Vol. 63 No. 5 (2017), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 63 No. 5 (2017)

THE PATH TO PERSONALIZED TREATMENT OF BREAST CANCER PATIENTS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-5-719-723

Published 01.05.2017

Oleg Kit⁺⁻
Yuliana Shatova⁺⁻
Yelena Frantsiyants⁺⁻
Inna Novikova⁺⁻
Yelena Zlatnik⁺⁻
Larisa Vashchenko⁺⁻
Lyubov Vladimirova⁺⁻
Yelena Dzhenkova⁺⁻
Nadezhda Nikolaeva⁺⁻

Oleg Kit

Rostov Research Institute of Oncology

Yuliana Shatova

Rostov Research Institute of Oncology

Yelena Frantsiyants

Rostov Research Institute of Oncology

Inna Novikova

Rostov Research Institute of Oncology

Yelena Zlatnik

Rostov Research Institute of Oncology

Larisa Vashchenko

Rostov Research Institute of Oncology

Lyubov Vladimirova

Rostov Research Institute of Oncology

Yelena Dzhenkova

Rostov Research Institute of Oncology

Nadezhda Nikolaeva

Rostov Research Institute of Oncology

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Keywords

BREAST CANCER
PERSONALIZED TREATMENT

How to Cite

Kit, O., Shatova, Y., Frantsiyants, Y., Novikova, I., Zlatnik, Y., Vashchenko, L., Vladimirova, L., Dzhenkova, Y., & Nikolaeva, N. (2017). THE PATH TO PERSONALIZED TREATMENT OF BREAST CANCER PATIENTS. Voprosy Onkologii, 63(5), 719–723. https://doi.org/10.37469/0507-3758-2017-63-5-719-723

Abstract

Risk factors, p53, bcl-2, Topo2α, E-cadgerin, androgen receptor's expression, estrodiol, estron, testosterone, progesterone, prolactin, estrogen methabolitis, sex-steroid connecting globulin, growth factors: VEGF, EGF, TGFß1, IGF1, IGF2, plasmin, plasminogen, u-PA, t-PA, PAI-1 levels in the tumor and perifocal tissue, population and subpopulation structure of the lymphocytes in peripheral blood, tumor and perifocal tissue, ploidy and cell cycle estimating among the 850 patients with different biologic breast cancer subtypes were tested. «Statistica 7.0» and MedCalc (version 9.3.5.0) were used for the statistical analysis. The results showed that it was impossible to analyze breast cancer only as a biological subtype according to the typical IGC. It was needed to use and other external and internal factors, determine biologic tumor behavior in complex with menstrual state of a woman. Only such way allowed developing the preventive services according tumor biological characteristics and patient's individual parameters and going to really personalized treatment and improving its results.

https://doi.org/10.37469/0507-3758-2017-63-5-719-723

##article.numberofdownloads## 34

##article.numberofviews## 124

PDF (Русский)

References

Безнос О.А., Буров Д.А., Сельчук В.Ю. и др. Взаимосвязь субпопуляций интратуморальных лимфоцитов с клиническими и патоморфологическими особенностями рака молочной железы//Опухоли женской репродуктивной системы. -2016. -Т. 12. -№ 2. -С. 13-17.

Берштейн Л.М. Эндокринология рака молочной железы как гетерогенного заболевания: десятилетие после миллениума//Вопросы онкологии. -2013. -Т. 59. -№ 3. -С. 292-298.

Кит О.И., Шатова Ю.С., Тодоров С.С. и др. Гетерогенность люминального рака молочной железы у женщин с различным репродуктивным статусом//Российский онкологический журнал. -2014. -Т. 9. -№ 6. -С. 14-17.

Кит О.И., Шатова Ю.С., Новикова И.А. и др. Экспрессия p53 и BCL2 при различных подтипах рака молочной железы//Фундаментальные исследования. -2014. -№. 10-1. -С. 85-88.

Новикова, И.А. Шатова Ю.С., Златник Е.Ю. и др. Пролиферативные и иммунологические характеристики молекулярно-биологических подтипов рака молочной железы//Международный журнал прикладных и фундаментальных исследований. -2014. -№. 11-1. -С. 116-119.

Семиглазов В.Ф. Стратегические и практические подходы к решению проблемы рака молочной железы//Вопросы онкологии. -2012. -Т. 58. -№ 2. -С. 148-152.

Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. -СПб.: Сотис, 1995. -221 с.

Шатова Ю.С., Ващенко Л.Н., Новикова И.А. и др. Экспрессия топоизомеразы-2а и Е-кадгерина при различных подтипах рака молочной железы и репродуктивном статусе больных//Современные проблемы науки и образования. -2015. -№ 3. -С. 156.

Шатова Ю.С., Франциянц Е.М., Новикова И.А. и др. Локальный гормональный фон опухоли и перифокаль-ной зоны у больных раком молочной железы: данные и перспективы их применения//опухоли женской репродуктивной системы. -2016. -Т. 12. -№ 3. -С. 30-35.

Chen C., Yuan J.P., Wei W. et al. Subtype classification for prediction of prognosis of breast cancer from a biomarker panel: correlations and indications//Int. J. Nanomedicine. -2014. -Vol. 9. -P. 1039-1048.

lorio M.V., Croce C.M. MicroRNAs in cancer: small molecules with a huge impact//J. Clin. Oncol. -2009. -Vol. 27. -P. 5848-5856.

Janni W.J., Rack B., Terstappen Leon W.M.M. et al. Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer//Clin. Cancer Res. -2016. -Vol. 22. -P. 2583-2593.

Pierga J., Petit T., Lévy C. et al. Pathological Response and Circulating Tumor Cell Count Identifies Treated HER2+Inflammatory Breast Cancer Patients with Excellent Prognosis: BEVERLY-2 Survival Data//Clin. Cancer Res. -2015. -Vol. 21. -P. 1298-1304.

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