The combination of late radiation injuries of the pelvic organs in a patient after chemoradiotherapy of cervical cancer II b (cT2bN0M0) and their treatment (clinical example)

CLINICAL CASES

https://doi.org/10.37469/0507-3758-2022-68-1-99-105

Published 28.02.2022

Inna Sycheva
Andrey Kaprin
Sergey Ivanov

Inna Sycheva

Andrey Kaprin

Sergey Ivanov

pdf (Русский)

Keywords

cervical cancer
chemoradiotherapy
radiation injuries
vaginal radiation epithelitis (ulceration of the vagina)
radiation cystitis
radiation rectitis (radiation proctitis)

How to Cite

Sycheva, I., Kaprin, A., & Ivanov, S. (2022). The combination of late radiation injuries of the pelvic organs in a patient after chemoradiotherapy of cervical cancer II b (cT2bN0M0) and their treatment (clinical example). Voprosy Onkologii, 68(1), 99–105. https://doi.org/10.37469/0507-3758-2022-68-1-99-105

Abstract

A clinical case of successful conservative treatment of radiation injuries (RI) of the pelvic organs (late radiation ulcerative-necrotic epithelitis of the vagina – ulceration of the vagina, late radiation ulcerative-necrotic cystitis and late radiation hemorrhagic rectitis) after CRT cervical cancer IIB art. (cT2bN0M0) is presented. There are still no standards for the treatment of RI either in our country or abroad. After treatment, the patient is observed in our department for 5 years (every six months) without relapses and progression of the main oncological disease and exacerbations of radiation injuries. This pathology is an important object for study. In the absence of the effectiveness of conservative treatment, endoscopic or subsequent surgical intervention is indicated. Keywords: cervical cancer; chemoradiotherapy; radiation injuries; vaginal radiation epithelitis (ulceration of the vagina); radiation cystitis; radiation rectitis (radiation proctitis).

https://doi.org/10.37469/0507-3758-2022-68-1-99-105

pdf (Русский)

References

Столярова И.В., Винокуров В.А. Проблемы больных после лечения рака шейки матки (профилактика и лечение постлучевых осложнений) // Практическая онкология. 2002;3(3):220–227 [Stolyarova IV, Vinokurov VA. Problems of patients after treatment of cervical cancer (prevention and treatment of post-radiation complications) // Prakticheskaya onkologiya. 2002;3(3):220–227 (In Russ.)].

Дунаева Е.А., Бойко А.В., Демидова Л.В. и др. Консервативные методы профилактики и лечения лучевых повреждений у больных злокачественными новообразованиями женских половых органов // Медицинская радиология и радиационная безопасность. 2015;60(5):59–73 [Dunaeva EA, Boyko AV, Demidova LV et al. Conservative methods of prevention and treatment of radiation complications in patients with malignant neoplasms of female genital organs // Meditsinskaya radiologiya i radiatsionnaya bezopasnost'. 2015;60(5):59–73 (In Russ.)].

Шейко Е.А., Родионова О.Г., Шихлярова А.И. и др. Квантовая медицина при лечении лучевых поражений органов малого таза (обзор литературы) // Международный журнал прикладных и фундаментальных исследований. 2016(8–4):542–549 [Sheiko EA, Rodionova OG, Shikhlyarova AI et al. Quantum medicine in the treatment of radiation lesions of the pelvic organs (literature review) // Mezhdunarodnyi zhurnal prikladnykh i fundamental'nykh issledovanii. 2016(8–4):542–549 (In Russ.)].

Пасов В.В., Курпешева А.К., Терехов О.В. Местные лучевые повреждения у онкологических больных (консервативное лечение) // Терапевтическая радиология / Под ред. Цыба А.Ф., Мардынского Ю.С. М.: Медицинская книга, 2010. Гл. 15:505–550 [Pasov VV, Kurpesheva AK, Terekhov OV. Local radiation injuries in cancer patients (conservative treatment). Therapeutic radiology / Ed by Tsyb AF, Mardynsky YuS. M.: Meditsinskaya kniga, 2010. Chapter 15:505–550. (In Russ.)].

Паньшин Г.А., Рыбаков Ю.Н., Близнюков О.П., Зотов В.К. К вопросу о местных лучевых повреждениях прямой кишки у больных раком шейки матки (обзор) // Вестник Российского научного центра рентгенорадиологии. 2010;2(10):5 [Panshin GA, Rybakov YuN, Bliznyukov OP, Zotov VK. On the question of local radiation injuries of the rectum in patients with cervical cancer (overview) // Vestnik Rossiiskogo nauchnogo tsentra rentgenoradiologii. 2010;2(10):5 (In Russ.)].

