MOLECULAR DIAGNOSTICS OF BILATERAL BREAST CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-3-435-439

Published 01.03.2017

Svetlana Bekhtereva⁺⁻
Yevgeniy Imyanitov⁺⁻
Andrey Vazhenin⁺⁻
Alla Domozhirova⁺⁻
Sergey Yaytsev⁺⁻

Svetlana Bekhtereva

Chelyabinsk Regional Clinical Oncology Center, South Ural State Medical University

Yevgeniy Imyanitov

N.N. Petrov Research Institute of Oncology, I.I. Mechnikov North-West State Medical University

Andrey Vazhenin

Chelyabinsk Regional Clinical Oncology Center, South Ural State Medical University

Alla Domozhirova

Chelyabinsk Regional Clinical Oncology Center, South Ural State Medical University

Sergey Yaytsev

Chelyabinsk Regional Clinical Oncology Center, South Ural State Medical University

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Keywords

PRIMARY-MULTIPLE MALIGNANT TUMORS
BILATERAL BREAST CANCER
GENETIC STUDIES
RECESSIVE
PREVENTION

How to Cite

Bekhtereva, S., Imyanitov, Y., Vazhenin, A., Domozhirova, A., & Yaytsev, S. (2017). MOLECULAR DIAGNOSTICS OF BILATERAL BREAST CANCER. Voprosy Onkologii, 63(3), 435–439. https://doi.org/10.37469/0507-3758-2017-63-3-435-439

Abstract

The problem of primary multiplicity of malignant tumors remains actual in oncology due to growing number of patients with polyneoplasia especially of the breast. Modern genetic studies use “genetically enriched” cases of cancer, which include in particular primary-multiple malignant tumors of the breast. Practically every tumor has an individual set of somatic mutations and genetic mechanisms of breast cancer appearance are very different. The multicentre study shows the role of recessive determinants of the predisposition to bilateral breast cancer without a family history. The obtained data could be used in clinical practice as a secondary prevention of breast cancer.

https://doi.org/10.37469/0507-3758-2017-63-3-435-439

##article.numberofdownloads## 51

##article.numberofviews## 387

PDF (Русский)

References

Акуленко Л.В. О наследственном раке органов репродуктивной системы: клинические лекции. - Москва. - 2012. - 134 с.

Важенин А.В., Бехтерева Е.И., Бехтерева С.А., Полов Х.Я. Очерки первичной множественности злокачественных опухолей. - Челябинск, 2000. - 215 с.

Важенин А.В., Токов Ю.А., Пшиченко С.В. Заболеваемость и смертность от злокачественных новообразований, организация онкологической помощи населению Челябинской области в 2014 году.

Казубская Т.П. Клинико-генетический анализ первично-множественных злокачественных новообразований // Высокие технологии в онкологии: материалы UI Всероссийского съезда онкологов. Том 2. - Москва, 2005. - С. 327-328.

Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2014 г.- Москва. - 2015 г. - 236 с.

Летягин В.П., Лактионов К.П., Высоцкая И.В., Котов B.А. Рак молочной железы. - Москва, 1996.

Паяниди Ю.Г., Сельчук В.Ю. и др. Первично-множе-ственые злокачественные новообразования половых органов у женщин: пути профилактики // Опухоли женской репродуктивной системы. - 2010. - № 1. - C. 51-54.

Сорокин В.М. Риск возникновения множественных злокачественных опухолей у больных раком молочной железы // Онкология. - 2000. - Т.2. - № 3. - С. 157-161.

Чиссов В.И., Трахтенберг А.Х. Первично-множественные злокачественные опухоли: руководство для врачей. - Москва: Медицина, 2000 - 336 с.

Bilateral breast cancer: (Pap). 6 Congr.Eur.Soc.Surg. Oncol/ Helsinki,June 10-13,1992/Veloso V,Maria N,Gomes D. et al// Eur.J.Surg.Oncol./1992; 11(Suppl.): 27.

СНЕК2 Breast Cancer Case-Control Consortium. CHEK 2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10860 breast cancer cases and 9065 controls from 10 studies // Amer. J. Hum. Genet. - 2004. - Vol. 74. - P 1175-1182.

Grudinina N.A., Golubkov V.I., Tikhomirova O.S. et al. Prevalence of widespread BRCA1 gene mutations in patients with familial breast cancer from St. Petersburg// Russ. J. Genet. - 2005. - Vol. 41. - P 318-322.

Papp J., Raicevic L., Milasin J. Et. Al. Germline mutation analysis of BRCA 1 and BRCA2 genes in Yugoslav breast/ ovarian cancer families // Oncol.Rep. - 1999. - № 6. -P 1435-1438.

Tereschenko I.V., Basham V.M., Ponder B.A., Pharoah PD. BRCA1 and BRCA2 mutations in Russian familial breast cancer // Hum. Mutat. - 2002. - Vol.19. - P 184.

Zarate M.E. Carcinome primitive bilateral de mama // Rev.cubana med. - 1980. - Vol. 19. - № 2. - P 121129.

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