Vol. 63 No. 4 (2017), ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

Vol. 63 No. 4 (2017)

EFFECT OF METFORMIN, MELATONIN AND THEIR COMBINATIONS WITH PACLITAXEL ON THE GROWTH OF TRANSPLANTABLE HER2-POSITIVE BREAST TUMOR IN FEMALE FVB/N MICE

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-4-650-654

Published 01.04.2017

Mikhail Osipov⁺⁻
Tatyana Semiglazova⁺⁻
Irina Popovich⁺⁻
Andrey Panchenko⁺⁻
Margarita Tyndyk⁺⁻
Mark Zabezhinskiy⁺⁻
Veronika Klimenko⁺⁻
Aleksandr Stukov⁺⁻
Vladimir Anisimov⁺⁻

Mikhail Osipov

N.N. Petrov Research Institute of Oncology

Tatyana Semiglazova

N.N. Petrov Research Institute of Oncology, I.I. Mechnikov North-West State Medical University

Irina Popovich

N.N. Petrov Research Institute of Oncology

Andrey Panchenko

N.N. Petrov Research Institute of Oncology

Margarita Tyndyk

N.N. Petrov Research Institute of Oncology

Mark Zabezhinskiy

N.N. Petrov Research Institute of Oncology

Veronika Klimenko

N.N. Petrov Research Institute of Oncology

Aleksandr Stukov

N.N. Petrov Research Institute of Oncology

Vladimir Anisimov

N.N. Petrov Research Institute of Oncology

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Keywords

METFORMIN
MELATONIN
PACLITAXEL
ПЕРЕВИВАЕМАЯ HER2-ПОЛОЖИТЕЛЬНАЯ ОПУХОЛЬ МОЛОЧНОЙ ЖЕЛЕЗЫ
INJECTED HER2-POSITIVE BREAST TUMOR
МЫШИ FBV/N
TUMOR GROWTH INDEX
FVB/N MICE

How to Cite

Osipov, M., Semiglazova, T., Popovich, I., Panchenko, A., Tyndyk, M., Zabezhinskiy, M., Klimenko, V., Stukov, A., & Anisimov, V. (2017). EFFECT OF METFORMIN, MELATONIN AND THEIR COMBINATIONS WITH PACLITAXEL ON THE GROWTH OF TRANSPLANTABLE HER2-POSITIVE BREAST TUMOR IN FEMALE FVB/N MICE. Voprosy Onkologii, 63(4), 650–654. https://doi.org/10.37469/0507-3758-2017-63-4-650-654

Abstract

69 female FVB/N mice were used. After subcutaneous inoculation of tumor cells of transplantable HER2-positive mammary adenocarcinoma all animals were randomly divided into 7 groups and received metformin 100 mg /kgdaily, melatonin 10 mg/kg daily, paclitaxel 6 mg/kg once a week as a monotherapy or in combination. Treatment efficacy was assessed by tumor growth inhibition and the tumor growth index. It was shown that melatonin increased the cytotoxic effect of pacli-taxel whereas monotherapy with metformin led to statistically significant tumor growth inhibition

https://doi.org/10.37469/0507-3758-2017-63-4-650-654

##article.numberofdownloads## 46

##article.numberofviews## 149

PDF (Русский)

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