Vol. 64 No. 3 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 3 (2018)

ANALYSIS OF UNFAVORABLE PROGNOSTIC FACTORS IN PATIENTS WHO RECEIVED HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS STEM-CELL HEMOPOIETIC STEM CELLS TRANSPLANTATION FOR RELAPSES AND RESISTANT FORMS OF HODGKIN''S LYMPHOMA

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-414-418

Published 01.03.2018

Sergey Alekseev⁺⁻
A. Subora⁺⁻
P. Shilo⁺⁻
I. Ishmatova⁺⁻
Tatyana Semiglazova⁺⁻
Larisa Filatova⁺⁻
Svetlana Kuleva⁺⁻
Yuliya Oleynik⁺⁻
Yuliya Chudinovskikh⁺⁻
Yevgeniya Kharchenko⁺⁻
Margarita Motalkina⁺⁻
Ilya Zyuzgin⁺⁻
S. Shalaev⁺⁻

Sergey Alekseev

N.N. Petrov National Medical Research Center of Oncology

A. Subora

N.N. Petrov National Medical Research Center of Oncology

P. Shilo

N.N. Petrov National Medical Research Center of Oncology

I. Ishmatova

N.N. Petrov National Medical Research Center of Oncology

Tatyana Semiglazova

N.N. Petrov National Medical Research Center of Oncology, I.I. Mechnikov North-West State Medical University

Larisa Filatova

N.N. Petrov National Medical Research Center of Oncology

Svetlana Kuleva

N.N. Petrov National Medical Research Center of Oncology

Yuliya Oleynik

N.N. Petrov National Medical Research Center of Oncology

Yuliya Chudinovskikh

N.N. Petrov National Medical Research Center of Oncology

Yevgeniya Kharchenko

N.N. Petrov National Medical Research Center of Oncology

Margarita Motalkina

N.N. Petrov National Medical Research Center of Oncology

Ilya Zyuzgin

N.N. Petrov National Medical Research Center of Oncology

S. Shalaev

N.N. Petrov National Medical Research Center of Oncology

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Keywords

HODGKIN'S LYMPHOMA
HIGH DOSE CHEMOTHERAPY
AUTOLOGOUS STEM CELL TRANSPLANTATION

How to Cite

Alekseev, S., Subora, A., Shilo, P., Ishmatova, I., Semiglazova, T., Filatova, L., Kuleva, S., Oleynik, Y., Chudinovskikh, Y., Kharchenko, Y., Motalkina, M., Zyuzgin, I., & Shalaev, S. (2018). ANALYSIS OF UNFAVORABLE PROGNOSTIC FACTORS IN PATIENTS WHO RECEIVED HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS STEM-CELL HEMOPOIETIC STEM CELLS TRANSPLANTATION FOR RELAPSES AND RESISTANT FORMS OF HODGKIN’’S LYMPHOMA. Voprosy Onkologii, 64(3), 414–418. https://doi.org/10.37469/0507-3758-2018-64-3-414-418

Abstract

High dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) is suggested as the standard of treatment of patients with relapsed or refractory Hodgkin’s lymphoma (HL) providing long-term disease-free survival in over 50 % of patients. The insufficient number of Russian medical centers, which can provide HDCT with ASCT, result into a broken chain of treatment. The main goal of this thesis is the evaluation of a timely mannered qualified medical help as potential independent prognosis factor. Our study included data of patients with refractory or relapsed HL who underwent treatment between 2013 and 2017 in our Center. Due to our data the negative prognostic factors affecting progression-free survival are: primary refractory disease (60 % vs 94 %; HR 2,1 [95 % CI 1.20-3.56], p=0.041); response for the 1st line of salvage therapy less than complete remission (CR) (35 % vs 91 %; HR 2,4 [95 % CI 1.81-3.24], p=0.022), presence of chain treatment disruption (41 % vs 90 %; HR 2,9 [95 % CI 2.43-4.2], p=0.029), disease status less than CR prior ASCT (29 % vs 87 %; HR 4,3 [95 % CI 2.9-6.1], p=0.009). Our results demonstrate that timely mannered qualified medical care is a key component that improves the survival of patients with relapses and refractory forms of Hodgkin’s lymphoma.

https://doi.org/10.37469/0507-3758-2018-64-3-414-418

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References

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