ПРЕДВАРИТЕЛЬНЫЕ РЕЗУЛЬТАТЫ ПРИМЕНЕНИЯ ПРЕДОПЕРАЦИОННОЙ ХИМИОЛУЧЕВОЙ ТЕРАПИИ С КОНСОЛИДИРУЮЩЕЙ ХИМИОТЕРАПИЕЙ У ПАЦИЕНТОВ МЕСТНОРАСПРОСТРАНЕННЫМ РАКОМ ПРЯМОЙ КИШКИ
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Ключевые слова

МЕСТНО-РАСПРОСТРАНЕННЫЙ РАК ПРЯМОЙ КИШКИ
ХИМИОЛУЧЕВАЯ ТЕРАПИЯ
КОНСОЛИДИРУЮЩАЯ ХИМИОТЕРАПИЯ
ПОЛНЫЙ КЛИНИЧЕСКИЙ И МОРФОЛОГИЧЕСКИЙ ОТВЕТ ОПУХОЛИ

Аннотация

В статье рассматриваются предварительные результаты комплексного лечения больных местнораспространенным раком прямой кишки с предоперационной химиолучевой терапией (ХЛТ) и консолидирующей химиотерапией (ХТ). В исследование включено 89 больных со стадией опухолевого процесса T3(CRM+)-4N0-2M0. В группе А проводилась предоперационная ХЛТ в изодозе 56 Гр на фоне ХТ капецитабином 825 мг/м2 2 раза в сутки per os с консолидирующей ХТ (2 курса XELOX), в группе Б проводилось аналогичное лечение без консолидирующей ХТ. В группу А включено 49 пациентов, в группу Б - 40 пациентов. У 9 (18,4%) пациентов в группе А при контрольном обследовании диагностирован полный клинический ответ, что послужило причиной воздержания от хирургического лечения, и они взяты под динамическое наблюдение. У 9 из 40 (22,5%) прооперированных пациентов из группы А отмечен клинически значимый полный морфологический ответ в опухоли (ypT0N0). В контрольной группе Б полного клинического ответа не достигнуто ни у одного пациента...
https://doi.org/10.37469/0507-3758-2017-63-6-900-906
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Copyright (c) 2017 Арсен Расулов, Дмитрий Кузьмичев, Андрей Полыновский, Вячеслав Алиев, Сергей Ткачев, Николай Козлов, Z. Mamedly, Y. Suraeva