Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

CLINICAL AND BIOLOGICAL MODEL FOR EVALUATION OF THE EFFECTIVENESS OF SYSTEMIC THERAPY FOR BREAST CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-289-297

Published 01.03.2018

Vladimir Semiglazov⁺⁻
Ye. Trufanova⁺⁻
Pavel Krzhivitskiy⁺⁻
Aleksey Belyaev⁺⁻
Aleksandra Kondakova⁺⁻
Sergey Yereshchenko⁺⁻
Yelena Zhiltsova⁺⁻
Andrey Mishchenko⁺⁻
Viktoriya Bashlyk⁺⁻
Asel Kudaybergenova⁺⁻
Veronika Klimenko⁺⁻
Anna Artemeva⁺⁻
Vladislav Semiglazov⁺⁻
Yekaterina Busko⁺⁻
Aleksandr Komyakhov⁺⁻
Tatyana Semiglazova⁺⁻
Garik Dashyan⁺⁻
Petr Krivorotko⁺⁻
A. Tseluyko⁺⁻

Vladimir Semiglazov

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

Ye. Trufanova

N.N. Petrov National Medical Research Center of Oncology

Pavel Krzhivitskiy

N.N. Petrov National Medical Research Center of Oncology

Aleksey Belyaev

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

Aleksandra Kondakova

N.N. Petrov National Medical Research Center of Oncology

Sergey Yereshchenko

N.N. Petrov National Medical Research Center of Oncology

Yelena Zhiltsova

N.N. Petrov National Medical Research Center of Oncology

Andrey Mishchenko

N.N. Petrov National Medical Research Center of Oncology

Viktoriya Bashlyk

N.N. Petrov National Medical Research Center of Oncology

Asel Kudaybergenova

N.N. Petrov National Medical Research Center of Oncology

Veronika Klimenko

N.N. Petrov National Medical Research Center of Oncology

Anna Artemeva

N.N. Petrov National Medical Research Center of Oncology

Vladislav Semiglazov

N.N. Petrov National Medical Research Center of Oncology

Yekaterina Busko

N.N. Petrov National Medical Research Center of Oncology

Aleksandr Komyakhov

N.N. Petrov National Medical Research Center of Oncology

Tatyana Semiglazova

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

Garik Dashyan

N.N. Petrov National Medical Research Center of Oncology

Petr Krivorotko

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

A. Tseluyko

N.N. Petrov National Medical Research Center of Oncology

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Keywords

BREAST CANCER
RADIOLOGICAL DIAGNOSTIC METHODS
BIOLOGICAL SUBTYPES
SYSTEMIC TREATMENT

How to Cite

Semiglazov, V., Trufanova, Y., Krzhivitskiy, P., Belyaev, A., Kondakova, A., Yereshchenko, S., Zhiltsova, Y., Mishchenko, A., Bashlyk, V., Kudaybergenova, A., Klimenko, V., Artemeva, A., Semiglazov, V., Busko, Y., Komyakhov, A., Semiglazova, T., Dashyan, G., Krivorotko, P., & Tseluyko, A. (2018). CLINICAL AND BIOLOGICAL MODEL FOR EVALUATION OF THE EFFECTIVENESS OF SYSTEMIC THERAPY FOR BREAST CANCER. Voprosy Onkologii, 64(3), 289–297. https://doi.org/10.37469/0507-3758-2018-64-3-289-297

Abstract

Purpose: To create a unified system of accelerated clinical trials of new drugs and regimens for breast cancer (BC).

Materials and methods: The study included 1214 patients with BC of different stages (cT1N1, cT2N1-2, cT2-3N0-2, cT2-3N0-1, cT4N0M0). According to trepan biopsy data and immunohistochemical examination (IHC) expression of ER, PR, HER2, and Ki67 was determined. The expression TUBBßIII, TOP2a, analyzes on the BRCA1/2 mutation was studied. The clinical response to neoadjuvant treatment was determined using the physical method, ultrasonography-elas-tography, mammography, contrast magnetic resonance imaging (MRI) and single-photon emission computer mammotography (SPECT-CT).

Results: The correlation index of complete responses (cCR) and total pathomorphological responses (pCR) according to MRI was 0.80, according to ultrasound - 0.61, mammography - 0.60, palpation - 0.57. The low level of amplification of the TUBßIII mRNA gene with a high level of amplification of the TOP2-a gene is a predictor of the achievement of pCR. The inclusion of a neoadjuvant treatment of triply-negative BC carboplatin in addition to paclitaxel or eribulin increases the frequency of reaching pCR (ypT0/is(yp)N0) from 20.3% to 47%.

https://doi.org/10.37469/0507-3758-2018-64-3-289-297

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