EXPERIENCE OF THE APPLICATION OF THERMOCHEMIORRADIOTHERAPY IN COMBINED TREATMENT OF DYSTAL CANCER OF DIRECT INTESTINE
##article.numberofdownloads## 24
##article.numberofviews## 70
PDF (Русский)

Keywords

THERMOCHEMICAL RADIOTHERAPY
COMBINED TREATMENT
LOCAL HYPERTHERMIA
RADIATION THERAPY
RECTAL CANCER

How to Cite

Startseva, Z., Afanasev, S., & Plaskeeva, D. (2019). EXPERIENCE OF THE APPLICATION OF THERMOCHEMIORRADIOTHERAPY IN COMBINED TREATMENT OF DYSTAL CANCER OF DIRECT INTESTINE. Voprosy Onkologii, 65(1), 131–134. https://doi.org/10.37469/0507-3758-2019-65-1-131-134

Abstract

The article describes the experience of using ther-mochioradiotherapy in the combined treatment of distal locally advanced colorectal cancer, as well as comparing the effectiveness of treatment with chemoradiation therapy. The use of the proposed method as a component of the combined treatment of patients with rectal cancer allowed to increase the percentage of organ-preserving operations. As a result of thermochemotherapy, the prevalence of the primary tumor was significantly reduced, as a result of which the number of sphincter-bearing operations was reduced by almost 2 times (p <0.05). So the extirpation of the rectum was performed only by 16% (n = 4) of patients who received neoadjuvant thermoradiochemotherapy, a similar amount of surgical treatment was performed in 33% (n = 8) of cases in the chemoradiotherapy group. The results of treatment of patients with stages II distal rectal cancer of the II - IV stage allow the program to be regarded as an effective and safe method of treatment. This method will increase the percentage of organ-preserving operations, as a consequence, speed up the rehabilitation process and improve the standard of living of this category of patients.
https://doi.org/10.37469/0507-3758-2019-65-1-131-134
##article.numberofdownloads## 24
##article.numberofviews## 70
PDF (Русский)

References

Афанасьев С.Г., Старцева Ж.А., Тарасова А.С. и др. Результаты комбинированного лечения рака прямой кишки с применением пролонгированной предоперационной химиолучевой терапии // Сибирский онкологический журнал. 2012; 6: 5-12.

Афанасьев С.Г., Старцева Ж.А., Добродеев А.Ю., и др. Непосредственные результаты радикальных операций в условиях комбинированного лечения рака прямой кишки // Сибирский онкологический журнал. 2016; 15(1):5-10. DOI: 10.21294/1814-4861-2016-15-1-5-10

Барсуков Ю.А., Кузьмичев Д.В. Ткачев С.И. Алиев В.В. и др. Комплексное лечение больных раком прямой кишки с использованием неоадъювантной термохими-олучевой терапии // Онкологическая колопроктология 2014; (3):23-28. DOI: 10.17650/2220-3478-2014-0-3-23-28

Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2016 году изд. МНИОИ им. П.А. Герцена филиал ФГБУ «НМИРЦ» Минздрава России, Москва, 2017.

Расулов А.О., Гордеев С.С., Иванов В.А. и др. Короткий курс предоперационной лучевой терапии в комбинации с химиотерапией, локальной гипертермией и пролонгированным интервалом до операции в лечение рака прямой кишки: исследования II фазы // Онкологическая колопроктология 2016; 6(4): 24-30 DOI: 10.17650/2220-3478-2016-6-4-24-30

Стародубцева Д.А., Старцева Ж.А., Афанасьев С.Г, Добродеев А.Ю. Терморадиотерапия в комбинированном лечении рака прямой кишки (литературный обзор). Сибирский онкологический журнал. 2018; 17 (2):89-94. - DOI: 10.21294/1814-4861-2018-17-2-89-94

89-94. - DOI: 10.21294/1814-4861-2018-17-2-89-94

Ferlay J., Soerjomataram I., Ervik M., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2014.

Perez K, Safran H, Sikov W, Vrees M, Klipfel A, Shah N Complete Neoadjuvant Treatment for Rectal Cancer: The Brown University Oncology Group CONTRE Study // Am J Clin Oncol. 2017 Jun;40(3):283-287. DOI: 10.1097/C0C.0000000000000149

Shoji H., Motegi M., Osawa K. et al. A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study // Cancer Med 2015; 4 (6): 834-43. DOI: 10.1002/cam4.431

Schroeder C., Gani C., Lamprecht U., von Weyhern CH, Weinmann M., Bamberg M., Berger B. Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone // Int. J. Hyperthermia. 2012. Vol. 28 (8). P. 707-714. 10.3109 / DOI: 10.3109/02656736.2012.722263

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© АННМО «Вопросы онкологии», Copyright (c) 2019