Experimental therapy for rabbits with radiation cystitis

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2021-67-1-150-156

Published 03.03.2022

Oleg Korytov
Sergey Ivanov
Luiza Korytova
Alexandr Semenov
Grigory Tochilnikov
Irina Vasilyeva
Vladimir Bespalov
Artur Achtemzyanov

Oleg Korytov

Sergey Ivanov

Luiza Korytova

Alexandr Semenov

Grigory Tochilnikov

Irina Vasilyeva

Vladimir Bespalov

Artur Achtemzyanov

pdf (Русский)

Keywords

bladder
radiation cystitis
AGDL gel
intravesical administration

How to Cite

Korytov, O., Ivanov, S., Korytova, L., Semenov, A., Tochilnikov, G., Vasilyeva, I., Bespalov, V., & Achtemzyanov, A. (2022). Experimental therapy for rabbits with radiation cystitis. Voprosy Onkologii, 67(1), 150–156. https://doi.org/10.37469/0507-3758-2021-67-1-150-156

Abstract

Using a new model of the induction of radiation cystitis (RC) in rabbits, the treatment effectiveness of animals with intravesical administration of a biodegradable drug - a gel containing salts of alginic and hyaluronic acids, as well as dioxidine and lidocaine (AHDL) was assessed. The work was performed on female rabbits of the “Chinchilla” breed. Fractional irradiation of the rabbit urinary bladder was carried out by a linear photon accelerator: a single dose per fraction was 6 Gy administered daily for 5 days to a total focal dose of 30 Gy. As a result of irradiation of the bladder, the animals developed RC. AHDL-gel was injected intravesically using a catheter at a dose of 2500 mg / kg of body weight 3 times a day weekly for 2 months, starting from 1 month after irradiation. The drug had a pronounced therapeutic effect on the rabbits with RC: the values of clinical and laboratory indicators of cystitis in urea and blood were reduced, it was observed regression of morphological manifestations of inflammation in the bladder mucosa.

https://doi.org/10.37469/0507-3758-2021-67-1-150-156

pdf (Русский)

References

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