Семирджанянц Э.Г., Петровский А.В., Фанштейн И.А. и др. Хирургическая реабилитация больных с постлучевыми ректо-вагинальными свищами при раке шейке матки // Колопроктология. 2013;46(4):13–17 [Semirdzhanjantc JeG, Petrovskij AV, Fanshtein IA et al. Surgical correction of rectovaginal fistulas caused by radiotherapy for cervical cancer // Koloproktologiya. 2013;46(4):13–17 (In Russ.)].

Сычева И.В. Лечение лучевых повреждений органов малого таза после лучевой терапии рака предстательной железы // Сибирский онкологический журнал. 2018;17(3):64–71. doi:10.21294/1814-4861-2018-17-3-64-71 [Sycheva IV. Treatment of radiation-induced pelvic damage after radiation therapy for prostate cancer // Sibirskii onkologicheskii zhurnal. 2018;17(3):64–71 (In Russ.)]. doi:10.21294/1814-4861-2018-17-3-64-71

Сычева И.В. Лучевые повреждения органов малого таза у онкогинекологических больных и их лечение: свидетельство о регистрации базы данных RU 2020620609, 27.03.2020. Заявка № 2020620650 от 20.03.2020 г. // Программы ЭВМ. Базы данных. Топологии интегральных микросхем. М: ФИПС, 2020;4 [Sycheva I.V. Radiation injuries of the pelvic organs in oncogynecological patients and their treatment: certificate of registration of the database RU 2020620609, 27.03.2020. Application № 2020620650 of 20.03.2020. Computer programs. Databases. Topologies of integrated circuits. Moscow: FIPS, 2020;4 (In Russ.).].

Сычева И.В., Каприн А.Д., Пасов В.В., Иванов С.А. Лечение поздних лучевых повреждений после брахитерапии и сочетанной лучевой терапии рака предстательной железы // Вопросы урологии и андрологии. 2014;3(3):15–20 [Sycheva IV, Kaprin AD, Pasov VV, Ivanov SA. Treatment of delayed radiation lesions after brachytherapy and combined radiotherapy for prostate cancer // Voprosy urologii i andrologii. 2014;3(3):15–20 (In Russ.)].

Топчий Т.Б., Сычева И.В., Рухадзе Г.О. и др. Лучевые проктиты: пособие для врачей. М: Прима Принт, 2019 [Topchiy TB, Sycheva IV, Rukhadze GO et al. Radiation proctitis: a manual for doctors. M: Prima Print, 2019 (In Russ.)].

Boyko I, Pasov V, Sycheva IV, Kurpesheva A. Radiation injuries in patients with prostate cancer after interstitial radiation therapy with sealed I-125-sources and concurrent radiation therapy // Annals of Oncology. 2010;21(S8):303.

Fawaz ZS, Barkati M, Beauchemin MC et al. Cervical necrosis after chemoradiation for cervical cancer: case series and literature review // Radiat. Oncol. 2013;8:220. doi:10.1186/1748-717X-8-220

Kirchheiner K, Fidarova E, Nout R.A et al. Radiation-induced morphological changes in the vagina // Strahlenther. Onkol. 2012;188(11):1010–7. doi:10.1007/s00066-012-0222-0

Leiper K, Morris AI. Treatment of radiation proctitis // Clin. Oncol. (R. Coll. Radiol.). 2007;19(9):724–729.

Cotti G, Seid V, Araujo S et al. Conservative therapies for hemorrhagic radiation proctitis: a review // Rev. Hosp. Clin. Fac. Med. Sao Paulo. 2000;58(5):284–92. doi:10.1590/s0041-87812003000500008

Delishaj D, Barcellini A, D'Amico R et al. Vaginal toxicity after high-dose-rate endovaginal brachytherapy: 20 years of results // J. Contemp Brachytherapy. 2018;10(6):559–566. doi:10.5114/jcb.2018.79713

Payne H, Adamson A, Bahl A et al. Chemical-and radiation-induced haemorrhagic cystitis: current treatments and challenges // B.J.U. Int. 2013;112(7):885–97.

Zwaans BMM, Lamb LE, Bartolone S et al. Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies // Int. Urol. Nephrol. 2018;50(10):1745–1751. doi:10.1007/s11255-018-1970-2

Giannitsas K, Athanasopoulos A. Intravesical therapies for radiation cystitis // Curr. Urol. 2015;8(4):169–174. doi:10.1159/000365711

Mendenhall WM, Henderson JA, Hoppe BS et al. Hemorrhagic radiation cystitis // Am. J. Clin. Oncol. 2015;38(3):331–6. doi:10.1097/COC.0000000000000016

Hoffman KE, Horowitz NS, Russell AH. Healing of vulvo-vaginal radionecrosis following revascularization // Gynecol. Oncol. 2007;106(1):262–264.

