SIGNIFICANCE OF THE SLOWING DOWN OF THE RATE OF DECREASE OF TUMOR MARKERS IN CHILDREN WITH GERMINOGENIC TUMORS

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-378-383

Published 01.03.2018

Svetlana Kuleva⁺⁻
N. Faseeva⁺⁻

Svetlana Kuleva

N.N. Petrov National Medical Research Center of Oncology

N. Faseeva

N.N. Petrov National Medical Research Center of Oncology

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Keywords

CHILDREN
ALPHA-FETOPROTEIN
HALF-ELIMINATION PERIOD
PREDICTED TIME OF TUMOR MARKER NORMALIZATION
GERMOGENIC TUMOR

How to Cite

Kuleva, S., & Faseeva, N. (2018). SIGNIFICANCE OF THE SLOWING DOWN OF THE RATE OF DECREASE OF TUMOR MARKERS IN CHILDREN WITH GERMINOGENIC TUMORS. Voprosy Onkologii, 64(3), 378–383. https://doi.org/10.37469/0507-3758-2018-64-3-378-383

Abstract

The main tumor markers of germogenic tumors are alpha-fetoprotein (AFP) and ß-subunit of human chorionic gonadotropin. The speed of normalization of tumor markers in each patient is different and its slowing is often prognostically unfavorable factor for the outcome of the disease. Determination of the dynamics of the rate of decrease of AFP is the most important prognostic criterion for patients with secreting germicogenic tumors. The delayed elimination of AFP after the first weeks of polychemotherapy could be the basis for a transition to a more intensive curative program.

https://doi.org/10.37469/0507-3758-2018-64-3-378-383

PDF (Русский)

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