic neurogenic pain on the biological aggressiveness of transplantable B16/F10 melanoma requires studying the main mechanisms of action. The aim of the study was to analyze the effect of chronic neurogenic pain on the functional activity of the thyroid gland in the dynamics of B16/F10 melanoma growth in male mice. Methods. The comparison group included animals with standard subcutaneous transplantation of B16/F10 melanoma; the main group - mice with B16/F10 melanoma transplanted 2 weeks after the generation of the chronic neurogenic pain model. Levels of total and free forms of thyroid hormones and TSH were determined in thyroid cytosolic fractions by standard ELISA methods. Results. Chronic neurogenic pain increases the levels of free forms of thyroid hormones and total triiodothyronine, but decreases the levels of TSH and total thyroxin in the thyroid, as well as the organ weight coefficient in male mice with transplanted B16/F10 melanoma. Conclusions. The results demonstrated that the thyroid activity was a point of application of modifying influence of chronic neurogenic pain on the course of transplantable B16/F10 melanoma in male mice.
References
Решетняк Д.В., Смирнова В.С., Кукушкин М.Л. Половые различия при изменении биохимических показателей крови у крыс в ответ на острую соматическую и хроническую нейрогенную боль. Боль. 2004,2(3):12-16.
Кукушкин М.Л. Этиопатогенетические принципы лечения хронической боли. Русский медицинский журнал. 2007,15(10):827.
Hoermann R., Midgley J.E., Larisch R., Dietrich J.W. Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment. Front Endocrinol. 2015,6. doi. 177.. DOI: 10.3389/fendo.2015
Da Costa Mario Augusto Cray, Trentini Conrado Auer, Shafranski Marcelo Derbli, Pipino Osvaldo, Gomez Ricardo Zanetti, dos Santos Reis Eliza Souza. Factors associated with the development of chronic pain after a stentotomy: a study using random control. Braz J. Cardiovasc Surg. 2015,30(5):552-556. DOI: 10.5935/1678-9741.20150059
Goede S.L., Leow M.K., Smit J.W. et al. Hypothalamuspituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges. Bull Math Biol. 2014,76(6):1270-1287. DOI: 10.1007/s11538-014-9955-5
Hoermann R., Larisch R., Dietrich J.W., Midgley J.E. Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method. Eur J Endocrinol. 2016,174(6):735-743. DOI: 10.1530/EJE-16-0031
Кит О.И., Франциянц Е.М., Бандовкина В.А., Черярина н.д. Половые различия функционирования щитовидной железы в динамике роста перевивной меланомы B16/F10 у мышей. Российский онкологический журнал. 2016,21(5):253-258.
Франциянц Е.М., Бандовкина В.А., Каплиева И.В. и др. Влияние роста перевивной меланомы В16-10 на функционирование гипоталамо-гипофизарно-надпочечниковой и тиреоидной осей организма у самцов и самок мышей. Известия высших учебных заведений. Северо-Кавказский регион. Серия: Естественные науки. 2017,3-2(195-2):118-124.
Lin H.Y, Chin Y.T., Yang Y.C. et al. Thyroid Hormone, Cancer, and Apoptosis. Compr Physiol. 2016,6(3):1221-1237. DOI: 10.1002/cphy.c150035
Козлова М.Б., Франциянц Е.М., Владимирова Л.Ю. и др. Тиреоидный и глюкокортикоидный статус у больных со злокачественной и доброкачественной патологией молочных желез. Сибирский онкологический журнал. 2009,4:52-56.
Aloisi A.M., Water S., Buonocore M. Pain and thyroid hormones. Neurol Sci. 2013,34(9):1501-1508. 10.1007 / s10072-013-1440-7. DOI: 10.1007/s10072-013-1440-7
Tsatsoulis A. The role of stress in the clinical expression of thyroid autoimmunity. Ann N Y Acad Sci. 2006,1088:382395. DOI: 10.1196/annals.1366.015
Chrousos G.P. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009,5(7):374-381. DOI: 10.1038/nrendo.2009.106
Fabian I.D., Rosner M., Fabian I. et al. Low thyroid hormone levels improve survival in murine model for ocular melanoma. Oncotarget. 2015,6(13):11038-11046.
Глушаков Р.И., Козырко Е.В., Соболев И.В. и др. Заболевания щитовидной железы и риск возникновения нетиреоидной патологии. Казанский медицинский журнал. 2017,98(1):77-84
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