Helissey C, Cavallero S, Brossard C et al. Chronic inflammation and radiation-induced cystitis: molecular background and therapeutic perspectives // Cells. 2020;24(10):21. doi:10.3390/cells10010021

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

David Zaridze, Andrey Kaprin, Ivan Stilidi, DYNAMICS OF MORBIDITY AND MORTALITY FROM MALIGNANT TUMORS IN RUSSIA , Voprosy onkologii : Vol. 64 No. 5 (2018)
Tatyana Semiglazova, Yevgeniya Tsyrlina, Artem Poltoratskiy, Yekaterina Busko, Vladislav Semiglazov, Anna Artemeva, Sergey Ivanov, Lev Bershteyn, Vladimir Anisimov, Aleksey Belyaev, Vladimir Semiglazov, V. Kostorov, Aleksey Novik, Boris Kasparov, Mikhail Osipov, Petr Krivorotko, Veronika Klimenko, Garik Dashyan, Ruslan Paltuev, Yelena Zhiltsova, Tengiz Tabagua, Aleksandr Komyakhov, Kirill Nikolaev, Viktoriya Bashlyk, Roman Donskikh, V. Apollonova, MELATONIN AND METFORMIN IN NEOADJUVANT HORMONOTHERAPY IN LOCALLY ADVANCED BREAST CANCER , Voprosy onkologii : Vol. 64 No. 5 (2018)
Natalya Severskaya, Andrey Rodichev, Aleksey Ilin, Dmitriy Semin, Pavel Isaev, Oksana Timokhina, Irina Chebotareva, Sergey Ivanov, Andrey Kaprin, THYROID TYPE CARCINOMA ARISING IN STRUMA OVARII. SIX CLINICAL CASES AND REVIEW , Voprosy onkologii : Vol. 64 No. 6 (2018)
Aleksey Ilin, Dmitriy Semin, Pavel Isaev, Natalya Severskaya, Feliks Sevryukov, Vyacheslav Polkin, Sergey Vasilkov, Andrey Kaprin, Sergey Ivanov, PAPILLARY THYROID CARCINOMA IN CHILDREN AND ADOLESCENTS, RESULTS OF TREATMENT OF 215 PATIENTS: FACTORS PREDICTING DISTANT METASTASES AND RECURRENCE OF THE DISEASE , Voprosy onkologii : Vol. 64 No. 6 (2018)
Vladimir Baryshev, Feliks Sevryukov, V. Andreev, L. Kondrashova, V. Kapinus, Vyacheslav Polkin, V. Pankratov, E. Akki, K. Baryshev, Andrey Kaprin, Sergey Ivanov, MESENCHYMAL CHONDROSARCOMA OF THE HEAD AND NECK. AN OVERVIEW OF THE FEATURES, PROGNOSTIC FACTORS AND DIRECTIONS OF THE SEARCH FOR TREATMENT STRATEGIES. CLINICAL CASE , Voprosy onkologii : Vol. 66 No. 4 (2020)
Artem Bukharov, Vitalii Derzhavin, Andrey Kaprin, Natalya Kharchenko, Gadzhimurad Zapirov, jun wang, Progress of research mechanisms for metastasis of a malignant tumor in the bone , Voprosy onkologii : Vol. 68 No. 4 (2022)
Pavel Rumyantsev, Petr Nikiforovich, Andrey Poloznikov, Andrey Abrosimov, Vladimir Saenko, T. Rogunovich, A. Budzin, Andrey Polyakov, Andrey Kaprin, Ivan Dedov, BRAFV600E MUTATION IN PAPILLARY THYROID CARCINOMA. CLINICAL AND METHODOLOGICAL ASPECTS , Voprosy onkologii : Vol. 65 No. 1 (2019)
Анна Чайка, Sergeevna, Vladimir Khomyakov, Andrey Ryabov, Andrey Kaprin, Therapy for HER2-positive gastric cancer: an overview of the molecular and genetic characteristics of the signaling pathway, the results of clinical trials. , Voprosy onkologii : Vol. 69 No. 1 (2023)
Vladimir Solodkiy, Andrey Kaprin, Sergey Ivanov, Dmitriy Fomin, Vladimir Bozhenko, Feliks Sevryukov, Valeriy Krylov, Yekaterina Dzhikiya, Yu. Blanter, Timur Izmaylov, O. Avilov, POSSIBILITIES OF PREOPERATIVE DIAGNOSIS OF IODINE RESISTANCE REGIONAL LYMPH NODES METASTASES OF DIFFERENTIATED THYROID CANCER , Voprosy onkologii : Vol. 65 No. 1 (2019)
Elena Rasskazova, Aziz Zikiryakhodzhaev, Andrey Kaprin, Recurrences and edges of R1 resection depending on histological characteristics and molecular biological types of breast cancer , Voprosy onkologii : Vol. 68 No. 3 (2022)

1 2 3 > >>