Vol. 66 No. 4 (2020), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 66 No. 4 (2020)

COMBINED DIAGNOSTICS OF LUNG CANCER USING EXHALED BREATH ANALSYSIS AND SPUTUM CYTOLOGY

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2020-66-4-381-384

Published 01.04.2020

A. Arseniev⁺⁻
A. Nefedova⁺⁻
A. Ganeeva⁺⁻
A. Nefedov⁺⁻
S. Novikov⁺⁻
Anton Barchuk⁺⁻
S. Kanaev⁺⁻
I. Jahatspanian⁺⁻
A. Gubal⁺⁻
A. Kononov⁺⁻
S. Tarkov⁺⁻
N. Aristidov⁺⁻

A. Arseniev

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Nefedova

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Ganeeva

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Nefedov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Novikov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

Anton Barchuk

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Kanaev

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

I. Jahatspanian

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Gubal

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

A. Kononov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

S. Tarkov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

N. Aristidov

FSBI «N.N. Petrov NMRC of Oncology» of the Ministry of Healthcare of the Russia

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Keywords

SCREENING
LUNG CANCER
GAS ANALYZER
EXHALED BREATH
SPUTUM CYTOLOGY

How to Cite

Arseniev, A., Nefedova, A., Ganeeva, A., Nefedov, A., Novikov, S., Barchuk, A., Kanaev, S., Jahatspanian, I., Gubal, A., Kononov, A., Tarkov, S., & Aristidov, N. (2020). COMBINED DIAGNOSTICS OF LUNG CANCER USING EXHALED BREATH ANALSYSIS AND SPUTUM CYTOLOGY. Voprosy Onkologii, 66(4), 381–384. https://doi.org/10.37469/0507-3758-2020-66-4-381-384

Abstract

In this article we summarize our own experience of lung cancer diagnostics using exhaled breath analysis with a non-selective method using metal oxide chemoresistor gas sensors with cross-sensitivity combined with the sputum cytology. Volatile organic compounds of exhaled breath change the conductivity of the sensor, the resulting pulse is displayed as a peak on the graph, the area of which is used as test results. The combination of two diagnostic techniques in 204 participants demonstrated the possibility of non-invasively detecting the disease at an early stage. The sensitivity, specificity and accuracy of the breath analysis was 91.2%, 100% and 93.4%, respectively. The combination of the breath test and the sputum cytology compared to the breath test alone showed statistically significant (p = 0.03) increase in sensitivity to 96.8% (95% CI: 80.9% -99%) with acceptable decrease in specificity to 93.4% (95% CI: 88% -96%). The convenience of analysis and realtime measurements show some promise for the early detection.

https://doi.org/10.37469/0507-3758-2020-66-4-381-384

##article.numberofdownloads## 42

##article.numberofviews## 227

PDF (Русский)

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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