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Наследственные дефекты генов BRCA1 и BRCA2 - достоверный фактор риска развития ряда онкологических заболеваний как у женщин, так и у мужчин. В обзоре обобщены рекомендации Европейского общества медицинской онкологии (European Society for Medical Oncology, ESMO), Национальной онкологической сети США (National Comprehensive Cancer Network, NCCN) и других профессиональных сообществ в отношении показаний для проведения BRCA-тестирования, мер по ранней диагностике новообразований, а также профилактических мероприятий, направленных на уменьшение риска развития злокачественных опухолей у носителей патогенных аллелей BRCA1/2. Обсуждаются проблемы адаптации BRCA-диагностики к условиям нашей страны.Библиографические ссылки
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